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The map label for this gene is mepA [H]

Identifier: 238922314

GI number: 238922314

Start: 514004

End: 515329

Strand: Reverse

Name: mepA [H]

Synonym: EUBELI_20550

Alternate gene names: 238922314

Gene position: 515329-514004 (Counterclockwise)

Preceding gene: 238922315

Following gene: 238922313

Centisome position: 82.22

GC content: 39.22

Gene sequence:

>1326_bases
ATGAATCAGACATATATGAAGGAGCAGAAGATACTCCCATTGTTATTAAAAATGTCGCTTCCAATGGTAATATCAATGAT
GGTTAATTCATTGTACAACATTGTTGACAGCTTCTTTGTTGCCAAGATAAGTGAAAATGCGATGACAGCCTTGTCACTTG
TCTTTCCTGTACAGAATCTTATAAGCTCGGTTATGATAGGATTTGCAATAGGAATTAATGCGGTCATATCATTTTTTATG
GGTGCACAGAACCAGAAGCAGGCTGACAAGGCAGCTAGTCAGGGTATGCTCCTAAGCTGTATACACGCTGTTGTGCTTAC
AGTGATATGCATAGCAGGCATGCCGGTATTTTTAAAAATGTTTACAAAGGACGCAGAGATAGTTTCACTGGGACTTAAAT
ATTCCAATATTGCATTTGCATTTTCAATAATGCTTGGAATTGAGCTTATGTTTGAAAAGGTGTTTCAGGCAGTTGGAAGA
ATGAATGCTTCTATGGTCTGCCTTATGACAGGCTGTATAGTTAATATTGTGCTTGACCCGATGATGATATTCGGAATCGG
CCCATTTCCAGCAATGGGAATTGAGGGTGCTGCACTTGCGACAGGAATAGGTCAGACTTCGGCGGCTGTGCTCTATATAA
TAATATATATTGTTAAGCCTATTCCGGTTAAATTCAGAAAATCAGAGATGAGGATAGAAGGGTCAATGGCAAAGAGACTT
TATTCTATAGGCATGCCGGCAAGCTTAAGCCTTGCACTTCCATCTATTCTTATATCAGTGCTTAATGTAATACTTGCAGC
ATACTCTGCTGTGTATGTATTCGTGCTTGGCGTATATTACAAGCTGCAGACATTCCTTTATCTTCCAGCCAACGGAGTTG
TGCAGGGAATGAGACCACTTATGGGATATAATTACGGAGCAGGAGAGCATGAGAGAGTAAGAAAGATATATAAGACATCA
ATGGTACTTATATTTGCTATTATGGCAGCAGGTACAATTCTCTGTCTTGCAATACCGGGTTCACTTATCGGTCTGTTTAC
AAGTAATCCAGACACAATAAATGCAGGAGAGACAGCATTAAGAATCATAAGTGCCGGATTTATTGTATCAACTGTATCAG
TTACTTCGGCGGGGGCACTTGAAGGACTTGGAAAAGGATTTCCATCACTTATCATATCTGTGTGCAGATATGTTGCGGTA
ATAATTCCGGTTGCATTCGTTATGTCAAGGATAACAGGTGCAGTTGGTGTATGGCATGCTTTTTGGATTACCGAAGTGAT
TACATCAGTAATTTCTTATATAGTATATAAGAAAAATGTAAAGTAA

Upstream 100 bases:

>100_bases
TATGCGAAAGAATCTGGTTGAATAATTAAATATTATCGTGTATCATTAGAAAAAGAGCCACTTGTTGGCTCTTTTTTTAC
GAAAAGGACAGGTAGTTAAT

Downstream 100 bases:

>100_bases
TTATAAAAATGTCTTCTTGACATTGCTTGAACTTGGAAATACAATAGTTGCATATACAACAATTGGAGGTGCAAGTAATG
TTGAGAAGAATTTTTTCTTA

Product: multidrug resistance protein, MATE family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNQTYMKEQKILPLLLKMSLPMVISMMVNSLYNIVDSFFVAKISENAMTALSLVFPVQNLISSVMIGFAIGINAVISFFM
GAQNQKQADKAASQGMLLSCIHAVVLTVICIAGMPVFLKMFTKDAEIVSLGLKYSNIAFAFSIMLGIELMFEKVFQAVGR
MNASMVCLMTGCIVNIVLDPMMIFGIGPFPAMGIEGAALATGIGQTSAAVLYIIIYIVKPIPVKFRKSEMRIEGSMAKRL
YSIGMPASLSLALPSILISVLNVILAAYSAVYVFVLGVYYKLQTFLYLPANGVVQGMRPLMGYNYGAGEHERVRKIYKTS
MVLIFAIMAAGTILCLAIPGSLIGLFTSNPDTINAGETALRIISAGFIVSTVSVTSAGALEGLGKGFPSLIISVCRYVAV
IIPVAFVMSRITGAVGVWHAFWITEVITSVISYIVYKKNVK

Sequences:

>Translated_441_residues
MNQTYMKEQKILPLLLKMSLPMVISMMVNSLYNIVDSFFVAKISENAMTALSLVFPVQNLISSVMIGFAIGINAVISFFM
GAQNQKQADKAASQGMLLSCIHAVVLTVICIAGMPVFLKMFTKDAEIVSLGLKYSNIAFAFSIMLGIELMFEKVFQAVGR
MNASMVCLMTGCIVNIVLDPMMIFGIGPFPAMGIEGAALATGIGQTSAAVLYIIIYIVKPIPVKFRKSEMRIEGSMAKRL
YSIGMPASLSLALPSILISVLNVILAAYSAVYVFVLGVYYKLQTFLYLPANGVVQGMRPLMGYNYGAGEHERVRKIYKTS
MVLIFAIMAAGTILCLAIPGSLIGLFTSNPDTINAGETALRIISAGFIVSTVSVTSAGALEGLGKGFPSLIISVCRYVAV
IIPVAFVMSRITGAVGVWHAFWITEVITSVISYIVYKKNVK
>Mature_441_residues
MNQTYMKEQKILPLLLKMSLPMVISMMVNSLYNIVDSFFVAKISENAMTALSLVFPVQNLISSVMIGFAIGINAVISFFM
GAQNQKQADKAASQGMLLSCIHAVVLTVICIAGMPVFLKMFTKDAEIVSLGLKYSNIAFAFSIMLGIELMFEKVFQAVGR
MNASMVCLMTGCIVNIVLDPMMIFGIGPFPAMGIEGAALATGIGQTSAAVLYIIIYIVKPIPVKFRKSEMRIEGSMAKRL
YSIGMPASLSLALPSILISVLNVILAAYSAVYVFVLGVYYKLQTFLYLPANGVVQGMRPLMGYNYGAGEHERVRKIYKTS
MVLIFAIMAAGTILCLAIPGSLIGLFTSNPDTINAGETALRIISAGFIVSTVSVTSAGALEGLGKGFPSLIISVCRYVAV
IIPVAFVMSRITGAVGVWHAFWITEVITSVISYIVYKKNVK

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47583; Mature: 47583

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA