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The map label for this gene is ygfA [C]

Identifier: 238921217

GI number: 238921217

Start: 3246312

End: 3246938

Strand: Direct

Name: ygfA [C]

Synonym: NT01EI_3361

Alternate gene names: 238921217

Gene position: 3246312-3246938 (Clockwise)

Preceding gene: 238921216

Following gene: 238921220

Centisome position: 85.15

GC content: 63.96

Gene sequence:

>627_bases
ATGTCCCAGGAACCTGCGTTATCTTCCCGTCATCAGCTCCGTCATCGTCTGCGTACGCTGCGCCGTTCGCTTTCCCACAA
TCAGCAGTATCAGGCCGCCCTTGCGCTCAAAGATCATCTGCTGATGCTGCCACAGCTGAGCCAGCCGCGACATATCGCGC
TCTATTTACCCTTTGACGGCGAGCCGGATACCCAACCGCTGATCCACGCCCTGTGGCAACGCGGCCACCGGATCGCTCTG
CCGCGTTTGCATCCGTTCAGCTCCGGCCACCTGCTGTTTCTGGAATATACCCCGGATACTCCGATGTGCCACAACCGCTT
TGGTATCGCCGAGCCGTACCTGGACGTCACCCGGATTATTCCCCTGGCCCGGCTGGATCTGATCCTGACTCCGCTGGTGG
CCTTTGACCGGCAGGGACACCGGCTTGGCATGGGCGGTGGCTTTTACGATCGCACTCTGCAGGGGTGGCAGCAACGCCAC
CGCCTCGGCGTCGGCCCCTACCCCATCGGTCTGGCCCACGACTGTCAGCGCGTCGCAGCCCTGCCCGTTGCCGCCTGGGA
CGTGCCGCTGCCAGAGATCATCACCCCGCAGGCCCACTACCGCTGGCCAGACGCCGGCGCCGCTTAG

Upstream 100 bases:

>100_bases
GACGTTATGTTCACCTTGAACCCCGGGTTCAAGGGTTACAGCCTGTTACGGCACCTCGGAGATTCCCTAAAACGCCAGTC
CTGCTGTCAGAGTCACCTCC

Downstream 100 bases:

>100_bases
TACAGCAGACGGGCCCGCACGGTACCGGGGATCTCGCGCATGCGCTGTAGCGCAGCCTCCGCACGCTCGGTCTCCGTTTC
CACGTCGATCACCACATAGC

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSQEPALSSRHQLRHRLRTLRRSLSHNQQYQAALALKDHLLMLPQLSQPRHIALYLPFDGEPDTQPLIHALWQRGHRIAL
PRLHPFSSGHLLFLEYTPDTPMCHNRFGIAEPYLDVTRIIPLARLDLILTPLVAFDRQGHRLGMGGGFYDRTLQGWQQRH
RLGVGPYPIGLAHDCQRVAALPVAAWDVPLPEIITPQAHYRWPDAGAA

Sequences:

>Translated_208_residues
MSQEPALSSRHQLRHRLRTLRRSLSHNQQYQAALALKDHLLMLPQLSQPRHIALYLPFDGEPDTQPLIHALWQRGHRIAL
PRLHPFSSGHLLFLEYTPDTPMCHNRFGIAEPYLDVTRIIPLARLDLILTPLVAFDRQGHRLGMGGGFYDRTLQGWQQRH
RLGVGPYPIGLAHDCQRVAALPVAAWDVPLPEIITPQAHYRWPDAGAA
>Mature_207_residues
SQEPALSSRHQLRHRLRTLRRSLSHNQQYQAALALKDHLLMLPQLSQPRHIALYLPFDGEPDTQPLIHALWQRGHRIALP
RLHPFSSGHLLFLEYTPDTPMCHNRFGIAEPYLDVTRIIPLARLDLILTPLVAFDRQGHRLGMGGGFYDRTLQGWQQRHR
LGVGPYPIGLAHDCQRVAALPVAAWDVPLPEIITPQAHYRWPDAGAA

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=199, Percent_Identity=26.1306532663317, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1789278, Length=186, Percent_Identity=50, Blast_Score=194, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 23698; Mature: 23567

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEPALSSRHQLRHRLRTLRRSLSHNQQYQAALALKDHLLMLPQLSQPRHIALYLPFDG
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
EPDTQPLIHALWQRGHRIALPRLHPFSSGHLLFLEYTPDTPMCHNRFGIAEPYLDVTRII
CCCHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
PLARLDLILTPLVAFDRQGHRLGMGGGFYDRTLQGWQQRHRLGVGPYPIGLAHDCQRVAA
HHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LPVAAWDVPLPEIITPQAHYRWPDAGAA
CCHHCCCCCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQEPALSSRHQLRHRLRTLRRSLSHNQQYQAALALKDHLLMLPQLSQPRHIALYLPFDG
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
EPDTQPLIHALWQRGHRIALPRLHPFSSGHLLFLEYTPDTPMCHNRFGIAEPYLDVTRII
CCCHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
PLARLDLILTPLVAFDRQGHRLGMGGGFYDRTLQGWQQRHRLGVGPYPIGLAHDCQRVAA
HHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LPVAAWDVPLPEIITPQAHYRWPDAGAA
CCHHCCCCCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]