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The map label for this gene is emrA [H]

Identifier: 238920964

GI number: 238920964

Start: 2981308

End: 2982486

Strand: Direct

Name: emrA [H]

Synonym: NT01EI_3094

Alternate gene names: 238920964

Gene position: 2981308-2982486 (Clockwise)

Preceding gene: 238920963

Following gene: 238920965

Centisome position: 78.2

GC content: 59.54

Gene sequence:

>1179_bases
ATGAGTGAAAACCTGGCGACACAGGCAACCCAGCAGCCTGCACCCAATAATAAAAAGAAACAGCGTAAAACCTGGATGCT
AGGGATGACCAGCGTGTTCATCCTGATCGCCGCTGCCTACCTGGTCTATTGGTTTATCGTTCTGCGTTACCATCAAGAGA
CCGACGATGCCTATGTCACCGGTAACCGTGTACAGATCAACGCTCAGGTCTCCGGCAGCGTGACCCGGGTCAACTTTGAA
GGCACCGATCTGGTGAGGGCTGGCGATACCCTGGTCACACTGGATAAAACCGATGCCCAGCAGGCCTATGAGCGGGCGAA
AACCGCACTGGCCAACAGTGTGCGCCAAACCCACCAGCTGATGGTTAACGCCAAACAGTACCAGGCCAACATCGCGGTGA
GTCAGGTAGCGCTGAGCAAAGCCAGCAACGACTACCAGCGCCGCCTGGCACTGAGCCGCTCCGGCGCCATTGGCCGCGAA
GAGTTACAGCATGCGCAGGACGCCATGGAGAGCGCCCGTGCCGCGCTGGACGTCGCTATCCAGCAGTACAACGCCAATCA
GGCGCTAATCCTGAATACTCCGCTGGAAAAACAGCCGGTCGTGCTGCAGGCCGCCGCTCAGGTGCGCGACGCCTGGCTGG
CGCTGGAGCGTACCCAGATCCGCAGCCCGGTGACCGGCTATGTCTCCCAGCGTAGTGTACAGGTCGGCGCTCAAATCAGC
CCCAACACACCGCTGATGGCCATTGTTCCTGCCAGTCAGATGTGGGTAGATGCCAATTTTAAAGAGACCCAGCTGGCCAA
TATGCGTATCGGCCAACCGGCCACCGTCGTCAGCGATATGTACGGCGACGGCGTGGTCTTTAAAGGTAAAGTGGCCGGTC
TGGATATGGGCACCGGCAGCGCCTTCTCTCTGCTGCCGGCACAGAACGCCACCGGCAACTGGATCAAGGTCGTACAGCGC
CTGCCGGTACGCATTGAGCTTGATCCTCAGCAACTGGCGCAGTATCCGCTGCGCATCGGGCTTTCCACGTTGGTCACCGT
CGACACTGCCGATATCCGCGGCGAGGTACTGGCCCAGCAGGTGCGTAAGACGCCAGCCTACCAGAGCAATGTACTGACAC
TGGACCTGGCACCGGTGAATCGCGAGATCGCCGGGATCATCCAGGCCAACGCCGCTTAA

Upstream 100 bases:

>100_bases
GGCACGGCTGCAGTGGTTGCCAGCGTACGGCAGCGGGGAGAATTCGATTGAACTATCCATTATATGACTATGGTTCCAAA
AGGAAATATGGAGAAACACC

Downstream 100 bases:

>100_bases
TCTGCGCCGAGGTGACTGTGCAACAAAAACCACTTGAGGGAGCCAAACTTGCATGGATGACCATCGCGCTGTCGATGGCC
ACCTTCATGCAGGTGCTGGA

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSENLATQATQQPAPNNKKKQRKTWMLGMTSVFILIAAAYLVYWFIVLRYHQETDDAYVTGNRVQINAQVSGSVTRVNFE
GTDLVRAGDTLVTLDKTDAQQAYERAKTALANSVRQTHQLMVNAKQYQANIAVSQVALSKASNDYQRRLALSRSGAIGRE
ELQHAQDAMESARAALDVAIQQYNANQALILNTPLEKQPVVLQAAAQVRDAWLALERTQIRSPVTGYVSQRSVQVGAQIS
PNTPLMAIVPASQMWVDANFKETQLANMRIGQPATVVSDMYGDGVVFKGKVAGLDMGTGSAFSLLPAQNATGNWIKVVQR
LPVRIELDPQQLAQYPLRIGLSTLVTVDTADIRGEVLAQQVRKTPAYQSNVLTLDLAPVNREIAGIIQANAA

Sequences:

