Click here to switch to the map view.

The map label for this gene is speA [H]

Identifier: 238921231

GI number: 238921231

Start: 3261754

End: 3263730

Strand: Reverse

Name: speA [H]

Synonym: NT01EI_3374

Alternate gene names: 238921231

Gene position: 3263730-3261754 (Counterclockwise)

Preceding gene: 238921232

Following gene: 238921230

Centisome position: 85.61

GC content: 62.01

Gene sequence:

>1977_bases
GTGTCTGATTTGATTGCACAGTACCCGCAGGACTCGGCAGACAGCTCCCCTTTGCGTTCCATGCAGGAGGTTGCGATGAA
CGATAGTAATGCCAGCAAGATGTTGAGCACCTACAACGTCGCCTACTGGGGTGGCAACTATTACGATGTGAATGAGCTGG
GCCACATCTCCGTGTGCCCGGATCCCGACGTGCCGCAGGCGCGGGTCGATCTGACGGCGCTGGCGCTGCAGATCCAGGCC
GATCGTCAGCAGCGCCTGCCGGCGCTGTTCTGCTTTCCACAGATCCTGCAGCATCGCCTGCGCTCGATCAACGCTGCTTT
CCAGTGTGCACGCGCTTCGTTCGGCTACCAGGGGGATTACTTCCTGGTGTATCCGATCAAGGTCAACCAGCAGCGACGGG
TGATCGAGTCGCTGGTCAATTCCGGCGAGCCGCTGGGGTTGGAGGCCGGCTCCAAGGCCGAGCTGATGGCGGTATTGGCG
CACGCCGGCATGACGCGTAGCGTGATCGTCTGCAATGGCTATAAGGATCGCGAATATATCCGGTTGGCGCTGATCGGTGA
AAAGCTGGGTCACAAGGTCTACCTGGTCATCGAGAAGCTGAGCGAGATAGACGTGGTGCTGGAGGAGGCCAAGCGCCTCG
ACGTGGTACCGCGTCTCGGTGTGCGGGCGCGTCTGGCTTCGCAGGGATCAGGTAAGTGGCAGTCCAGCGGCGGAGAAAAG
TCCAAGTTTGGTCTGGCGGCGGTGCAGGTCCTGCAGCTGGTGGAAACCCTGCGTCAGGCCGGGCATCTGGAGAGCCTGCA
GCTGTTGCATTTCCATCTGGGGTCGCAGATGGCCAACATTCGCGATATTGCCACCGGGGTGCGTGAGTCGGCGCGTTTCT
ACGTCGAACTGCATAAGCTGGGGGTCAATATTCAGTGCTTCGACGTCGGCGGCGGCCTGGGCGTCGACTATGAGGGGACC
CGCTCCCAGTCCGACTGTTCGGTTAACTACGGCCTGAATGAGTACGCCAACAATGTGATCTGGGGGATTGGTGACGCCTG
TAATGAGCACGGTCTGCCACACCCGACGGTGATCACCGAGTCGGGCAGGGCGGTGACGGCGCACCATACGGTGCTGGTCT
CCAATATCATCGGGGTGGAGCGCAACGAACTGCCGCAGCCACAGCCGCCGGCCACCGATGCGCCGCGCGCGCTGCAGAGC
CTGTGGGCCACCTGGGAGGAGATGCAGGTGCCTGGCGGCCGCCGTTCGCTGCGCGAGTGGCTGCATGATAGCCAGCTCGA
TCTGCACGACGTGCACAGCCAGTATGCCCACGGGATCCTCAGCCTGAGCCAGCGCGCCTGGGCCGAACAGCAGTATCTGG
CCATCTGCAGCCAGCTACAGACCCAGCTGGATCCCAGCAACCGCGCCCATCGTCCGATCATCGATGAGCTGCAGGAGCGG
ATGGCCGATAAGCTGTACGTGAACTTCTCCCTGTTCCAGTCGATGCCAGACGCCTGGGGGATCGATCAGCTGTTCCCGGT
GCTGCCCCTCAGCGGGCTGGATAAGGTGCCGACGCGCCGCGCCGTGCTGCTGGATATCACCTGCGATTCGGATGGCACCA
TCGATCACTACATTGACGGCGACGGCGTGGCGACCACCATGCCGATGCCGGAGTACGATCCGCAGGATCCGCCGCTGGTG
GGCTTCTTCATGATCGGCGCCTACCAGGAGATCCTGGGCAACATGCATAACCTGTTCGGCGACACCGCCACGGTCGATGT
ATATGTGTTCGAGGACGGCAGCGTCGAGGTGGATGAATCCTACGACGGCAACTCCGTGGCGGAGATGCTGGAGTATGTAC
AGCTCGACCCGCAGGTGTTGCTGACCCACTTCCGCGATCAGGTGCGCGCGGCTCATCTGGACGGTGCGCTGCAGGCACAG
TTCCTGGAGGAGTTTGAGGCCGGTCTGTACGGCTACACCTACCTGGAAGACGAGTGA

Upstream 100 bases:

>100_bases
GTGGTCACGCCAAAAATCCCGGCGTGTGGGTTGCTCTATGCAGATGATGCTGCAATATTGGCTGGCGCGACGGTTGTCCT
CGCCGGAAAAGGAGCTGCCC

Downstream 100 bases:

>100_bases
TCGGCGCCCGGCGGCGCGTCGCCGCCGGGGAGATCCTCCGGGCTTGCAGTTGCGGTGGGTTGTCGCCATAATCGGCGAAA
TGCACTGCCAAACGAACTGA

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSDLIAQYPQDSADSSPLRSMQEVAMNDSNASKMLSTYNVAYWGGNYYDVNELGHISVCPDPDVPQARVDLTALALQIQA
DRQQRLPALFCFPQILQHRLRSINAAFQCARASFGYQGDYFLVYPIKVNQQRRVIESLVNSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKLSEIDVVLEEAKRLDVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAAVQVLQLVETLRQAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNIIGVERNELPQPQPPATDAPRALQS
LWATWEEMQVPGGRRSLREWLHDSQLDLHDVHSQYAHGILSLSQRAWAEQQYLAICSQLQTQLDPSNRAHRPIIDELQER
MADKLYVNFSLFQSMPDAWGIDQLFPVLPLSGLDKVPTRRAVLLDITCDSDGTIDHYIDGDGVATTMPMPEYDPQDPPLV
GFFMIGAYQEILGNMHNLFGDTATVDVYVFEDGSVEVDESYDGNSVAEMLEYVQLDPQVLLTHFRDQVRAAHLDGALQAQ
FLEEFEAGLYGYTYLEDE

Sequences:

>Translated_658_residues
MSDLIAQYPQDSADSSPLRSMQEVAMNDSNASKMLSTYNVAYWGGNYYDVNELGHISVCPDPDVPQARVDLTALALQIQA
DRQQRLPALFCFPQILQHRLRSINAAFQCARASFGYQGDYFLVYPIKVNQQRRVIESLVNSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKLSEIDVVLEEAKRLDVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAAVQVLQLVETLRQAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNIIGVERNELPQPQPPATDAPRALQS
LWATWEEMQVPGGRRSLREWLHDSQLDLHDVHSQYAHGILSLSQRAWAEQQYLAICSQLQTQLDPSNRAHRPIIDELQER
MADKLYVNFSLFQSMPDAWGIDQLFPVLPLSGLDKVPTRRAVLLDITCDSDGTIDHYIDGDGVATTMPMPEYDPQDPPLV
GFFMIGAYQEILGNMHNLFGDTATVDVYVFEDGSVEVDESYDGNSVAEMLEYVQLDPQVLLTHFRDQVRAAHLDGALQAQ
FLEEFEAGLYGYTYLEDE
>Mature_657_residues
SDLIAQYPQDSADSSPLRSMQEVAMNDSNASKMLSTYNVAYWGGNYYDVNELGHISVCPDPDVPQARVDLTALALQIQAD
RQQRLPALFCFPQILQHRLRSINAAFQCARASFGYQGDYFLVYPIKVNQQRRVIESLVNSGEPLGLEAGSKAELMAVLAH
AGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKLSEIDVVLEEAKRLDVVPRLGVRARLASQGSGKWQSSGGEKS
KFGLAAVQVLQLVETLRQAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGTR
SQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNIIGVERNELPQPQPPATDAPRALQSL
WATWEEMQVPGGRRSLREWLHDSQLDLHDVHSQYAHGILSLSQRAWAEQQYLAICSQLQTQLDPSNRAHRPIIDELQERM
ADKLYVNFSLFQSMPDAWGIDQLFPVLPLSGLDKVPTRRAVLLDITCDSDGTIDHYIDGDGVATTMPMPEYDPQDPPLVG
FFMIGAYQEILGNMHNLFGDTATVDVYVFEDGSVEVDESYDGNSVAEMLEYVQLDPQVLLTHFRDQVRAAHLDGALQAQF
LEEFEAGLYGYTYLEDE

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=656, Percent_Identity=82.0121951219512, Blast_Score=1135, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 73194; Mature: 73063

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLIAQYPQDSADSSPLRSMQEVAMNDSNASKMLSTYNVAYWGGNYYDVNELGHISVCP
CCCHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCEEECCCCCEEEECC
DPDVPQARVDLTALALQIQADRQQRLPALFCFPQILQHRLRSINAAFQCARASFGYQGDY
CCCCCCHHHHHHHHEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
FLVYPIKVNQQRRVIESLVNSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEE
RLALIGEKLGHKVYLVIEKLSEIDVVLEEAKRLDVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAAVQVLQLVETLRQAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCEEECCCCHHHCCCCCCCEEEEC
SGRAVTAHHTVLVSNIIGVERNELPQPQPPATDAPRALQSLWATWEEMQVPGGRRSLREW
CCCEEEHHHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LHDSQLDLHDVHSQYAHGILSLSQRAWAEQQYLAICSQLQTQLDPSNRAHRPIIDELQER
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKLYVNFSLFQSMPDAWGIDQLFPVLPLSGLDKVPTRRAVLLDITCDSDGTIDHYIDG
HHHHEEEEHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECC
DGVATTMPMPEYDPQDPPLVGFFMIGAYQEILGNMHNLFGDTATVDVYVFEDGSVEVDES
CCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCC
YDGNSVAEMLEYVQLDPQVLLTHFRDQVRAAHLDGALQAQFLEEFEAGLYGYTYLEDE
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SDLIAQYPQDSADSSPLRSMQEVAMNDSNASKMLSTYNVAYWGGNYYDVNELGHISVCP
CCHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCEEECCCCCEEEECC
DPDVPQARVDLTALALQIQADRQQRLPALFCFPQILQHRLRSINAAFQCARASFGYQGDY
CCCCCCHHHHHHHHEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
FLVYPIKVNQQRRVIESLVNSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEE
RLALIGEKLGHKVYLVIEKLSEIDVVLEEAKRLDVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAAVQVLQLVETLRQAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCEEECCCCHHHCCCCCCCEEEEC
SGRAVTAHHTVLVSNIIGVERNELPQPQPPATDAPRALQSLWATWEEMQVPGGRRSLREW
CCCEEEHHHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LHDSQLDLHDVHSQYAHGILSLSQRAWAEQQYLAICSQLQTQLDPSNRAHRPIIDELQER
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKLYVNFSLFQSMPDAWGIDQLFPVLPLSGLDKVPTRRAVLLDITCDSDGTIDHYIDG
HHHHEEEEHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECC
DGVATTMPMPEYDPQDPPLVGFFMIGAYQEILGNMHNLFGDTATVDVYVFEDGSVEVDES
CCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCC
YDGNSVAEMLEYVQLDPQVLLTHFRDQVRAAHLDGALQAQFLEEFEAGLYGYTYLEDE
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]