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The map label for this gene is aaeB [H]

Identifier: 238921336

GI number: 238921336

Start: 3374188

End: 3376134

Strand: Reverse

Name: aaeB [H]

Synonym: NT01EI_3480

Alternate gene names: 238921336

Gene position: 3376134-3374188 (Counterclockwise)

Preceding gene: 238921337

Following gene: 238921335

Centisome position: 88.56

GC content: 63.94

Gene sequence:

>1947_bases
ATGCTGTATCCACGCGCGATCCGCCTGCGCTTTGCCTGCAAGCTGACGCTGGCAAGCGTTCTGTCGCTGCTGCTCGGGTT
CTATTTCGGTCTGCCGATGCCGCGCTGGTCAGCGCTGACCGCTGCCCTGGTGGCCGCTGCCCCGGCCTTTGCCGCTGGCG
GTGAGCCTTTTTCTGGCGCCATTCGCTACCGCGGCTGGCTGCGTATCATCGGCACGGTATTGGGTTCCCTGTGCGCCCTG
CTGCTGATGATGCTATTGATTCGCGCACCGCTACTGATGATCCTGCTGTGCTGCCTGTGGGCGGGTGTCTGCACTTGGCT
GTCGTCGCTGGTGCGTATGGAGAACTCCTATGCACTGGGGTTGTCCGGTTATACGGCGTTGATCATCGTCGTCTCCTGCC
TCGGCGAGCCGCAGTTTATCCTGCAGCTGGCTCTGGAGCGCTGTGGGGAGATCGTGCTGGGGATCGTCTGCGCGGTGCTG
GTAGATACGCTGCTGGCGCCGCGCTCGGTTAAGGGGGAGGTGGATCGCGTCGTCGGCGGCATGTTGCTCGGCCAGCTACG
CCTGCTACAGTGCTGTGTCGACGGTCGCGACGGTGATGCCATCGACCGGAGCTGGCACAGGTTGATTAGGGAGAGTCATA
CGCTGGAAGAGATGCGCGCCAGCCTGGCGCTGGAGTCGTCTCGCTGGCCGCGTGCCTGTCGTCGGCTAACGGCGCTGCAC
ACCCTATCGCTGACGCTGATCACCCGGGCATGTGAAATTTTTCTGACTCAGTGTCAGACCCCTATGGCGCTGCCTGCGCC
GTTTTTGGCCCTGATAGCTGCTCCGGTAGACACGCCTGAGGAGGCCTATCAACGCTTAAAGCAGCTGCGTCGCCTGCTGG
TGGCGCACGGGGAGCATCAGCTGCCGCCCGCGCTGATCGGCTGGATCGGTGGCGCCAGTCGGCTGCAACTGTTGGTCAAA
GGTGTGGCGAGCAATGTCCGTATCGGGCGGTATGAGGCGGCGACCCTCGCTCACGACACCGCACCGCGCCCGCTCTACTC
CGTCCAGGGGCACCATGCATTGATCAATGGCCTGCGCACCTGGCTGGCCACCTCGCTGGGCGCGCTGTTTTGGCTGTGGA
GCGGCTGGAGCGCGGGCAGCGGCTGTATGATCATGATCGCGGTAGTGACCTCGCTGGCGGTACGCACCCCCAATCCGCGG
ATGGCGGCGATTGACTTTTTGATGGGCTCGCTGGTGGCGCTGCCGGTCGGCGCACTGTACTACACGCTGATCCTTCCCGC
CACGCAACAAAGCCTGGTACTGTTGTGCCTGAGCCTGGGCGCGTTGACCTTTATCTGCGGGATGGCGGTACAAAAGCGCC
GTCTGGGATCGATGGGAACGCTGGCCTCGACCCTGAATATTCTGGCGCTCAGCAATCCGATGGGGTTTCCGATAGAGCGC
TTTGTCGACAGCGCTATCGGCCAGATGGTCGGTTGCCTGCTGGCGCTGGTGGTGCTGCTGGTGGTACACGATCGTTCGCG
CGCCCGCACCGGGCGGGCGTTGATGCGGCATCTGGCGTTTGGCGCAGTGGCGGCCCTGCGGAGAGAGGGGACGCGTGGAA
ACCTGCTGCCGGCCCTCTACCGCCAGCTGCTTTTGCTGCTGACGCTGTTTCCCGATGACATTGGGCGTTATCGCCTGGCG
CTGACGCTGATCGTCCTACAGCAGCGTTTGGCGCACTCGGCGCTGCCATGTGATGCCGGGCGGCTGCGTGCTATCGACGC
AGCGGCAACCCGGCTCTTGAGCGGGGGCGGTTCGGCACGGTGCAGCGGTGCTCTTTTGCAGTTGACGACGGAGCTGGGTG
ACTATGCCGATTGTCTGGCGCGGCAGGGTATCGCCAGCGCCGTGCTGCAGCCGTTGCATCAGCTTGCCGATGTGCTGTAT
CGATACCGCAGCGTGCTGCTGGATTAG

Upstream 100 bases:

>100_bases
GTAGTGATCGGCACCGGCGGTGAGGCGCAGGCCGCGCGCCCGGCGCCGTACCGGCGTCTGCTGCAACGTCTGCGTGAGTT
GGGCTGAGTCGGGGGCTAAT

Downstream 100 bases:

>100_bases
GTGCATCGCTAACCCGGTGGCGCTTGCATCGGTACGATGATTAACCAAACGGATGCTTTATTAATCAAGTAACCGTTTGC
GCTAAATCAATCACTGGGGA

Product: p-hydroxybenzoic acid efflux subunit AaeB

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MLYPRAIRLRFACKLTLASVLSLLLGFYFGLPMPRWSALTAALVAAAPAFAAGGEPFSGAIRYRGWLRIIGTVLGSLCAL
LLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENSYALGLSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIVCAVL
VDTLLAPRSVKGEVDRVVGGMLLGQLRLLQCCVDGRDGDAIDRSWHRLIRESHTLEEMRASLALESSRWPRACRRLTALH
TLSLTLITRACEIFLTQCQTPMALPAPFLALIAAPVDTPEEAYQRLKQLRRLLVAHGEHQLPPALIGWIGGASRLQLLVK
GVASNVRIGRYEAATLAHDTAPRPLYSVQGHHALINGLRTWLATSLGALFWLWSGWSAGSGCMIMIAVVTSLAVRTPNPR
MAAIDFLMGSLVALPVGALYYTLILPATQQSLVLLCLSLGALTFICGMAVQKRRLGSMGTLASTLNILALSNPMGFPIER
FVDSAIGQMVGCLLALVVLLVVHDRSRARTGRALMRHLAFGAVAALRREGTRGNLLPALYRQLLLLLTLFPDDIGRYRLA
LTLIVLQQRLAHSALPCDAGRLRAIDAAATRLLSGGGSARCSGALLQLTTELGDYADCLARQGIASAVLQPLHQLADVLY
RYRSVLLD

Sequences:

>Translated_648_residues
MLYPRAIRLRFACKLTLASVLSLLLGFYFGLPMPRWSALTAALVAAAPAFAAGGEPFSGAIRYRGWLRIIGTVLGSLCAL
LLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENSYALGLSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIVCAVL
VDTLLAPRSVKGEVDRVVGGMLLGQLRLLQCCVDGRDGDAIDRSWHRLIRESHTLEEMRASLALESSRWPRACRRLTALH
TLSLTLITRACEIFLTQCQTPMALPAPFLALIAAPVDTPEEAYQRLKQLRRLLVAHGEHQLPPALIGWIGGASRLQLLVK
GVASNVRIGRYEAATLAHDTAPRPLYSVQGHHALINGLRTWLATSLGALFWLWSGWSAGSGCMIMIAVVTSLAVRTPNPR
MAAIDFLMGSLVALPVGALYYTLILPATQQSLVLLCLSLGALTFICGMAVQKRRLGSMGTLASTLNILALSNPMGFPIER
FVDSAIGQMVGCLLALVVLLVVHDRSRARTGRALMRHLAFGAVAALRREGTRGNLLPALYRQLLLLLTLFPDDIGRYRLA
LTLIVLQQRLAHSALPCDAGRLRAIDAAATRLLSGGGSARCSGALLQLTTELGDYADCLARQGIASAVLQPLHQLADVLY
RYRSVLLD
>Mature_648_residues
MLYPRAIRLRFACKLTLASVLSLLLGFYFGLPMPRWSALTAALVAAAPAFAAGGEPFSGAIRYRGWLRIIGTVLGSLCAL
LLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENSYALGLSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIVCAVL
VDTLLAPRSVKGEVDRVVGGMLLGQLRLLQCCVDGRDGDAIDRSWHRLIRESHTLEEMRASLALESSRWPRACRRLTALH
TLSLTLITRACEIFLTQCQTPMALPAPFLALIAAPVDTPEEAYQRLKQLRRLLVAHGEHQLPPALIGWIGGASRLQLLVK
GVASNVRIGRYEAATLAHDTAPRPLYSVQGHHALINGLRTWLATSLGALFWLWSGWSAGSGCMIMIAVVTSLAVRTPNPR
MAAIDFLMGSLVALPVGALYYTLILPATQQSLVLLCLSLGALTFICGMAVQKRRLGSMGTLASTLNILALSNPMGFPIER
FVDSAIGQMVGCLLALVVLLVVHDRSRARTGRALMRHLAFGAVAALRREGTRGNLLPALYRQLLLLLTLFPDDIGRYRLA
LTLIVLQQRLAHSALPCDAGRLRAIDAAATRLLSGGGSARCSGALLQLTTELGDYADCLARQGIASAVLQPLHQLADVLY
RYRSVLLD

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=645, Percent_Identity=49.922480620155, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1787933, Length=542, Percent_Identity=23.6162361623616, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 70171; Mature: 70171

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPRAIRLRFACKLTLASVLSLLLGFYFGLPMPRWSALTAALVAAAPAFAAGGEPFSGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
IRYRGWLRIIGTVLGSLCALLLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENSYALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
LSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIVCAVLVDTLLAPRSVKGEVDRVVGG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MLLGQLRLLQCCVDGRDGDAIDRSWHRLIRESHTLEEMRASLALESSRWPRACRRLTALH
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TLSLTLITRACEIFLTQCQTPMALPAPFLALIAAPVDTPEEAYQRLKQLRRLLVAHGEHQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
LPPALIGWIGGASRLQLLVKGVASNVRIGRYEAATLAHDTAPRPLYSVQGHHALINGLRT
CCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHH
WLATSLGALFWLWSGWSAGSGCMIMIAVVTSLAVRTPNPRMAAIDFLMGSLVALPVGALY
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
YTLILPATQQSLVLLCLSLGALTFICGMAVQKRRLGSMGTLASTLNILALSNPMGFPIER
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHH
FVDSAIGQMVGCLLALVVLLVVHDRSRARTGRALMRHLAFGAVAALRREGTRGNLLPALY
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RQLLLLLTLFPDDIGRYRLALTLIVLQQRLAHSALPCDAGRLRAIDAAATRLLSGGGSAR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
CSGALLQLTTELGDYADCLARQGIASAVLQPLHQLADVLYRYRSVLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYPRAIRLRFACKLTLASVLSLLLGFYFGLPMPRWSALTAALVAAAPAFAAGGEPFSGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
IRYRGWLRIIGTVLGSLCALLLMMLLIRAPLLMILLCCLWAGVCTWLSSLVRMENSYALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
LSGYTALIIVVSCLGEPQFILQLALERCGEIVLGIVCAVLVDTLLAPRSVKGEVDRVVGG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MLLGQLRLLQCCVDGRDGDAIDRSWHRLIRESHTLEEMRASLALESSRWPRACRRLTALH
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TLSLTLITRACEIFLTQCQTPMALPAPFLALIAAPVDTPEEAYQRLKQLRRLLVAHGEHQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
LPPALIGWIGGASRLQLLVKGVASNVRIGRYEAATLAHDTAPRPLYSVQGHHALINGLRT
CCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHH
WLATSLGALFWLWSGWSAGSGCMIMIAVVTSLAVRTPNPRMAAIDFLMGSLVALPVGALY
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
YTLILPATQQSLVLLCLSLGALTFICGMAVQKRRLGSMGTLASTLNILALSNPMGFPIER
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHH
FVDSAIGQMVGCLLALVVLLVVHDRSRARTGRALMRHLAFGAVAALRREGTRGNLLPALY
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RQLLLLLTLFPDDIGRYRLALTLIVLQQRLAHSALPCDAGRLRAIDAAATRLLSGGGSAR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
CSGALLQLTTELGDYADCLARQGIASAVLQPLHQLADVLYRYRSVLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA