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The map label for this gene is holA [H]

Identifier: 238920812

GI number: 238920812

Start: 2826866

End: 2827900

Strand: Direct

Name: holA [H]

Synonym: NT01EI_2938

Alternate gene names: 238920812

Gene position: 2826866-2827900 (Clockwise)

Preceding gene: 238920811

Following gene: 238920813

Centisome position: 74.15

GC content: 64.35

Gene sequence:

>1035_bases
ATGAGCCGGATTTACCCCGAACAGCTCGGCGCACAGCTGCAGGACGGGTTGCGCGCCTGCTACTTCATTCTGGGAAACGA
GCCGCTGCTGATCCAGGAGAGTCTGGATCTGATCCGCCAGCGCGCCCGCGCCCACGGTTTTGATGAACAGTTCAGCGCCA
CCCTCGATCCCCACACTGACTGGGATGCGCTGTTCAGCCGGTCCCAGTCAATGAGCCTGTTCGCCAGCCGTCAAATCCTC
ACCCTGACCCTGCCGGACAACGGCGTCAATGCCGCGATGGGCGAACGTCTGAGTCAGCTTGCCACCCTACTCCACCCGGA
TCTGCTGCTGCTGCTGCGCGGCCCGCGCCTGACCCGCACCCAGGAAAACGCAGCCTGGTATAAACAGCTCAGCCCACAGG
CTACCCTGGTCAGTTGCCAGACGCCGGAGCAGACCCAGCTGCCGCGCTGGGTCGCCAACCGCGCACGCCAGATGCAGCTG
CAGCTCGACGAGGCGGCGCTACAGCTGCTGTGCTACTGCTATGAGGGCAACCTGCTGGCGCTCACCCAGGCGCTGGGGCG
ACTCTCTCTGCTCTATCCCGACGGGCGGCTGACCCTGCCGCGCGTCGAGCAGGCGGTCAACGATGCAGCCCACTTCTCAC
CGTTCCACTGGCTGGACGCCTGCTTAGCGGCGCGCAGCAAGCGCGCCTGGCATATACTGAACCAGCTGCGCCAGGAGGGC
TGCGAGCCGATAGTGCTGGTGCGCACCGTACAGCGCGAGCTTCTGCTGCTGCTGCAGCTCAAGGGAGGCGCGGCGCAGAC
ACCTCTGCGCACGCTGTTCGATAAGCATAAGGTGTGGCAAAACCGCCGCCCGCTGCTGACCCAGGCGATGCAAACCCTAT
CTCTGCCCCAGCTGCACCAGGCCGTGGCGCTGCTGAGCCAGTGCGAACAGATAATCAAACAGGATTTCGGCCAGTCCGTA
TGGCCCCAGCTGGAGTCCCTGACCCTACTACTGTGCGGCAAGACGCTGCCGGAGAGTATGCTGCATGTCGAGTGA

Upstream 100 bases:

>100_bases
GCGACGTCAGCGCACCCAGGGTTCAGGGCAGCAACGACTTTGAACGGGTCAACACCGGCGTTATCGCTACGCCGGCCGCA
CAGGCCGGACAGCAGGAAAA

Downstream 100 bases:

>100_bases
ATCCCAACCGGCGGTGCCATCCCTGCTGGCGCTGTTCGGCGGCACCTTCGATCCTATTCATTATGGTCACCTCAAGCCAG
TCACGGCGCTGGCACAGGAG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSRIYPEQLGAQLQDGLRACYFILGNEPLLIQESLDLIRQRARAHGFDEQFSATLDPHTDWDALFSRSQSMSLFASRQIL
TLTLPDNGVNAAMGERLSQLATLLHPDLLLLLRGPRLTRTQENAAWYKQLSPQATLVSCQTPEQTQLPRWVANRARQMQL
QLDEAALQLLCYCYEGNLLALTQALGRLSLLYPDGRLTLPRVEQAVNDAAHFSPFHWLDACLAARSKRAWHILNQLRQEG
CEPIVLVRTVQRELLLLLQLKGGAAQTPLRTLFDKHKVWQNRRPLLTQAMQTLSLPQLHQAVALLSQCEQIIKQDFGQSV
WPQLESLTLLLCGKTLPESMLHVE

