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The map label for this gene is phoR [H]

Identifier: 238917551

GI number: 238917551

Start: 1688075

End: 1689391

Strand: Reverse

Name: phoR [H]

Synonym: EUBELI_01630

Alternate gene names: 238917551

Gene position: 1689391-1688075 (Counterclockwise)

Preceding gene: 238917552

Following gene: 238917550

Centisome position: 78.79

GC content: 37.28

Gene sequence:

>1317_bases
ATGAAGCAGAAGATTAATTTAAGGCTTATTGGAATAGCAGTTATAGCAGTTCTTGCTACAGCTATTGGAATAACTTTTAT
ATATTATGGGTTGTTTAAGAAACAGGTCCAGGCCGGATTGAGAACTAATGCAGAAGTACTCATGGAAACGGGAGTTTTTG
AAAAGTCAGCGCAATATGCAGATGTAAAGCTTCCAATTAATAATCTCAGGGTTACTTGGATAGATTCAGATGGGGTGGTG
CTTTTTGATAATGATAATGATATTAATGTAATGCCTAATCATAAAGACAGACCTGAGATACAGGACGCATTTCATACCGG
ACATGGTCAGTGTGTAAGAAATTCTGACACGATGGATATGAATACCTTTTATTATGCTCTAAAACAGAAGGATGGGACTG
TTATAAGAGTATCCTGTGATGCAAGCAGTTTATTAAGTGTGTTTGGCAATGTATTTCCGGCTGTAACAGGAATACTTGCA
GTAATTATAGTAGTGTGTATCGTTCTTTCACAATTACTTACAAGGACACTTATTGAGCCTATTGAAAGAATGGCTAAGAA
TATGGATTCCGTACAGGAGAAGCCTGTATATAAAGAAATAGCCCCTTTTGCAGAGAAAATCAGGACACAGCATGAGAATA
TTCTTGCTGCTGCAAGAAGCCGACAGGATTTTACTGCAAATGTATCACATGAATTAAAGACTCCTCTTACCGCAATCTCA
GGCTATGCAGAGCTTATTGAGAATGAGATGGTAAGTCATGAACAGGGGATACATTTTGCACATGAGATTAAGCGTAATTC
AGAAAGATTATTATCATTAATTAATGATATTATAAGGCTTTCAGAATTAGACCACAGCGAAATGCCAAGACAGTATGAGA
ATTTTGATTTATATGAGTTTGTTAAGGATTGTGCAGAGTCTCTGCAGGTTAATGCACAGAAACAAGGAATATATTTTTCA
TATAGAGGTTCAGCCTGCATGATCCGCGGCAATAAGGATATGATAAGAGAGCTTATTGATAATCTTGTACAGAATGCAAT
AAGATACAATAAAGAAGGTGGACATGTGGAAGTGTTTGCGGGAATGGTAGATGGGAAGCCAAGGCTAGAGGTAACTGATG
ATGGAATAGGAATTCCTAAGGATCAGCAGGACAGGGTGTTTGAAAGATTTTACAGAGTTGACAAGAGCCGATCAAAGGAA
ACTGGTGGAACAGGACTCGGTCTTGCTATTGTAAAGCATATTGTTGAACTTCATGATGCAAGAATTTATCTTGACAGTGA
AATTAATAAGGGAACTGTAATACGGATTGAATTCTGA

Upstream 100 bases:

>100_bases
AGAAGTTGGGTGATGCAGGCTCGCGTATAAGAACCGTGCGTAATGTAGGATATGTTATAGAGTAGCCTGATATAATTAAC
AGACAGAACAGGGTGGATAT

Downstream 100 bases:

>100_bases
CATAATACGGATGATATACAGATTATTAAATTGTATATCATCCATTTTTTCTTTTACAAGTGGAATGAATTGTTATATTA
TAATGTGTATTGAATATAAT

Product: two-component system OmpR family sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKQKINLRLIGIAVIAVLATAIGITFIYYGLFKKQVQAGLRTNAEVLMETGVFEKSAQYADVKLPINNLRVTWIDSDGVV
LFDNDNDINVMPNHKDRPEIQDAFHTGHGQCVRNSDTMDMNTFYYALKQKDGTVIRVSCDASSLLSVFGNVFPAVTGILA
VIIVVCIVLSQLLTRTLIEPIERMAKNMDSVQEKPVYKEIAPFAEKIRTQHENILAAARSRQDFTANVSHELKTPLTAIS
GYAELIENEMVSHEQGIHFAHEIKRNSERLLSLINDIIRLSELDHSEMPRQYENFDLYEFVKDCAESLQVNAQKQGIYFS
YRGSACMIRGNKDMIRELIDNLVQNAIRYNKEGGHVEVFAGMVDGKPRLEVTDDGIGIPKDQQDRVFERFYRVDKSRSKE
TGGTGLGLAIVKHIVELHDARIYLDSEINKGTVIRIEF

Sequences:

