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The map label for this gene is gltA [H]

Identifier: 238922352

GI number: 238922352

Start: 558655

End: 560028

Strand: Reverse

Name: gltA [H]

Synonym: EUBELI_20588

Alternate gene names: 238922352

Gene position: 560028-558655 (Counterclockwise)

Preceding gene: 238922353

Following gene: 238922351

Centisome position: 89.36

GC content: 36.32

Gene sequence:

>1374_bases
ATGAGTAGCAGGAAAGGGGTAATGGGAATGAACAATATGGATAATTACATGGAGCAGATGGCGGTTCTTTGTGAAAACAA
TGACAGTATCAACAAGAACCTGTATTCGGAGTATGGCGTAAAGCGTGGATTACGAGATGAAAATGGTCAGGGAGTATTGA
CAGGGCTTACTAATATATCTGACATAAAGGCTTTTGAATACCGTGATGGTAAAAAGTGTCCATGTGATGGAGAACTGTCA
TACAGAGGATACAATATAAGAGATTTTGTTGCAGGAAGCAAAGGGAAAAAGTATGTTTTTGAAGAAGGAGCATATCTGCT
TTTGTTTGGAGAACTTCCTGACAATGACCAGTTAAAGGAATTCCGTGATGAGTTATCAGAGTGTATGAAGCTGCCAACTA
ATTTTACAAGAGATGTTATAATGAAGGCTCCTACAGCGGATATAATGGGCTCAATGACCAGGAGTATTCTGACTCTTGGC
TCATATGATAAGAAAAAAGACAACTTAGATATACCTAATGTGTTAAGACAGAGTATGCAGCTTATTGCAACATTTCCGAT
GATTGCAGCATATGCATATCATGCTTATAATCATTACGAGAAGGATCAGAGCATGTATATTCACAGACCAGAAAAGGAAT
TATCTATAGCAGAGAATTTCCTGAGAATGCTTAGACCAGATACATGTTTTACAGATTTGGAAGCACGGGTTCTTGATATT
GCATTACTGCTGCATATGGAACATGGTGGTGGTAATAACTCTACATTTACTACAAGAGTTGTAACATCCTCTGGTTCTGA
TACATATTCTGTTATTGCCGCAGCTATGTCATCATTAAAAGGAAAGAAACATGGTGGCGCTAATCTTATGGTTATGAATA
TGATGGATGATATTAAGGAGCATGTTAAAGATTATGCAGATGAAGAAGAAATAGCTGCATATCTGGATAAATTGCTTAAC
AAGCAGGCATTTGACAAAAAAGGTCTTATATATGGTATGGGACATGCAGTATATTCTATCTCAGACCCAAGAGAGAAAGT
GTTTAAGGGATTCGTGGAGCAGCTTGCAACAGATAAGGGGCGCAATGAAGATATGCTTTTATATAATAATATTGAAAAAA
TTGCACCAAGGCTTATTGCAGAACAGAGAAAAATATATAAGGGAGTAAGTCCTAATATAGATTTCTATAGTGGATTTGTA
TATGATATGCTTGATATACCAAGAGAGTTATATACACCTTTATTTGCTATAGCCCGAATAGTTGGCTGGAGTGCACACAG
ACTGGAAGAATTAATAACTACAGATAAGATAATACGTCCTGCATATAAGAGTCTTGTAACTAAAAAAGAATATATTGACA
GAGAAAAAAGATAA

Upstream 100 bases:

>100_bases
AGCCGGTAAGTGATATTATTGCGGCTATTGTAACAACGATAGTATTTATGTTTAAGTTTAATAATATATTATCTGAAAAT
GAATAATATAAAAAATTTTA

Downstream 100 bases:

>100_bases
TTTTAACACCATATTCTGATTATAATGCAGGATATGGTGTATTTTTGTATATTTTGCTATAATAAAAAATGGGGAGGGAA
AACATATGATGAATAAAAAG

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSSRKGVMGMNNMDNYMEQMAVLCENNDSINKNLYSEYGVKRGLRDENGQGVLTGLTNISDIKAFEYRDGKKCPCDGELS
YRGYNIRDFVAGSKGKKYVFEEGAYLLLFGELPDNDQLKEFRDELSECMKLPTNFTRDVIMKAPTADIMGSMTRSILTLG
SYDKKKDNLDIPNVLRQSMQLIATFPMIAAYAYHAYNHYEKDQSMYIHRPEKELSIAENFLRMLRPDTCFTDLEARVLDI
ALLLHMEHGGGNNSTFTTRVVTSSGSDTYSVIAAAMSSLKGKKHGGANLMVMNMMDDIKEHVKDYADEEEIAAYLDKLLN
KQAFDKKGLIYGMGHAVYSISDPREKVFKGFVEQLATDKGRNEDMLLYNNIEKIAPRLIAEQRKIYKGVSPNIDFYSGFV
YDMLDIPRELYTPLFAIARIVGWSAHRLEELITTDKIIRPAYKSLVTKKEYIDREKR

Sequences:

>Translated_457_residues
MSSRKGVMGMNNMDNYMEQMAVLCENNDSINKNLYSEYGVKRGLRDENGQGVLTGLTNISDIKAFEYRDGKKCPCDGELS
YRGYNIRDFVAGSKGKKYVFEEGAYLLLFGELPDNDQLKEFRDELSECMKLPTNFTRDVIMKAPTADIMGSMTRSILTLG
SYDKKKDNLDIPNVLRQSMQLIATFPMIAAYAYHAYNHYEKDQSMYIHRPEKELSIAENFLRMLRPDTCFTDLEARVLDI
ALLLHMEHGGGNNSTFTTRVVTSSGSDTYSVIAAAMSSLKGKKHGGANLMVMNMMDDIKEHVKDYADEEEIAAYLDKLLN
KQAFDKKGLIYGMGHAVYSISDPREKVFKGFVEQLATDKGRNEDMLLYNNIEKIAPRLIAEQRKIYKGVSPNIDFYSGFV
YDMLDIPRELYTPLFAIARIVGWSAHRLEELITTDKIIRPAYKSLVTKKEYIDREKR
>Mature_456_residues
SSRKGVMGMNNMDNYMEQMAVLCENNDSINKNLYSEYGVKRGLRDENGQGVLTGLTNISDIKAFEYRDGKKCPCDGELSY
RGYNIRDFVAGSKGKKYVFEEGAYLLLFGELPDNDQLKEFRDELSECMKLPTNFTRDVIMKAPTADIMGSMTRSILTLGS
YDKKKDNLDIPNVLRQSMQLIATFPMIAAYAYHAYNHYEKDQSMYIHRPEKELSIAENFLRMLRPDTCFTDLEARVLDIA
LLLHMEHGGGNNSTFTTRVVTSSGSDTYSVIAAAMSSLKGKKHGGANLMVMNMMDDIKEHVKDYADEEEIAAYLDKLLNK
QAFDKKGLIYGMGHAVYSISDPREKVFKGFVEQLATDKGRNEDMLLYNNIEKIAPRLIAEQRKIYKGVSPNIDFYSGFVY
DMLDIPRELYTPLFAIARIVGWSAHRLEELITTDKIIRPAYKSLVTKKEYIDREKR

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=404, Percent_Identity=27.4752475247525, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786527, Length=366, Percent_Identity=33.6065573770492, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786939, Length=433, Percent_Identity=29.3302540415704, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17555174, Length=359, Percent_Identity=28.6908077994429, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=381, Percent_Identity=27.2965879265092, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=393, Percent_Identity=27.9898218829517, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=411, Percent_Identity=26.2773722627737, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640124, Length=368, Percent_Identity=29.0760869565217, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640126, Length=368, Percent_Identity=29.0760869565217, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21356863, Length=389, Percent_Identity=25.1928020565553, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 52130; Mature: 51999

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKGVMGMNNMDNYMEQMAVLCENNDSINKNLYSEYGVKRGLRDENGQGVLTGLTNIS
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHH
DIKAFEYRDGKKCPCDGELSYRGYNIRDFVAGSKGKKYVFEEGAYLLLFGELPDNDQLKE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCEEEEECCCCCCHHHHH
FRDELSECMKLPTNFTRDVIMKAPTADIMGSMTRSILTLGSYDKKKDNLDIPNVLRQSMQ
HHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LIATFPMIAAYAYHAYNHYEKDQSMYIHRPEKELSIAENFLRMLRPDTCFTDLEARVLDI
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALLLHMEHGGGNNSTFTTRVVTSSGSDTYSVIAAAMSSLKGKKHGGANLMVMNMMDDIKE
HHHHEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
HVKDYADEEEIAAYLDKLLNKQAFDKKGLIYGMGHAVYSISDPREKVFKGFVEQLATDKG
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHCCC
RNEDMLLYNNIEKIAPRLIAEQRKIYKGVSPNIDFYSGFVYDMLDIPRELYTPLFAIARI
CCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
VGWSAHRLEELITTDKIIRPAYKSLVTKKEYIDREKR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSRKGVMGMNNMDNYMEQMAVLCENNDSINKNLYSEYGVKRGLRDENGQGVLTGLTNIS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHH
DIKAFEYRDGKKCPCDGELSYRGYNIRDFVAGSKGKKYVFEEGAYLLLFGELPDNDQLKE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCEEEEECCCCCCHHHHH
FRDELSECMKLPTNFTRDVIMKAPTADIMGSMTRSILTLGSYDKKKDNLDIPNVLRQSMQ
HHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LIATFPMIAAYAYHAYNHYEKDQSMYIHRPEKELSIAENFLRMLRPDTCFTDLEARVLDI
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALLLHMEHGGGNNSTFTTRVVTSSGSDTYSVIAAAMSSLKGKKHGGANLMVMNMMDDIKE
HHHHEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
HVKDYADEEEIAAYLDKLLNKQAFDKKGLIYGMGHAVYSISDPREKVFKGFVEQLATDKG
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHCCC
RNEDMLLYNNIEKIAPRLIAEQRKIYKGVSPNIDFYSGFVYDMLDIPRELYTPLFAIARI
CCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
VGWSAHRLEELITTDKIIRPAYKSLVTKKEYIDREKR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]