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The map label for this gene is lrgB [H]

Identifier: 238925238

GI number: 238925238

Start: 2769978

End: 2770670

Strand: Reverse

Name: lrgB [H]

Synonym: EUBREC_2892

Alternate gene names: 238925238

Gene position: 2770670-2769978 (Counterclockwise)

Preceding gene: 238925239

Following gene: 238925237

Centisome position: 80.32

GC content: 47.33

Gene sequence:

>693_bases
ATGGATAATTTGTTTCAGACATCGCTTTTTGCCGGTGTCACAGTAAGTCTGGTTGCATATCTGCTAGGTATGCTTTTAAA
GAAAAAGTTTAAGCTTGCAATACTCAATCCGCTTCTCATTTCAATAGTACTGACCATCATAGTGCTTGTTGTGGCAGATG
TGGATTATGACACATACAATAAGGGGGCATCGTACCTTAGCTGGTTTCTGACACCGGCCACGGTATGCCTTGCGATACCG
CTCTATGAGCAGTGGACACTGCTCAAGAAAAATATAGCAGCAGTCGCGCTCGGACTCACGGCAGGAGTCATAACAAGCCT
TGTGACAGTGCTTGTGCTGTCAGTGCTTATGGGGCTTTCACACGAGGACTATGTCACACTGCTTCCAAAGTCCATCACGA
CAGCTATCGGTATGGGTGTATCAGAGGAGCTCGGAGGATATGTGACCATCACTGTCGCAGTTATCGTCGTGACAGGTGTG
CTTGGAAATATACTCGGAGAGTTTGTTTGCAAAATATTCAGAATCACTGAGCCTATATCGAAGGGACTGGCGCTTGGTGC
GTCATCACATGCCATCGGAACAGCGAAGGCTATCGAGATTGGCGAGATAGAGGGCGCCATGAGCTCTCTTGCTATCGCGG
TGGCAGGAATACTTACGGTGGTGTTTGCATCGGTGTTTGCAAACTTTTATTGA

Upstream 100 bases:

>100_bases
TAATGATTGCTACAGGACATGTTTCACAGCTCGTAATCCGTATGCAGAAGCGCAAGAGGGCTGATGCTGGAGAAAATAAA
TAAGATAGAGGATAATCATA

Downstream 100 bases:

>100_bases
TTTGTCTGAGCGCTTCATGCGCGTTGGCTTTTTTACAGAAAGGAGCTATATTTATATGATAATTACAATTGCTAGAAAGT
GCGGTTGCGATGCAGATACT

Product: LrgB-like family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MDNLFQTSLFAGVTVSLVAYLLGMLLKKKFKLAILNPLLISIVLTIIVLVVADVDYDTYNKGASYLSWFLTPATVCLAIP
LYEQWTLLKKNIAAVALGLTAGVITSLVTVLVLSVLMGLSHEDYVTLLPKSITTAIGMGVSEELGGYVTITVAVIVVTGV
LGNILGEFVCKIFRITEPISKGLALGASSHAIGTAKAIEIGEIEGAMSSLAIAVAGILTVVFASVFANFY

Sequences:

>Translated_230_residues
MDNLFQTSLFAGVTVSLVAYLLGMLLKKKFKLAILNPLLISIVLTIIVLVVADVDYDTYNKGASYLSWFLTPATVCLAIP
LYEQWTLLKKNIAAVALGLTAGVITSLVTVLVLSVLMGLSHEDYVTLLPKSITTAIGMGVSEELGGYVTITVAVIVVTGV
LGNILGEFVCKIFRITEPISKGLALGASSHAIGTAKAIEIGEIEGAMSSLAIAVAGILTVVFASVFANFY
>Mature_230_residues
MDNLFQTSLFAGVTVSLVAYLLGMLLKKKFKLAILNPLLISIVLTIIVLVVADVDYDTYNKGASYLSWFLTPATVCLAIP
LYEQWTLLKKNIAAVALGLTAGVITSLVTVLVLSVLMGLSHEDYVTLLPKSITTAIGMGVSEELGGYVTITVAVIVVTGV
LGNILGEFVCKIFRITEPISKGLALGASSHAIGTAKAIEIGEIEGAMSSLAIAVAGILTVVFASVFANFY

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788464, Length=210, Percent_Identity=36.1904761904762, Blast_Score=139, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007300 [H]

Pfam domain/function: PF04172 LrgB [H]

EC number: NA

Molecular weight: Translated: 24217; Mature: 24217

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLFQTSLFAGVTVSLVAYLLGMLLKKKFKLAILNPLLISIVLTIIVLVVADVDYDTYN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
KGASYLSWFLTPATVCLAIPLYEQWTLLKKNIAAVALGLTAGVITSLVTVLVLSVLMGLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HEDYVTLLPKSITTAIGMGVSEELGGYVTITVAVIVVTGVLGNILGEFVCKIFRITEPIS
CCCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGLALGASSHAIGTAKAIEIGEIEGAMSSLAIAVAGILTVVFASVFANFY
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNLFQTSLFAGVTVSLVAYLLGMLLKKKFKLAILNPLLISIVLTIIVLVVADVDYDTYN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
KGASYLSWFLTPATVCLAIPLYEQWTLLKKNIAAVALGLTAGVITSLVTVLVLSVLMGLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HEDYVTLLPKSITTAIGMGVSEELGGYVTITVAVIVVTGVLGNILGEFVCKIFRITEPIS
CCCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGLALGASSHAIGTAKAIEIGEIEGAMSSLAIAVAGILTVVFASVFANFY
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA