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The map label for this gene is envZ [H]

Identifier: 238921492

GI number: 238921492

Start: 3530275

End: 3531660

Strand: Reverse

Name: envZ [H]

Synonym: NT01EI_3644

Alternate gene names: 238921492

Gene position: 3531660-3530275 (Counterclockwise)

Preceding gene: 238921493

Following gene: 238921490

Centisome position: 92.64

GC content: 58.73

Gene sequence:

>1386_bases
ATGAGACGACTGCGTTTCTCGCCGCGCAGCTCTTTTGCCCGTACCCTGTTGCTGATCGTCACGCTACTGTTCGTCAGCCT
GGTGACGACCTACCTGGTCGTGTTGAACTTTGCCATTCTGCCCAGTTTGCAACAGTTCAATAAGGTGCTGGCCTATGAGG
TGCGGATGCTGATGACGGATAAGCTGCAGCTGGAGGATGGTACCCAGCTGGAGGTTCCGCCGGCGTTTCGCCGCGAGATT
TACCGCGAGCTTGGTATTTCGCTGTACACCAATTCAGCGGCGGAAGAGAATGGGCTGCGCTGGGCGCAACATTATCAGTT
TCTTAGCCAGCAGATGGCTCAGCAGCTGGGCGGTCCGACGGACGTGCGGGTTGAAATCAGCAAGAATACACCGGTGGTCT
GGCTCAAGACCTGGCTATCACCTGATATCTGGGTGCGGGTGCCGCTGACGGAGATCCATCAGGGCGATTTTTCACCGTTG
TTCCGCTACACGCTGGCGATTATGCTGCTGGCGATTGGCGGAGCCTGGCTGTTTATTCGGATACAAAATCGACCATTGGT
TGAGCTGGAGCATGCCGCCCTGCAGGTTGGCAAGGGGAAGATCCCGCCGCCGCTGCGTGAGTATGGCGCCTCGGAGGTGC
GCTCGGTGACCCGGGCGTTTAATCAGATGGCGGCGGGGGTTAAGCAGCTGGCCGACGATCGGACCCTGCTGATGGCCGGG
GTCAGCCACGATCTGCGTACCCCGCTAACGCGTATTCGTCTGGCGACAGAGATGATGAGTCCGCAGGATGCCTATCTGGC
GGAGTCGATCAATAAGGATACGGAAGAGTGTAACGCCATTATTGAGCAGTTTATCGACTATCTGCGCACCGGTCAGGAGA
TGCAGACTGAGGCGTGCGATCTGAACGGTATCCTGACCGAGGTCGTGGCGGCGGAGAGCGGCTATGAGCGTGAGATCGAT
ACCGATTTGGCCAACGGCGAGCTGTTGATCGATGCGCATCCGCTGTCGATTAAGCGGGCTGTCGTTAATATGGTGGTGAA
CGCGACCCGCTACGGTAATGGCTGGATCAAGGTCAGCAGCGGCATGGAGGGTGCGCGTGCCTGGTTCCAGGTGGAGGATG
ATGGCCCGGGGATCGACGATGCGCAGCTGGCCCATCTGTTCCAGCCCTTTGTCCGCGGTGAAAGCGCGAGAACCACCAGT
GGAACCGGTCTGGGGCTGGCGATCATTCAGCGTATTATCGATGCCCACCACGGCTCGCTGGATATTGGCCGCAGTGAGCG
CGGTGGACTGAAGATCCGTGCCTATTTACGACGGGTTAATGTCATCGTCTCCAATACACCCGATACCGCACCGCGCAGCG
GTGGGCGTCGCAAAGAGCGCGTCTGA

Upstream 100 bases:

>100_bases
CCCGTCTGCGTCGGATGGTAGAAGAGGACCCGGCGCATCCGCGCTACATTCAGACCGTATGGGGTCTGGGGTATGTCTTT
GTCCCGGACGGCAGTAAAGC

Downstream 100 bases:

>100_bases
AGCTCCGCCAGGCCAGAGAGCCGATGGTCAGTAAAAAGGATGCCCTTGGGCATCCTTTTTTACGTCAGGTGGCGTATATC
CGCGTGGGCGTGAGTTAGCG

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLEVPPAFRREI
YRELGISLYTNSAAEENGLRWAQHYQFLSQQMAQQLGGPTDVRVEISKNTPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGKIPPPLREYGASEVRSVTRAFNQMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSPQDAYLAESINKDTEECNAIIEQFIDYLRTGQEMQTEACDLNGILTEVVAAESGYEREID
TDLANGELLIDAHPLSIKRAVVNMVVNATRYGNGWIKVSSGMEGARAWFQVEDDGPGIDDAQLAHLFQPFVRGESARTTS
GTGLGLAIIQRIIDAHHGSLDIGRSERGGLKIRAYLRRVNVIVSNTPDTAPRSGGRRKERV

Sequences:

>Translated_461_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLEVPPAFRREI
YRELGISLYTNSAAEENGLRWAQHYQFLSQQMAQQLGGPTDVRVEISKNTPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGKIPPPLREYGASEVRSVTRAFNQMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSPQDAYLAESINKDTEECNAIIEQFIDYLRTGQEMQTEACDLNGILTEVVAAESGYEREID
TDLANGELLIDAHPLSIKRAVVNMVVNATRYGNGWIKVSSGMEGARAWFQVEDDGPGIDDAQLAHLFQPFVRGESARTTS
GTGLGLAIIQRIIDAHHGSLDIGRSERGGLKIRAYLRRVNVIVSNTPDTAPRSGGRRKERV
>Mature_461_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLEVPPAFRREI
YRELGISLYTNSAAEENGLRWAQHYQFLSQQMAQQLGGPTDVRVEISKNTPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGKIPPPLREYGASEVRSVTRAFNQMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSPQDAYLAESINKDTEECNAIIEQFIDYLRTGQEMQTEACDLNGILTEVVAAESGYEREID
TDLANGELLIDAHPLSIKRAVVNMVVNATRYGNGWIKVSSGMEGARAWFQVEDDGPGIDDAQLAHLFQPFVRGESARTTS
GTGLGLAIIQRIIDAHHGSLDIGRSERGGLKIRAYLRRVNVIVSNTPDTAPRSGGRRKERV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=436, Percent_Identity=86.4678899082569, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=31.294964028777, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=28.6792452830189, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=27.1739130434783, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=200, Percent_Identity=30.5, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=29.6610169491525, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=205, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=330, Percent_Identity=26.3636363636364, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790861, Length=267, Percent_Identity=25.4681647940075, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=279, Percent_Identity=23.6559139784946, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789403, Length=254, Percent_Identity=26.7716535433071, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51642; Mature: 51642

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KLQLEDGTQLEVPPAFRREIYRELGISLYTNSAAEENGLRWAQHYQFLSQQMAQQLGGPT
CEEECCCCEECCCHHHHHHHHHHHCCEEEECCCCHHCCCHHHHHHHHHHHHHHHHCCCCC
DVRVEISKNTPVVWLKTWLSPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGKIPPPLREYGASEVRSVTRAFNQMAAGVKQLADDRTLLMAG
ECCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSPQDAYLAESINKDTEECNAIIEQFIDYLRTGQEMQTEACD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHC
LNGILTEVVAAESGYEREIDTDLANGELLIDAHPLSIKRAVVNMVVNATRYGNGWIKVSS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEECCCEEEECC
GMEGARAWFQVEDDGPGIDDAQLAHLFQPFVRGESARTTSGTGLGLAIIQRIIDAHHGSL
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
DIGRSERGGLKIRAYLRRVNVIVSNTPDTAPRSGGRRKERV
ECCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KLQLEDGTQLEVPPAFRREIYRELGISLYTNSAAEENGLRWAQHYQFLSQQMAQQLGGPT
CEEECCCCEECCCHHHHHHHHHHHCCEEEECCCCHHCCCHHHHHHHHHHHHHHHHCCCCC
DVRVEISKNTPVVWLKTWLSPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGKIPPPLREYGASEVRSVTRAFNQMAAGVKQLADDRTLLMAG
ECCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSPQDAYLAESINKDTEECNAIIEQFIDYLRTGQEMQTEACD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHC
LNGILTEVVAAESGYEREIDTDLANGELLIDAHPLSIKRAVVNMVVNATRYGNGWIKVSS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEECCCEEEECC
GMEGARAWFQVEDDGPGIDDAQLAHLFQPFVRGESARTTSGTGLGLAIIQRIIDAHHGSL
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
DIGRSERGGLKIRAYLRRVNVIVSNTPDTAPRSGGRRKERV
ECCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]