>Translated_438_residues
MKQKINLRLIGIAVIAVLATAIGITFIYYGLFKKQVQAGLRTNAEVLMETGVFEKSAQYADVKLPINNLRVTWIDSDGVV
LFDNDNDINVMPNHKDRPEIQDAFHTGHGQCVRNSDTMDMNTFYYALKQKDGTVIRVSCDASSLLSVFGNVFPAVTGILA
VIIVVCIVLSQLLTRTLIEPIERMAKNMDSVQEKPVYKEIAPFAEKIRTQHENILAAARSRQDFTANVSHELKTPLTAIS
GYAELIENEMVSHEQGIHFAHEIKRNSERLLSLINDIIRLSELDHSEMPRQYENFDLYEFVKDCAESLQVNAQKQGIYFS
YRGSACMIRGNKDMIRELIDNLVQNAIRYNKEGGHVEVFAGMVDGKPRLEVTDDGIGIPKDQQDRVFERFYRVDKSRSKE
TGGTGLGLAIVKHIVELHDARIYLDSEINKGTVIRIEF
>Mature_438_residues
MKQKINLRLIGIAVIAVLATAIGITFIYYGLFKKQVQAGLRTNAEVLMETGVFEKSAQYADVKLPINNLRVTWIDSDGVV
LFDNDNDINVMPNHKDRPEIQDAFHTGHGQCVRNSDTMDMNTFYYALKQKDGTVIRVSCDASSLLSVFGNVFPAVTGILA
VIIVVCIVLSQLLTRTLIEPIERMAKNMDSVQEKPVYKEIAPFAEKIRTQHENILAAARSRQDFTANVSHELKTPLTAIS
GYAELIENEMVSHEQGIHFAHEIKRNSERLLSLINDIIRLSELDHSEMPRQYENFDLYEFVKDCAESLQVNAQKQGIYFS
YRGSACMIRGNKDMIRELIDNLVQNAIRYNKEGGHVEVFAGMVDGKPRLEVTDDGIGIPKDQQDRVFERFYRVDKSRSKE
TGGTGLGLAIVKHIVELHDARIYLDSEINKGTVIRIEF

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=34.4827586206897, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=29.3478260869565, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=30.6666666666667, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786783, Length=282, Percent_Identity=24.822695035461, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=27.2340425531915, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=204, Percent_Identity=29.9019607843137, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=29.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=23.1292517006803, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790861, Length=390, Percent_Identity=23.5897435897436, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=25.8503401360544, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=23.5807860262009, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=26.605504587156, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=30.2752293577982, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787894, Length=203, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=24.1258741258741, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=25.2595155709343, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=206, Percent_Identity=28.1553398058252, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=209, Percent_Identity=22.488038277512, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=24.6212121212121, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49472; Mature: 49472

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKINLRLIGIAVIAVLATAIGITFIYYGLFKKQVQAGLRTNAEVLMETGVFEKSAQYA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCE
DVKLPINNLRVTWIDSDGVVLFDNDNDINVMPNHKDRPEIQDAFHTGHGQCVRNSDTMDM
EEEEECCCEEEEEECCCCEEEEECCCCEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCH
NTFYYALKQKDGTVIRVSCDASSLLSVFGNVFPAVTGILAVIIVVCIVLSQLLTRTLIEP
HHHEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IERMAKNMDSVQEKPVYKEIAPFAEKIRTQHENILAAARSRQDFTANVSHELKTPLTAIS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHHH
GYAELIENEMVSHEQGIHFAHEIKRNSERLLSLINDIIRLSELDHSEMPRQYENFDLYEF
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCHHCCCCHHHH
VKDCAESLQVNAQKQGIYFSYRGSACMIRGNKDMIRELIDNLVQNAIRYNKEGGHVEVFA
HHHHHHHHHCCCHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GMVDGKPRLEVTDDGIGIPKDQQDRVFERFYRVDKSRSKETGGTGLGLAIVKHIVELHDA
EEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
RIYLDSEINKGTVIRIEF
EEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MKQKINLRLIGIAVIAVLATAIGITFIYYGLFKKQVQAGLRTNAEVLMETGVFEKSAQYA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCE
DVKLPINNLRVTWIDSDGVVLFDNDNDINVMPNHKDRPEIQDAFHTGHGQCVRNSDTMDM
EEEEECCCEEEEEECCCCEEEEECCCCEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCH
NTFYYALKQKDGTVIRVSCDASSLLSVFGNVFPAVTGILAVIIVVCIVLSQLLTRTLIEP
HHHEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IERMAKNMDSVQEKPVYKEIAPFAEKIRTQHENILAAARSRQDFTANVSHELKTPLTAIS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHHH
GYAELIENEMVSHEQGIHFAHEIKRNSERLLSLINDIIRLSELDHSEMPRQYENFDLYEF
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCHHCCCCHHHH
VKDCAESLQVNAQKQGIYFSYRGSACMIRGNKDMIRELIDNLVQNAIRYNKEGGHVEVFA
HHHHHHHHHCCCHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GMVDGKPRLEVTDDGIGIPKDQQDRVFERFYRVDKSRSKETGGTGLGLAIVKHIVELHDA
EEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
RIYLDSEINKGTVIRIEF
EEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]