Click here to switch to the map view.

The map label for this gene is dsbC [H]

Identifier: 238921199

GI number: 238921199

Start: 3226607

End: 3227323

Strand: Reverse

Name: dsbC [H]

Synonym: NT01EI_3341

Alternate gene names: 238921199

Gene position: 3227323-3226607 (Counterclockwise)

Preceding gene: 238921200

Following gene: 238921198

Centisome position: 84.66

GC content: 57.32

Gene sequence:

>717_bases
ATGAAGAAAAGCGTGATTTGGTTGGCATTACTGGCGGCGTCCGTCAGCGGCCTGGCCCGGGCAGATGATGCCGCGATCCA
GCAGTCGCTGAAAAAGCTGGGGATCCAGCAGGCGCAGATTCAGGCGTCACCGGTGGCCGGTCTGAAGACGGTCTTCAGCG
AAGGCGGCGTGCTGTATGTTACGGACGATGGCAAGCATATCCTGCAGGGGCCAATGTATGACGTCAGCGGCGCGGTGCCG
GAGAACGTGACCAATCAGCTGCTGATGAAGCGCCTGGACAAGCTGGCTCCGGAGATGATCGTCTATAAGGCGCCGAAGCA
GAAGTATGTGATCACCGTCTTTACCGATATTACCTGCGGCTACTGCCATAAGCTGCACTCCCAGATTAAGGAGTACAACG
ATCTGGGGATCACCGTGCGCTATCTCGCCTTCCCGCGTCAGGGGCCGGACTCCAAGGCAGAGAAGGATATGCAGTCTATC
TGGTGCATGGCGGATCGCCGTAAAGCCTTTGACGATGCGCTGAAGGGGGAGACGATTTCACCAGCGACCTGTGATGTGAA
CATCAAGTCTCACTATGCGCTGGGCGTGCAGTTTGGCATTCAGGGTACACCGGCGATCGTGTTGAGCAACGGAATGGTGA
TCCCCGGCTATCAGGGGCCGAAAGAGATGCTGGCGATGCTGGATGCCCAGGCTCAGATGAGCCAGAAGAAAGGTTAA

Upstream 100 bases:

>100_bases
TACCCAGATTTATACCCATGTAGCGACAGAGCGTCTGCGACAGCTACATCAACAGCATCATCCCCGCGCCTGAGCGGAGG
GCAATTCAAAGGAATTCATT

Downstream 100 bases:

>100_bases
TGTTTTGACGATGAAGACACGGCTTTGCCGGCGAGAGGCGACGGCGGAGAGCCAGCTGCCGGACGGGATACCGCCGTTGC
TGCGCCGTCTGTACGGTAAC

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKKSVIWLALLAASVSGLARADDAAIQQSLKKLGIQQAQIQASPVAGLKTVFSEGGVLYVTDDGKHILQGPMYDVSGAVP
ENVTNQLLMKRLDKLAPEMIVYKAPKQKYVITVFTDITCGYCHKLHSQIKEYNDLGITVRYLAFPRQGPDSKAEKDMQSI
WCMADRRKAFDDALKGETISPATCDVNIKSHYALGVQFGIQGTPAIVLSNGMVIPGYQGPKEMLAMLDAQAQMSQKKG

Sequences:

>Translated_238_residues
MKKSVIWLALLAASVSGLARADDAAIQQSLKKLGIQQAQIQASPVAGLKTVFSEGGVLYVTDDGKHILQGPMYDVSGAVP
ENVTNQLLMKRLDKLAPEMIVYKAPKQKYVITVFTDITCGYCHKLHSQIKEYNDLGITVRYLAFPRQGPDSKAEKDMQSI
WCMADRRKAFDDALKGETISPATCDVNIKSHYALGVQFGIQGTPAIVLSNGMVIPGYQGPKEMLAMLDAQAQMSQKKG
>Mature_238_residues
MKKSVIWLALLAASVSGLARADDAAIQQSLKKLGIQQAQIQASPVAGLKTVFSEGGVLYVTDDGKHILQGPMYDVSGAVP
ENVTNQLLMKRLDKLAPEMIVYKAPKQKYVITVFTDITCGYCHKLHSQIKEYNDLGITVRYLAFPRQGPDSKAEKDMQSI
WCMADRRKAFDDALKGETISPATCDVNIKSHYALGVQFGIQGTPAIVLSNGMVIPGYQGPKEMLAMLDAQAQMSQKKG

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=237, Percent_Identity=64.9789029535865, Blast_Score=338, Evalue=3e-94,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 25965; Mature: 25965

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSVIWLALLAASVSGLARADDAAIQQSLKKLGIQQAQIQASPVAGLKTVFSEGGVLYV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCEEEE
TDDGKHILQGPMYDVSGAVPENVTNQLLMKRLDKLAPEMIVYKAPKQKYVITVFTDITCG
ECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEECCCCCEEEEEEECCHHH
YCHKLHSQIKEYNDLGITVRYLAFPRQGPDSKAEKDMQSIWCMADRRKAFDDALKGETIS
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PATCDVNIKSHYALGVQFGIQGTPAIVLSNGMVIPGYQGPKEMLAMLDAQAQMSQKKG
CCEEEEEECCCEEEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKSVIWLALLAASVSGLARADDAAIQQSLKKLGIQQAQIQASPVAGLKTVFSEGGVLYV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCEEEE
TDDGKHILQGPMYDVSGAVPENVTNQLLMKRLDKLAPEMIVYKAPKQKYVITVFTDITCG
ECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEECCCCCEEEEEEECCHHH
YCHKLHSQIKEYNDLGITVRYLAFPRQGPDSKAEKDMQSIWCMADRRKAFDDALKGETIS
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PATCDVNIKSHYALGVQFGIQGTPAIVLSNGMVIPGYQGPKEMLAMLDAQAQMSQKKG
CCEEEEEECCCEEEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270 [H]