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The map label for this gene is glxR [H]

Identifier: 238893470

GI number: 238893470

Start: 1315448

End: 1316326

Strand: Direct

Name: glxR [H]

Synonym: KP1_1363

Alternate gene names: 238893470

Gene position: 1315448-1316326 (Clockwise)

Preceding gene: 238893469

Following gene: 238893471

Centisome position: 25.06

GC content: 51.54

Gene sequence:

>879_bases
ATGAAGCTGGGATTTATTGGTTTGGGGATTATGGGCACCCCGATGGCGCTCCGTCTTGCCAAAGCAGGCCACGCACTGCA
CGTTACCACTATTGGGCCTGTTGCTGACGAATTGCTCAAGCACGGGGCACAACATCTGGCCTGCGCAGAACAGGTGGCGG
AGCAGTCAGACATTATTTTTATTATGGTACCCGATACCCCGCAGGTTGCCGAGGTGCTGTTTGGCGAACATGGTTGTGCT
AAAGCGGTTCTGAAGGGCAAAATTATTGTGGATATGAGTTCTATCTCGCCGATAGAAACGAAACGTTTTGCGCAGCAGGT
GCGGGATCTGGGCGCCGATTACCTTGATGCGCCGGTCTCCGGCGGCGAAATTGGCGCACGTGAAGGCACGCTCTCCATTA
TGGTTGGCGGCGATGAAAATATCTTTGCCCGCGTGAAACCGCTGTTTGATATTTTGGGTAAAAATATCACCCTCGTCGGA
GGGAACGGCGACGGTCAGACCTGTAAAGTCGCCAATCAAATTATTGTCGCGCTGAATATTGAAGCGGTGTCCGAAGCGCT
GGTTTTTGCCTCTAAAGCCGGGGCGGACCCTGCTCGCGTTCGTCAGGCTTTGATGGGCGGTTTCGCTTCCTCACGTATTC
TGGAAGTGCACGGTGAAAGAATGCTCAACCGCACCTTTAATCCAGGCTTTAAAATTTCTCTGCACCAGAAGGATCTCAAT
CTGGCTCTGCAGAGCGCTAAAGCCCTGGCGCTTAATCTGCCGAATACTGCTACCTGTCAGGAACTTTTTAATACTTGTGC
CGCCAATGGAGGGAGCGAGTTAGATCATTCGTCTCTGATTCAGGCTCTGGAATTAATGGCAAATCATCAAATAGCGTAA

Upstream 100 bases:

>100_bases
CAGTATTTATTATTCCAGACGCAGGGGATTTATTTCCTGACAACCGGAAGGGATAGCTATTGCCCAGATAAATCGAAATA
TACATTGTGAGAGGATACTT

Downstream 100 bases:

>100_bases
TAAGCGTAAAGCTGCCGAAACCAGCAGCTTTATTTGAACCTCACAGGTGACTTTATGGATACAATCAATAACAAAGGTGT
CGACTATTGGAAGAAAATAG

Product: putative oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKLGFIGLGIMGTPMALRLAKAGHALHVTTIGPVADELLKHGAQHLACAEQVAEQSDIIFIMVPDTPQVAEVLFGEHGCA
KAVLKGKIIVDMSSISPIETKRFAQQVRDLGADYLDAPVSGGEIGAREGTLSIMVGGDENIFARVKPLFDILGKNITLVG
GNGDGQTCKVANQIIVALNIEAVSEALVFASKAGADPARVRQALMGGFASSRILEVHGERMLNRTFNPGFKISLHQKDLN
LALQSAKALALNLPNTATCQELFNTCAANGGSELDHSSLIQALELMANHQIA

Sequences:

>Translated_292_residues
MKLGFIGLGIMGTPMALRLAKAGHALHVTTIGPVADELLKHGAQHLACAEQVAEQSDIIFIMVPDTPQVAEVLFGEHGCA
KAVLKGKIIVDMSSISPIETKRFAQQVRDLGADYLDAPVSGGEIGAREGTLSIMVGGDENIFARVKPLFDILGKNITLVG
GNGDGQTCKVANQIIVALNIEAVSEALVFASKAGADPARVRQALMGGFASSRILEVHGERMLNRTFNPGFKISLHQKDLN
LALQSAKALALNLPNTATCQELFNTCAANGGSELDHSSLIQALELMANHQIA
>Mature_292_residues
MKLGFIGLGIMGTPMALRLAKAGHALHVTTIGPVADELLKHGAQHLACAEQVAEQSDIIFIMVPDTPQVAEVLFGEHGCA
KAVLKGKIIVDMSSISPIETKRFAQQVRDLGADYLDAPVSGGEIGAREGTLSIMVGGDENIFARVKPLFDILGKNITLVG
GNGDGQTCKVANQIIVALNIEAVSEALVFASKAGADPARVRQALMGGFASSRILEVHGERMLNRTFNPGFKISLHQKDLN
LALQSAKALALNLPNTATCQELFNTCAANGGSELDHSSLIQALELMANHQIA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=300, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=26.8551236749117, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=86.986301369863, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=43.1506849315069, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1790315, Length=289, Percent_Identity=30.4498269896194, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=28.0701754385965, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=257, Percent_Identity=33.4630350194552, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24655230, Length=283, Percent_Identity=34.982332155477, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19922568, Length=283, Percent_Identity=34.982332155477, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=28.4697508896797, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30809; Mature: 30809

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGFIGLGIMGTPMALRLAKAGHALHVTTIGPVADELLKHGAQHLACAEQVAEQSDIIF
CCEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IMVPDTPQVAEVLFGEHGCAKAVLKGKIIVDMSSISPIETKRFAQQVRDLGADYLDAPVS
EEECCCHHHHHHHHCCCCHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHCCCCC
GGEIGAREGTLSIMVGGDENIFARVKPLFDILGKNITLVGGNGDGQTCKVANQIIVALNI
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCEEEEEEEH
EAVSEALVFASKAGADPARVRQALMGGFASSRILEVHGERMLNRTFNPGFKISLHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
LALQSAKALALNLPNTATCQELFNTCAANGGSELDHSSLIQALELMANHQIA
HHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLGFIGLGIMGTPMALRLAKAGHALHVTTIGPVADELLKHGAQHLACAEQVAEQSDIIF
CCEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IMVPDTPQVAEVLFGEHGCAKAVLKGKIIVDMSSISPIETKRFAQQVRDLGADYLDAPVS
EEECCCHHHHHHHHCCCCHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHCCCCC
GGEIGAREGTLSIMVGGDENIFARVKPLFDILGKNITLVGGNGDGQTCKVANQIIVALNI
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCEEEEEEEH
EAVSEALVFASKAGADPARVRQALMGGFASSRILEVHGERMLNRTFNPGFKISLHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHCCCCCCEEEEEEHHHHH
LALQSAKALALNLPNTATCQELFNTCAANGGSELDHSSLIQALELMANHQIA
HHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]