>Translated_392_residues
MSENLATQATQQPAPNNKKKQRKTWMLGMTSVFILIAAAYLVYWFIVLRYHQETDDAYVTGNRVQINAQVSGSVTRVNFE
GTDLVRAGDTLVTLDKTDAQQAYERAKTALANSVRQTHQLMVNAKQYQANIAVSQVALSKASNDYQRRLALSRSGAIGRE
ELQHAQDAMESARAALDVAIQQYNANQALILNTPLEKQPVVLQAAAQVRDAWLALERTQIRSPVTGYVSQRSVQVGAQIS
PNTPLMAIVPASQMWVDANFKETQLANMRIGQPATVVSDMYGDGVVFKGKVAGLDMGTGSAFSLLPAQNATGNWIKVVQR
LPVRIELDPQQLAQYPLRIGLSTLVTVDTADIRGEVLAQQVRKTPAYQSNVLTLDLAPVNREIAGIIQANAA
>Mature_391_residues
SENLATQATQQPAPNNKKKQRKTWMLGMTSVFILIAAAYLVYWFIVLRYHQETDDAYVTGNRVQINAQVSGSVTRVNFEG
TDLVRAGDTLVTLDKTDAQQAYERAKTALANSVRQTHQLMVNAKQYQANIAVSQVALSKASNDYQRRLALSRSGAIGREE
LQHAQDAMESARAALDVAIQQYNANQALILNTPLEKQPVVLQAAAQVRDAWLALERTQIRSPVTGYVSQRSVQVGAQISP
NTPLMAIVPASQMWVDANFKETQLANMRIGQPATVVSDMYGDGVVFKGKVAGLDMGTGSAFSLLPAQNATGNWIKVVQRL
PVRIELDPQQLAQYPLRIGLSTLVTVDTADIRGEVLAQQVRKTPAYQSNVLTLDLAPVNREIAGIIQANAA

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=392, Percent_Identity=66.8367346938776, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1788711, Length=381, Percent_Identity=53.8057742782152, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI87081951, Length=305, Percent_Identity=30.1639344262295, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790519, Length=319, Percent_Identity=27.5862068965517, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789637, Length=336, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790024, Length=237, Percent_Identity=27.8481012658228, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42857; Mature: 42726

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENLATQATQQPAPNNKKKQRKTWMLGMTSVFILIAAAYLVYWFIVLRYHQETDDAYVT
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GNRVQINAQVSGSVTRVNFEGTDLVRAGDTLVTLDKTDAQQAYERAKTALANSVRQTHQL
CCEEEEEEEECCCEEEEEECCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MVNAKQYQANIAVSQVALSKASNDYQRRLALSRSGAIGREELQHAQDAMESARAALDVAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QQYNANQALILNTPLEKQPVVLQAAAQVRDAWLALERTQIRSPVTGYVSQRSVQVGAQIS
HHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCEEC
PNTPLMAIVPASQMWVDANFKETQLANMRIGQPATVVSDMYGDGVVFKGKVAGLDMGTGS
CCCCEEEEECCCCEEEECCCCHHEECCEECCCCHHHHHHHCCCCEEEEEEEEEEECCCCC
AFSLLPAQNATGNWIKVVQRLPVRIELDPQQLAQYPLRIGLSTLVTVDTADIRGEVLAQQ
CEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHH
VRKTPAYQSNVLTLDLAPVNREIAGIIQANAA
HHCCCCCCCCEEEEEECCCCCHHHEEEECCCC
>Mature Secondary Structure 
SENLATQATQQPAPNNKKKQRKTWMLGMTSVFILIAAAYLVYWFIVLRYHQETDDAYVT
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GNRVQINAQVSGSVTRVNFEGTDLVRAGDTLVTLDKTDAQQAYERAKTALANSVRQTHQL
CCEEEEEEEECCCEEEEEECCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MVNAKQYQANIAVSQVALSKASNDYQRRLALSRSGAIGREELQHAQDAMESARAALDVAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QQYNANQALILNTPLEKQPVVLQAAAQVRDAWLALERTQIRSPVTGYVSQRSVQVGAQIS
HHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCEEC
PNTPLMAIVPASQMWVDANFKETQLANMRIGQPATVVSDMYGDGVVFKGKVAGLDMGTGS
CCCCEEEEECCCCEEEECCCCHHEECCEECCCCHHHHHHHCCCCEEEEEEEEEEECCCCC
AFSLLPAQNATGNWIKVVQRLPVRIELDPQQLAQYPLRIGLSTLVTVDTADIRGEVLAQQ
CEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHH
VRKTPAYQSNVLTLDLAPVNREIAGIIQANAA
HHCCCCCCCCEEEEEECCCCCHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]