Sequences:

>Translated_344_residues
MSRIYPEQLGAQLQDGLRACYFILGNEPLLIQESLDLIRQRARAHGFDEQFSATLDPHTDWDALFSRSQSMSLFASRQIL
TLTLPDNGVNAAMGERLSQLATLLHPDLLLLLRGPRLTRTQENAAWYKQLSPQATLVSCQTPEQTQLPRWVANRARQMQL
QLDEAALQLLCYCYEGNLLALTQALGRLSLLYPDGRLTLPRVEQAVNDAAHFSPFHWLDACLAARSKRAWHILNQLRQEG
CEPIVLVRTVQRELLLLLQLKGGAAQTPLRTLFDKHKVWQNRRPLLTQAMQTLSLPQLHQAVALLSQCEQIIKQDFGQSV
WPQLESLTLLLCGKTLPESMLHVE
>Mature_343_residues
SRIYPEQLGAQLQDGLRACYFILGNEPLLIQESLDLIRQRARAHGFDEQFSATLDPHTDWDALFSRSQSMSLFASRQILT
LTLPDNGVNAAMGERLSQLATLLHPDLLLLLRGPRLTRTQENAAWYKQLSPQATLVSCQTPEQTQLPRWVANRARQMQLQ
LDEAALQLLCYCYEGNLLALTQALGRLSLLYPDGRLTLPRVEQAVNDAAHFSPFHWLDACLAARSKRAWHILNQLRQEGC
EPIVLVRTVQRELLLLLQLKGGAAQTPLRTLFDKHKVWQNRRPLLTQAMQTLSLPQLHQAVALLSQCEQIIKQDFGQSVW
PQLESLTLLLCGKTLPESMLHVE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=341, Percent_Identity=63.6363636363636, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39006; Mature: 38875

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIYPEQLGAQLQDGLRACYFILGNEPLLIQESLDLIRQRARAHGFDEQFSATLDPHTD
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHCCCCCCCCC
WDALFSRSQSMSLFASRQILTLTLPDNGVNAAMGERLSQLATLLHPDLLLLLRGPRLTRT
HHHHHCCCCHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCC
QENAAWYKQLSPQATLVSCQTPEQTQLPRWVANRARQMQLQLDEAALQLLCYCYEGNLLA
CHHHHHHHHCCCCCEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LTQALGRLSLLYPDGRLTLPRVEQAVNDAAHFSPFHWLDACLAARSKRAWHILNQLRQEG
HHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCC
CEPIVLVRTVQRELLLLLQLKGGAAQTPLRTLFDKHKVWQNRRPLLTQAMQTLSLPQLHQ
CCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHH
AVALLSQCEQIIKQDFGQSVWPQLESLTLLLCGKTLPESMLHVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure 
SRIYPEQLGAQLQDGLRACYFILGNEPLLIQESLDLIRQRARAHGFDEQFSATLDPHTD
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHCCCCCCCCC
WDALFSRSQSMSLFASRQILTLTLPDNGVNAAMGERLSQLATLLHPDLLLLLRGPRLTRT
HHHHHCCCCHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCC
QENAAWYKQLSPQATLVSCQTPEQTQLPRWVANRARQMQLQLDEAALQLLCYCYEGNLLA
CHHHHHHHHCCCCCEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LTQALGRLSLLYPDGRLTLPRVEQAVNDAAHFSPFHWLDACLAARSKRAWHILNQLRQEG
HHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCC
CEPIVLVRTVQRELLLLLQLKGGAAQTPLRTLFDKHKVWQNRRPLLTQAMQTLSLPQLHQ
CCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHH
AVALLSQCEQIIKQDFGQSVWPQLESLTLLLCGKTLPESMLHVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]