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The map label for this gene is fdhF [H]

Identifier: 238921138

GI number: 238921138

Start: 3156946

End: 3158622

Strand: Direct

Name: fdhF [H]

Synonym: NT01EI_3279

Alternate gene names: 238921138

Gene position: 3156946-3158622 (Clockwise)

Preceding gene: 238921137

Following gene: 238921139

Centisome position: 82.81

GC content: 60.35

Gene sequence:

>1677_bases
ATGAGCAACTCCATCGTCGAACTTGAAGATACTGACTGCATTTTTGTCTTCGGCTACAACGCCGCGGACTCTCACCCCAT
CGTCGCCCGCCGCATCCTCCATGCGAAGGCGAAAGGGGCAAAAATCATTGTCTGCGATCCGCGGCGCATTGAAACCGCGC
GCATTGCCGACATCCACGTTCCATTGAAAAACGGCTCTAACATTGCGTTCCTCAACGCGATGGCGCAGGTGATCATCGCT
GAAAACCTGCACGATCGCGCATTTATCGAACGGCATACTGAAGAGTTTGACACCTTCCGCGAGCTGGTCGCCGCCTACAC
CCCGGAATCGGTTGAAGAGACCACCGGCATCAGCGCGCAGATGATCCGCGAGACGGCGCGGATGTATGCCAGGGCGCCCA
GCGCCACCATTCTGTGGGGCATGGGGGTTACCCAGTTCTATCAGGGGGTGGAGACCGTACGAACCCTGACCAGCATCGCG
CTGTTGACCGGCAACCTGGGCAAGCCCCACGTCGGCGTCGGCCCGGTGCGCGGGCAGAACAACGTACAGGGCGCCTGCGA
TATGGGCGCACTGCCCAATACTTTCCCTGGCTATCAGTATGTGGATCAGCCGGGCGTACTGGAGAAGTTTGCCAAGGCCT
GGGGCGTTGAAAAGCTGAACGACAAGATTGGCTACGCCCTGAGCGAGGTGCCGCACAATATCGATCATGGCCTGATCAAG
GCGCACTACGTGATGGGCGAAGATCCGCTGCAGACCGAACCGGATCTGGCCACCATTCGCCGCACCTTCGAGCAGCTCGA
TCTGCTGATCGTACAGGACATCTTCATGACCAAGACCGCGGCCATCGCCGACGTGATCTTCCCGGCCTCCAGCTGGGGTG
AACACGAAGGGGTATATACCTCCGCGGATCGCGGTTTCCAGCGCTTCTATAAAGCGGTGGAACCGGTGGGTGACGTGAAG
CGCGACTGGGAGATCATCGGCCTGATGTCAACGGCGATGGGCTACCCGATGCGCTACAGCGATACCCAGGAGATTTGGGA
CGAGCTGCGCGAGCTGTGCCCAATCTACTACGGCGCCACCTACGAGAAGATGGCGGATCTGGCCTATATCCAGTGGCCGT
GCCCGACGCTGGAAAGCCCCGGCACCCAGTACCTGTACCAGGGCGGTAAGTTCGACACCCCCAATGGCAAAGGCCAGTTC
TTTACCTGCGAATGGCACCCACCGATCGATCGCGTCAGCGACGACTATCCGCTGGTGCTGGCGACGGTACGCGAAGTGGG
TCATTACTCCTGTCGCTCCATGACCGGTAACTGCAAAGCGCTGGCCGCACTGGCCGACGAGCCTGGCTATGTCCAGATCA
ATACCGAGGACGCCAAAAACTTTGGCATCCGCGATCAGGATCTGGTGTGGATCCGCTCCCGCCAGGGCAAGGTCATCAGC
CGGGCGGCCGTCAGCGAGCGCGCCAACCGCGGGGCAGTCTACATGACCTACCAGTGGTGGATCGGCGCCTGTAACGAGCT
GGTCGCGGAGAACCTGAGTCCCATAACCAAGACGCCGGAATACAAATACTGCGCCGTCACCCTGGAGGCCATCGCCGATC
AGCCGGCGGCGGAAGCCTACGTGGAGCGCGAGTATGACAGTATCAAGCGGCATCTGCGCGAAAGCGCAGAGGGTTGA

Upstream 100 bases:

>100_bases
CGCCCGTGCGGCTATCGGTACTAACAATATCGACTGCTGCGCACGCGTCTGACACGGCCCTTCGGTTGCAGGTCTGCAGC
GATCGGTCGGTAACGGCGCC

Downstream 100 bases:

>100_bases
CGGGCTGCGGCTCTCAAAACAATAACGCGCCTTTAAACGCCTTATCAACGGAGTACGCGGCGGATTATCAAACTAACATG
CCGCGTATCACTTTTGATAA

Product: formate dehydrogenase, alpha subunit

Products: NA

Alternate protein names: Formate dehydrogenase-H subunit alpha; FDH-H; Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSNSIVELEDTDCIFVFGYNAADSHPIVARRILHAKAKGAKIIVCDPRRIETARIADIHVPLKNGSNIAFLNAMAQVIIA
ENLHDRAFIERHTEEFDTFRELVAAYTPESVEETTGISAQMIRETARMYARAPSATILWGMGVTQFYQGVETVRTLTSIA
LLTGNLGKPHVGVGPVRGQNNVQGACDMGALPNTFPGYQYVDQPGVLEKFAKAWGVEKLNDKIGYALSEVPHNIDHGLIK
AHYVMGEDPLQTEPDLATIRRTFEQLDLLIVQDIFMTKTAAIADVIFPASSWGEHEGVYTSADRGFQRFYKAVEPVGDVK
RDWEIIGLMSTAMGYPMRYSDTQEIWDELRELCPIYYGATYEKMADLAYIQWPCPTLESPGTQYLYQGGKFDTPNGKGQF
FTCEWHPPIDRVSDDYPLVLATVREVGHYSCRSMTGNCKALAALADEPGYVQINTEDAKNFGIRDQDLVWIRSRQGKVIS
RAAVSERANRGAVYMTYQWWIGACNELVAENLSPITKTPEYKYCAVTLEAIADQPAAEAYVEREYDSIKRHLRESAEG

Sequences:

>Translated_558_residues
MSNSIVELEDTDCIFVFGYNAADSHPIVARRILHAKAKGAKIIVCDPRRIETARIADIHVPLKNGSNIAFLNAMAQVIIA
ENLHDRAFIERHTEEFDTFRELVAAYTPESVEETTGISAQMIRETARMYARAPSATILWGMGVTQFYQGVETVRTLTSIA
LLTGNLGKPHVGVGPVRGQNNVQGACDMGALPNTFPGYQYVDQPGVLEKFAKAWGVEKLNDKIGYALSEVPHNIDHGLIK
AHYVMGEDPLQTEPDLATIRRTFEQLDLLIVQDIFMTKTAAIADVIFPASSWGEHEGVYTSADRGFQRFYKAVEPVGDVK
RDWEIIGLMSTAMGYPMRYSDTQEIWDELRELCPIYYGATYEKMADLAYIQWPCPTLESPGTQYLYQGGKFDTPNGKGQF
FTCEWHPPIDRVSDDYPLVLATVREVGHYSCRSMTGNCKALAALADEPGYVQINTEDAKNFGIRDQDLVWIRSRQGKVIS
RAAVSERANRGAVYMTYQWWIGACNELVAENLSPITKTPEYKYCAVTLEAIADQPAAEAYVEREYDSIKRHLRESAEG
>Mature_557_residues
SNSIVELEDTDCIFVFGYNAADSHPIVARRILHAKAKGAKIIVCDPRRIETARIADIHVPLKNGSNIAFLNAMAQVIIAE
NLHDRAFIERHTEEFDTFRELVAAYTPESVEETTGISAQMIRETARMYARAPSATILWGMGVTQFYQGVETVRTLTSIAL
LTGNLGKPHVGVGPVRGQNNVQGACDMGALPNTFPGYQYVDQPGVLEKFAKAWGVEKLNDKIGYALSEVPHNIDHGLIKA
HYVMGEDPLQTEPDLATIRRTFEQLDLLIVQDIFMTKTAAIADVIFPASSWGEHEGVYTSADRGFQRFYKAVEPVGDVKR
DWEIIGLMSTAMGYPMRYSDTQEIWDELRELCPIYYGATYEKMADLAYIQWPCPTLESPGTQYLYQGGKFDTPNGKGQFF
TCEWHPPIDRVSDDYPLVLATVREVGHYSCRSMTGNCKALAALADEPGYVQINTEDAKNFGIRDQDLVWIRSRQGKVISR
AAVSERANRGAVYMTYQWWIGACNELVAENLSPITKTPEYKYCAVTLEAIADQPAAEAYVEREYDSIKRHLRESAEG

