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The map label for this gene is hemH [H]

Identifier: 238893445

GI number: 238893445

Start: 1286935

End: 1287897

Strand: Direct

Name: hemH [H]

Synonym: KP1_1335

Alternate gene names: 238893445

Gene position: 1286935-1287897 (Clockwise)

Preceding gene: 238893444

Following gene: 238893446

Centisome position: 24.52

GC content: 60.44

Gene sequence:

>963_bases
ATGCATCAGACGAAAACAGGTATCTTGCTGGCCAATTTAGGCACTCCCGATGCGCCCACCCCCGGGGCGGTGAAGCGCTA
TCTGCGACAATTCCTCAGCGACAAACGGGTGGTGGATACGTCTCGTCTGCTATGGTGGCCGCTGCTGCGCGGCGTCATAC
TGCCGATTCGCTCCCCGCGTGTGGCGAAGCTCTATCAGTCCGTGTGGATGGAAGAGGGATCGCCGCTGATGGTGTATAGT
CGTCGCCAGCAGCAGGCGCTGGCTGCCAGGCTGCCGGATACCCCGGTGGCGCTGGGCATGAGCTATGGTTCACCGTCACT
GGCCAGCGCGGTGGATGACTTACTGGCGCAGGGGGTGGAGCACATCGTGGTGCTGCCGCTGTATCCGCAATATTCCTGCT
CGACGGTGGCCGCCGTCTGGGACGAACTGGCGCGGATTCTGGCGAAAAAGCGCGCCATTCCGGGTATCTCGTTTATTCGC
GACTATGCCGAACATCCGGACTATATCCATGCGCTGGCGGCCAGCGTGCGCGCTTCCTTCGCTGTCCATGGGGAACCGGA
TCTGCTGCTGCTCTCCTATCATGGGATCCCGCAGCGCTATGCCAACCAGGGCGATGATTATCCTCAGCGCTGTCGCGATA
CGACGCGGGAACTGGTTTCCGCGCTGGGGCTGCCGCCGGAGCGGGTGATGATGACTTTCCAGTCGCGCTTTGGCCGGGAA
CCCTGGCTGACGCCGTACACCGATGAAACGCTAAAGATGCTCGGCGAGAAAGGGACGAAGCATGTTCAGGTGCTGTGCCC
GGGGTTTGCCGCCGACTGTCTCGAAACGCTGGAAGAAATCGCCGTCCAGAACCGGGAAATATTCCTCGAAGCGGGCGGCA
AGCAATATGAATATATTCCGGCGCTTAATGCGGACGCAGCGCATATTGAGATGATGGTCAATCTGACGGCGCCTTATCGC
TGA

Upstream 100 bases:

>100_bases
GGATGAGAACTCCTCTCATTTCTACCTTTTGCTATGATTGGTTCCGTTTAGCGCCATTTCAGCTACAATTGGCTGCGATT
CAAATGGTTAAGAGGCGGTA

Downstream 100 bases:

>100_bases
TCGCGCGCAGGGCGGGGAATATGCTACTATTTCCCGCTTGTTCCCTGTTATTTAAGCGCCACTATGAAATTTCCCGGTAA
ACGCAAATCTAAACACTATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPRVAKLYQSVWMEEGSPLMVYS
RRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVEHIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIR
DYAEHPDYIHALAASVRASFAVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTKHVQVLCPGFAADCLETLEEIAVQNREIFLEAGGKQYEYIPALNADAAHIEMMVNLTAPYR

Sequences:

>Translated_320_residues
MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPRVAKLYQSVWMEEGSPLMVYS
RRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVEHIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIR
DYAEHPDYIHALAASVRASFAVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTKHVQVLCPGFAADCLETLEEIAVQNREIFLEAGGKQYEYIPALNADAAHIEMMVNLTAPYR
>Mature_320_residues
MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPRVAKLYQSVWMEEGSPLMVYS
RRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVEHIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIR
DYAEHPDYIHALAASVRASFAVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTKHVQVLCPGFAADCLETLEEIAVQNREIFLEAGGKQYEYIPALNADAAHIEMMVNLTAPYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=326, Percent_Identity=26.9938650306748, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=85, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6324750, Length=331, Percent_Identity=26.2839879154079, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=25.6024096385542, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=26.7924528301887, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35774; Mature: 35774

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPR
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCH
VAKLYQSVWMEEGSPLMVYSRRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVE
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHH
HIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIRDYAEHPDYIHALAASVRASF
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHE
AVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGRE
EECCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKMLGEKGTKHVQVLCPGFAADCLETLEEIAVQNREIFLEAGGKQYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNADAAHIEMMVNLTAPYR
CCCCCHHEEEEEEEECCCCC
>Mature Secondary Structure
MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPR
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCH
VAKLYQSVWMEEGSPLMVYSRRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVE
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHH
HIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIRDYAEHPDYIHALAASVRASF
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHE
AVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGRE
EECCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKMLGEKGTKHVQVLCPGFAADCLETLEEIAVQNREIFLEAGGKQYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNADAAHIEMMVNLTAPYR
CCCCCHHEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA