| Definition | Edwardsiella ictaluri 93-146 chromosome, complete genome. |
|---|---|
| Accession | NC_012779 |
| Length | 3,812,315 |
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The map label for this gene is rotA [H]
Identifier: 238921461
GI number: 238921461
Start: 3498725
End: 3499291
Strand: Reverse
Name: rotA [H]
Synonym: NT01EI_3613
Alternate gene names: 238921461
Gene position: 3499291-3498725 (Counterclockwise)
Preceding gene: 238921463
Following gene: 238921459
Centisome position: 91.79
GC content: 55.56
Gene sequence:
>567_bases ATGTTCAAAAGAATCGTCATTACCCTGGTTACCCTCTTCTCGCTGGCCGTCATGGCCCCCGCCGCGCTGGCGGCCAACAC GCGGGTTATGCTGATGACCAGCGTAGGCAATATTGAGCTGGAGCTGTATAACCAGAAGGCGCCGGTAACCGTTGATAACT TTCTTGGCTACGTTAACAGCGGTTATTACAACGGCACCATTTTTCACCGCGTGATCCCGGGTTTTATGATTCAGGGCGGC GGTTTTACCGGCGATATGCAGCAGAAGGCGACGCAGCCGCCGATCAAGAACGAGGCGGACAACGGGCTGCGCAACCTGCG CGGTACTATTGCGATGGCGCGTACCGCAGAGAAAGACAGCGCGACCAGCCAGTTCTTTATCAACGTGGCGGACAACGCCT TTCTCGACCATGGACAGCGTGACTTTGGCTATGCTGTCTTTGGCAAAGTGATTAAGGGGATGGATGTCGTCGACAGGATC TCCCAGGCGCGTACCGAAAATGTCGGCCCTTACCAGAATGTGCCGGCCAAGCCGATCGTGATTACCTCGGCCAGCGTTAT GAAGTAA
Upstream 100 bases:
>100_bases AGTAAATGGGTGGCGATTATGCCAAGGGCTATTTAGAATCGTTAAGCTATTTTGTTGTTTTTACGCTTTTGACAAAGCCC GTCAGAGAAAGGAAGTTTTC
Downstream 100 bases:
>100_bases GGCTGTGCGCTTCTGCGCGGTTTCGCACAGCGGGCGCCGGATGGCGCCCGCTGTGTTACTGGCGCAGAAAGTTGCGCAGC AGGGCGTGTCCCTGCTCGCT
Product: peptidyl-prolyl cis-trans isomerase A (rotamase A)
Products: NA
Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]
Number of amino acids: Translated: 188; Mature: 188
Protein sequence:
>188_residues MFKRIVITLVTLFSLAVMAPAALAANTRVMLMTSVGNIELELYNQKAPVTVDNFLGYVNSGYYNGTIFHRVIPGFMIQGG GFTGDMQQKATQPPIKNEADNGLRNLRGTIAMARTAEKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVIKGMDVVDRI SQARTENVGPYQNVPAKPIVITSASVMK
Sequences:
>Translated_188_residues MFKRIVITLVTLFSLAVMAPAALAANTRVMLMTSVGNIELELYNQKAPVTVDNFLGYVNSGYYNGTIFHRVIPGFMIQGG GFTGDMQQKATQPPIKNEADNGLRNLRGTIAMARTAEKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVIKGMDVVDRI SQARTENVGPYQNVPAKPIVITSASVMK >Mature_188_residues MFKRIVITLVTLFSLAVMAPAALAANTRVMLMTSVGNIELELYNQKAPVTVDNFLGYVNSGYYNGTIFHRVIPGFMIQGG GFTGDMQQKATQPPIKNEADNGLRNLRGTIAMARTAEKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVIKGMDVVDRI SQARTENVGPYQNVPAKPIVITSASVMK
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Periplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI24308049, Length=177, Percent_Identity=36.7231638418079, Blast_Score=92, Evalue=3e-19, Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=36.0759493670886, Blast_Score=90, Evalue=1e-18, Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=34.7305389221557, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=38.3647798742138, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=33.9506172839506, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=33.9506172839506, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=33.9506172839506, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI4758950, Length=161, Percent_Identity=36.0248447204969, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.9712230215827, Blast_Score=71, Evalue=6e-13, Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=35.4609929078014, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=35.4609929078014, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI5454154, Length=165, Percent_Identity=32.7272727272727, Blast_Score=68, Evalue=4e-12, Organism=Homo sapiens, GI10863927, Length=160, Percent_Identity=33.125, Blast_Score=68, Evalue=4e-12, Organism=Escherichia coli, GI1789763, Length=189, Percent_Identity=73.015873015873, Blast_Score=290, Evalue=4e-80, Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=54.6583850931677, Blast_Score=177, Evalue=5e-46, Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=39.4366197183099, Blast_Score=93, Evalue=6e-20, Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=39.4366197183099, Blast_Score=93, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=33.5365853658537, Blast_Score=86, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17539496, Length=141, Percent_Identity=39.0070921985816, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17506311, Length=147, Percent_Identity=36.734693877551, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71997782, Length=126, Percent_Identity=36.5079365079365, Blast_Score=80, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17565860, Length=166, Percent_Identity=32.5301204819277, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17552782, Length=166, Percent_Identity=33.7349397590361, Blast_Score=75, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17552780, Length=189, Percent_Identity=35.4497354497354, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17551284, Length=199, Percent_Identity=30.6532663316583, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17551282, Length=199, Percent_Identity=30.6532663316583, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17566266, Length=166, Percent_Identity=31.3253012048193, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17559074, Length=166, Percent_Identity=31.9277108433735, Blast_Score=64, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6320510, Length=209, Percent_Identity=30.622009569378, Blast_Score=78, Evalue=9e-16, Organism=Saccharomyces cerevisiae, GI6323562, Length=199, Percent_Identity=34.6733668341709, Blast_Score=76, Evalue=3e-15, Organism=Saccharomyces cerevisiae, GI6321848, Length=148, Percent_Identity=35.8108108108108, Blast_Score=66, Evalue=3e-12, Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=38.6503067484663, Blast_Score=92, Evalue=2e-19, Organism=Drosophila melanogaster, GI19922912, Length=151, Percent_Identity=38.4105960264901, Blast_Score=82, Evalue=2e-16, Organism=Drosophila melanogaster, GI19922376, Length=161, Percent_Identity=31.6770186335404, Blast_Score=77, Evalue=5e-15, Organism=Drosophila melanogaster, GI21357249, Length=130, Percent_Identity=36.1538461538462, Blast_Score=74, Evalue=4e-14, Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=34.3065693430657, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI20130249, Length=158, Percent_Identity=36.7088607594937, Blast_Score=73, Evalue=1e-13, Organism=Drosophila melanogaster, GI45549139, Length=161, Percent_Identity=32.9192546583851, Blast_Score=71, Evalue=4e-13, Organism=Drosophila melanogaster, GI17647301, Length=160, Percent_Identity=35, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI17136360, Length=192, Percent_Identity=29.6875, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24664125, Length=162, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-12, Organism=Drosophila melanogaster, GI21357783, Length=162, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 20500; Mature: 20500
Theoretical pI: Translated: 9.84; Mature: 9.84
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 4.8 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 4.8 %Met (Mature Protein) 4.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFKRIVITLVTLFSLAVMAPAALAANTRVMLMTSVGNIELELYNQKAPVTVDNFLGYVNS CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEEHHHHHHHHCC GYYNGTIFHRVIPGFMIQGGGFTGDMQQKATQPPIKNEADNGLRNLRGTIAMARTAEKDS CEECCEEHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC ATSQFFINVADNAFLDHGQRDFGYAVFGKVIKGMDVVDRISQARTENVGPYQNVPAKPIV CCCEEEEEECCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEE ITSASVMK EECHHHCC >Mature Secondary Structure MFKRIVITLVTLFSLAVMAPAALAANTRVMLMTSVGNIELELYNQKAPVTVDNFLGYVNS CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEEHHHHHHHHCC GYYNGTIFHRVIPGFMIQGGGFTGDMQQKATQPPIKNEADNGLRNLRGTIAMARTAEKDS CEECCEEHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC ATSQFFINVADNAFLDHGQRDFGYAVFGKVIKGMDVVDRISQARTENVGPYQNVPAKPIV CCCEEEEEECCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEE ITSASVMK EECHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9418240 [H]