Specific function: Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=558, Percent_Identity=69.7132616487455, Blast_Score=841, Evalue=0.0,
Organism=Escherichia coli, GI1788534, Length=638, Percent_Identity=23.5109717868339, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI3868719, Length=441, Percent_Identity=23.5827664399093, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI3868720, Length=442, Percent_Identity=23.9819004524887, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI87081797, Length=614, Percent_Identity=23.2899022801303, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787778, Length=206, Percent_Identity=29.6116504854369, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081994, Length=547, Percent_Identity=21.2065813528336, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI171474008, Length=631, Percent_Identity=22.9793977812995, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI145693196, Length=529, Percent_Identity=22.3062381852552, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787870, Length=616, Percent_Identity=22.4025974025974, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565758, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 62432; Mature: 62301

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSIVELEDTDCIFVFGYNAADSHPIVARRILHAKAKGAKIIVCDPRRIETARIADIHV
CCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEE
PLKNGSNIAFLNAMAQVIIAENLHDRAFIERHTEEFDTFRELVAAYTPESVEETTGISAQ
ECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHH
MIRETARMYARAPSATILWGMGVTQFYQGVETVRTLTSIALLTGNLGKPHVGVGPVRGQN
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVQGACDMGALPNTFPGYQYVDQPGVLEKFAKAWGVEKLNDKIGYALSEVPHNIDHGLIK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEE
AHYVMGEDPLQTEPDLATIRRTFEQLDLLIVQDIFMTKTAAIADVIFPASSWGEHEGVYT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
SADRGFQRFYKAVEPVGDVKRDWEIIGLMSTAMGYPMRYSDTQEIWDELRELCPIYYGAT
CHHHHHHHHHHHHCCHHHHHHCHHHEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
YEKMADLAYIQWPCPTLESPGTQYLYQGGKFDTPNGKGQFFTCEWHPPIDRVSDDYPLVL
HHHHHCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCHHH
ATVREVGHYSCRSMTGNCKALAALADEPGYVQINTEDAKNFGIRDQDLVWIRSRQGKVIS
HHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCHHH
RAAVSERANRGAVYMTYQWWIGACNELVAENLSPITKTPEYKYCAVTLEAIADQPAAEAY
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCHHHHHH
VEREYDSIKRHLRESAEG
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNSIVELEDTDCIFVFGYNAADSHPIVARRILHAKAKGAKIIVCDPRRIETARIADIHV
CCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEE
PLKNGSNIAFLNAMAQVIIAENLHDRAFIERHTEEFDTFRELVAAYTPESVEETTGISAQ
ECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHH
MIRETARMYARAPSATILWGMGVTQFYQGVETVRTLTSIALLTGNLGKPHVGVGPVRGQN
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVQGACDMGALPNTFPGYQYVDQPGVLEKFAKAWGVEKLNDKIGYALSEVPHNIDHGLIK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEE
AHYVMGEDPLQTEPDLATIRRTFEQLDLLIVQDIFMTKTAAIADVIFPASSWGEHEGVYT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
SADRGFQRFYKAVEPVGDVKRDWEIIGLMSTAMGYPMRYSDTQEIWDELRELCPIYYGAT
CHHHHHHHHHHHHCCHHHHHHCHHHEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
YEKMADLAYIQWPCPTLESPGTQYLYQGGKFDTPNGKGQFFTCEWHPPIDRVSDDYPLVL
HHHHHCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCHHH
ATVREVGHYSCRSMTGNCKALAALADEPGYVQINTEDAKNFGIRDQDLVWIRSRQGKVIS
HHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCHHH
RAAVSERANRGAVYMTYQWWIGACNELVAENLSPITKTPEYKYCAVTLEAIADQPAAEAY
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCHHHHHH
VEREYDSIKRHLRESAEG
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2941757; 8265357; 9278503; 2211698; 9036855 [H]