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The map label for this gene is relA [H]

Identifier: 238925277

GI number: 238925277

Start: 2812918

End: 2815278

Strand: Reverse

Name: relA [H]

Synonym: EUBREC_2931

Alternate gene names: 238925277

Gene position: 2815278-2812918 (Counterclockwise)

Preceding gene: 238925278

Following gene: 238925276

Centisome position: 81.61

GC content: 48.24

Gene sequence:

>2361_bases
GTGAGACTATTGGCAGATTACTCAACAGAAGAATTAGAAAAAATAGCGGACAAATTTCGCTCAGATACCAGCGGTATAAG
GGGAACAAAGGATTTTACGAGCCCGGAGGAGCTTTACGATGAGCTGAAAAAGGAAATCAAAAAGTACCATCCGTCGGATG
ATACGAGCCTTGTGGACAAAGCCTACAGGGTAGCTTATGATGCTCATAAGGGTCAGGCACGTAAGTCAGGAGAGCCTTAT
ATCATACATCCGCTTTGTGTTGCCATAATACTCGCCGAGCTCGAGCTGGATAAGGAAACAATTGCAGCAGGTCTGCTCCA
TGATGTGCTGGAGGACACTATCATGACCATGGATGAGATGCGTGCAGAATTTGGAGACGATGTCGCACATCTGGTGGATG
GTGTCACGAAGTTAAAGCACCTGCATCTGACAGACAGCACCAAGGATCCGAAGGATAAGAATGCGGACAGGCTTGAGATG
CAGGCTGAGAATCTGCGCAAGATGTTTCTCGCCATGGCAAAGGATATCAGGGTCATCCTCATAAAGCTGGCAGACAGACT
GCACAATATGCGTACACTCAAGTACCAGTCCAAGGAGGCACAGCAGCGTATCGCCAGAGAGACACAGGATATCTACTGCC
CTATCGCACAGCGACTTGGTATCAGCAAGATAAAGATAGAGCTCGAGGACCTTTGTATGAAGTACCTCTATCCGGATGCC
TACTACGATCTGGTAGAGAAAGTAGCCCTCAGAAAGACAGAACGTGACACCTACATCCAGGGCCTGGTAAACGATGTCAA
GAAGTATGTTTCGGATGCCGGCATCAAGGCTGAGATATACGGCAGGGCAAAGCATTTCTTCAGTATATATAAGAAGATGG
TCAATCAGGACAAGACTATAGACCAGATATATGATCTATTTGCCATCAGGATTCTGGTGGATACAATACCGGACTGCTAC
GCAGTGCTTGGTATCATACATGAGAAGTATAAGCCTATACCGGGTCGTTTCAAGGACTATATCGCCATGCCGAAGCAGAA
CATGTACCAGTCGCTTCACACGACACTCATAGGCCCGAGCGGACAGCCGTTTGAGATACAGATTCGTACCTACGAGATGC
ATCGTACTGCTGAGTACGGTATCGCAGCGCACTGGAAGTACAAGGAAACAAACAACGGCAATGCCACTACCACCACTGTC
ACAGAGGAGGAGAAGCTCAGCTGGCTGCGCCAGATACTCGAGTGGCAGCAGGATATGTCGGATAATAAGGAGTTTATGAC
TTTATTAAAGAGTGATTTAAATTTATTCTCCGACAATGTATTTGCATTCACTCCATCCGGCGATGTAAAGAACCTGCCAA
AGGGCTCCACACCTATAGACTTTGCCTACAGCATACATTCTGCGGTCGGCAACAAGATGGTCGGTGCCAAGGTAAACGGC
AAGCTGGTGCCGATAGACTATGTCATCAAAAACGGTGACCAGATAGAGATAATCACCTCACAGAACTCCAAGGGACCAAG
CCGTGACTGGCTCAAGGTCGTAAAGAGCACACAGGCTAAGAACAAGATCAACCAGTGGTTCAGAAGTGAGCTCAAGGAGG
AGAATATACAGCACGGCAAGGATCTGATAGCAGCCTATGCCAAGGCAAAGGGCATCAACTTTGCTGAGATAAACAAGCCT
GAGTATCAGGAGAAAATACGCCGCAAATACGGTTTCCACGACTGGAACTCATGCCTTGCAACCGTCGGCCACGGCGGACT
CAAGGAGAGCCAGATAGTCAACAGGATGTACGATGAGTACAAGAAGGATCATGTGGTGCCGGTGACAGATGCAGATGTGC
TTGGCAGCATCGCAGAAAAGCAGCAGGCGGCAGCAGGCACACAGCCCGAGCACAAGTCAAAGAGCGGTATTGTGGTACAC
GGACTCTATGACGTGGCTGTGCACTTCTCGAAGTGCTGCAATCCTGTTCCGGGAGATGAAATCGTGGGCTTTGTCACAAG
AGGCCGAGGCATCTCCATCCACAGGACAGACTGCGTGAATATCATCAATCTGTCCAAGATAGAAAAGGACAGGCTCATAG
AAGCAGAGTGGCAGGATACAGCCCTCATGGACAACGGTGCCGAGTATCAGGCAGACTTAAAGATATTCTGTCATGACAGG
CCGGGACTGCTCGTAGATATCACAAAGATATTTACCGAGAAGGAAATCAATATCAGTGGTATACAGTCCAAGACCAGCAA
GCAGGGTATCGCTACAATCGAGGTATTTTTTAATATCAAAGGCAGGGACCAGATAAAGGTTCTCGTGGAGAAGCTCAGAC
AGATAGAAAGTGTAATAGACGTAGAGAGGACCACCGGCTAA

Upstream 100 bases:

>100_bases
CATGTATGGCGGAGTAAAGATGGTTATCGGCTAACAACATAAGATTGCAATTTTTAAAGAAATAAAATATAATGGCTACT
AAAGATACACTACAATCGAG

Downstream 100 bases:

>100_bases
ATCCCGGTGGTTCTTGCGTGAAGCATAACATATAACAGACAAGGAGTACACTCATATGGTAAATATGAAGATAGACCACT
TCGTAGTGGGACCGGTGCAG

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MRLLADYSTEELEKIADKFRSDTSGIRGTKDFTSPEELYDELKKEIKKYHPSDDTSLVDKAYRVAYDAHKGQARKSGEPY
IIHPLCVAIILAELELDKETIAAGLLHDVLEDTIMTMDEMRAEFGDDVAHLVDGVTKLKHLHLTDSTKDPKDKNADRLEM
QAENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYQSKEAQQRIARETQDIYCPIAQRLGISKIKIELEDLCMKYLYPDA
YYDLVEKVALRKTERDTYIQGLVNDVKKYVSDAGIKAEIYGRAKHFFSIYKKMVNQDKTIDQIYDLFAIRILVDTIPDCY
AVLGIIHEKYKPIPGRFKDYIAMPKQNMYQSLHTTLIGPSGQPFEIQIRTYEMHRTAEYGIAAHWKYKETNNGNATTTTV
TEEEKLSWLRQILEWQQDMSDNKEFMTLLKSDLNLFSDNVFAFTPSGDVKNLPKGSTPIDFAYSIHSAVGNKMVGAKVNG
KLVPIDYVIKNGDQIEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFRSELKEENIQHGKDLIAAYAKAKGINFAEINKP
EYQEKIRRKYGFHDWNSCLATVGHGGLKESQIVNRMYDEYKKDHVVPVTDADVLGSIAEKQQAAAGTQPEHKSKSGIVVH
GLYDVAVHFSKCCNPVPGDEIVGFVTRGRGISIHRTDCVNIINLSKIEKDRLIEAEWQDTALMDNGAEYQADLKIFCHDR
PGLLVDITKIFTEKEINISGIQSKTSKQGIATIEVFFNIKGRDQIKVLVEKLRQIESVIDVERTTG

Sequences:

>Translated_786_residues
MRLLADYSTEELEKIADKFRSDTSGIRGTKDFTSPEELYDELKKEIKKYHPSDDTSLVDKAYRVAYDAHKGQARKSGEPY
IIHPLCVAIILAELELDKETIAAGLLHDVLEDTIMTMDEMRAEFGDDVAHLVDGVTKLKHLHLTDSTKDPKDKNADRLEM
QAENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYQSKEAQQRIARETQDIYCPIAQRLGISKIKIELEDLCMKYLYPDA
YYDLVEKVALRKTERDTYIQGLVNDVKKYVSDAGIKAEIYGRAKHFFSIYKKMVNQDKTIDQIYDLFAIRILVDTIPDCY
AVLGIIHEKYKPIPGRFKDYIAMPKQNMYQSLHTTLIGPSGQPFEIQIRTYEMHRTAEYGIAAHWKYKETNNGNATTTTV
TEEEKLSWLRQILEWQQDMSDNKEFMTLLKSDLNLFSDNVFAFTPSGDVKNLPKGSTPIDFAYSIHSAVGNKMVGAKVNG
KLVPIDYVIKNGDQIEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFRSELKEENIQHGKDLIAAYAKAKGINFAEINKP
EYQEKIRRKYGFHDWNSCLATVGHGGLKESQIVNRMYDEYKKDHVVPVTDADVLGSIAEKQQAAAGTQPEHKSKSGIVVH
GLYDVAVHFSKCCNPVPGDEIVGFVTRGRGISIHRTDCVNIINLSKIEKDRLIEAEWQDTALMDNGAEYQADLKIFCHDR
PGLLVDITKIFTEKEINISGIQSKTSKQGIATIEVFFNIKGRDQIKVLVEKLRQIESVIDVERTTG
>Mature_786_residues
MRLLADYSTEELEKIADKFRSDTSGIRGTKDFTSPEELYDELKKEIKKYHPSDDTSLVDKAYRVAYDAHKGQARKSGEPY
IIHPLCVAIILAELELDKETIAAGLLHDVLEDTIMTMDEMRAEFGDDVAHLVDGVTKLKHLHLTDSTKDPKDKNADRLEM
QAENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYQSKEAQQRIARETQDIYCPIAQRLGISKIKIELEDLCMKYLYPDA
YYDLVEKVALRKTERDTYIQGLVNDVKKYVSDAGIKAEIYGRAKHFFSIYKKMVNQDKTIDQIYDLFAIRILVDTIPDCY
AVLGIIHEKYKPIPGRFKDYIAMPKQNMYQSLHTTLIGPSGQPFEIQIRTYEMHRTAEYGIAAHWKYKETNNGNATTTTV
TEEEKLSWLRQILEWQQDMSDNKEFMTLLKSDLNLFSDNVFAFTPSGDVKNLPKGSTPIDFAYSIHSAVGNKMVGAKVNG
KLVPIDYVIKNGDQIEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFRSELKEENIQHGKDLIAAYAKAKGINFAEINKP
EYQEKIRRKYGFHDWNSCLATVGHGGLKESQIVNRMYDEYKKDHVVPVTDADVLGSIAEKQQAAAGTQPEHKSKSGIVVH
GLYDVAVHFSKCCNPVPGDEIVGFVTRGRGISIHRTDCVNIINLSKIEKDRLIEAEWQDTALMDNGAEYQADLKIFCHDR
PGLLVDITKIFTEKEINISGIQSKTSKQGIATIEVFFNIKGRDQIKVLVEKLRQIESVIDVERTTG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=708, Percent_Identity=37.5706214689266, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1790082, Length=749, Percent_Identity=38.3177570093458, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI25143118, Length=147, Percent_Identity=36.0544217687075, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 89554; Mature: 89554

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLADYSTEELEKIADKFRSDTSGIRGTKDFTSPEELYDELKKEIKKYHPSDDTSLVDK
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
AYRVAYDAHKGQARKSGEPYIIHPLCVAIILAELELDKETIAAGLLHDVLEDTIMTMDEM
HHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RAEFGDDVAHLVDGVTKLKHLHLTDSTKDPKDKNADRLEMQAENLRKMFLAMAKDIRVIL
HHHHCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKLADRLHNMRTLKYQSKEAQQRIARETQDIYCPIAQRLGISKIKIELEDLCMKYLYPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHCCHH
YYDLVEKVALRKTERDTYIQGLVNDVKKYVSDAGIKAEIYGRAKHFFSIYKKMVNQDKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHH
DQIYDLFAIRILVDTIPDCYAVLGIIHEKYKPIPGRFKDYIAMPKQNMYQSLHTTLIGPS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHEECCC
GQPFEIQIRTYEMHRTAEYGIAAHWKYKETNNGNATTTTVTEEEKLSWLRQILEWQQDMS
CCCEEEEEEEEEEHHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
DNKEFMTLLKSDLNLFSDNVFAFTPSGDVKNLPKGSTPIDFAYSIHSAVGNKMVGAKVNG
CCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECEECCC
KLVPIDYVIKNGDQIEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFRSELKEENIQHGK
EEEEEEHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIAAYAKAKGINFAEINKPEYQEKIRRKYGFHDWNSCLATVGHGGLKESQIVNRMYDEY
HHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
KKDHVVPVTDADVLGSIAEKQQAAAGTQPEHKSKSGIVVHGLYDVAVHFSKCCNPVPGDE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHH
IVGFVTRGRGISIHRTDCVNIINLSKIEKDRLIEAEWQDTALMDNGAEYQADLKIFCHDR
HEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEEEECC
PGLLVDITKIFTEKEINISGIQSKTSKQGIATIEVFFNIKGRDQIKVLVEKLRQIESVID
CCCEEEHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VERTTG
HHHCCC
>Mature Secondary Structure
MRLLADYSTEELEKIADKFRSDTSGIRGTKDFTSPEELYDELKKEIKKYHPSDDTSLVDK
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
AYRVAYDAHKGQARKSGEPYIIHPLCVAIILAELELDKETIAAGLLHDVLEDTIMTMDEM
HHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RAEFGDDVAHLVDGVTKLKHLHLTDSTKDPKDKNADRLEMQAENLRKMFLAMAKDIRVIL
HHHHCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKLADRLHNMRTLKYQSKEAQQRIARETQDIYCPIAQRLGISKIKIELEDLCMKYLYPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHCCHH
YYDLVEKVALRKTERDTYIQGLVNDVKKYVSDAGIKAEIYGRAKHFFSIYKKMVNQDKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHH
DQIYDLFAIRILVDTIPDCYAVLGIIHEKYKPIPGRFKDYIAMPKQNMYQSLHTTLIGPS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHEECCC
GQPFEIQIRTYEMHRTAEYGIAAHWKYKETNNGNATTTTVTEEEKLSWLRQILEWQQDMS
CCCEEEEEEEEEEHHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
DNKEFMTLLKSDLNLFSDNVFAFTPSGDVKNLPKGSTPIDFAYSIHSAVGNKMVGAKVNG
CCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECEECCC
KLVPIDYVIKNGDQIEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFRSELKEENIQHGK
EEEEEEHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIAAYAKAKGINFAEINKPEYQEKIRRKYGFHDWNSCLATVGHGGLKESQIVNRMYDEY
HHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
KKDHVVPVTDADVLGSIAEKQQAAAGTQPEHKSKSGIVVHGLYDVAVHFSKCCNPVPGDE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHH
IVGFVTRGRGISIHRTDCVNIINLSKIEKDRLIEAEWQDTALMDNGAEYQADLKIFCHDR
HEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEEEECC
PGLLVDITKIFTEKEINISGIQSKTSKQGIATIEVFFNIKGRDQIKVLVEKLRQIESVID
CCCEEEHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VERTTG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]