| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is lon [H]
Identifier: 238893388
GI number: 238893388
Start: 1227198
End: 1229660
Strand: Direct
Name: lon [H]
Synonym: KP1_1272
Alternate gene names: 238893388
Gene position: 1227198-1229660 (Clockwise)
Preceding gene: 238893387
Following gene: 238893389
Centisome position: 23.38
GC content: 55.46
Gene sequence:
>2463_bases TTGAATGTGTGGAATACATCCCCATATACTGGATTACATATTAACGACGATGCAGTGGAGTGTGGCGTCGTCGGCTACCT GGCGGACTTTAAACTAAGAGAGAGCTCTATGAATCCTGAGCGTTCTGAACGCATTGAAATCCCCGTATTGCCATTGCGCG ATGTGGTGGTTTATCCGCACATGGTCATACCCCTGTTCGTAGGGCGGGAAAAATCTATCCGTTGCCTCGAAGCGGCCATG GACCATGATAAAAAAATCATGCTGGTTGCGCAGAAAGAAGCGTCGACGGATGAGCCGGGTGTAAACGATCTTTTCACCGT TGGAACCGTGGCGTCTATTTTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTGGTCGAAGGGCTGCAGCGTG CTCGCATTTCTGCGCTGTCTGATAATGGCGAGCATTTCTCGGCGAAAGCGGAGTATCTCGACTCGCCGGCGATTGACGAA CGCGAGCAGGAAGTGCTGGTTCGCACCGCTATCAGCCAGTTTGAAGGCTATATCAAGCTGAACAAGAAGATCCCACCGGA AGTGCTGACGTCGCTGAACAGCATCGACGATCCGGCGCGCCTGGCGGATACCATCGCGGCGCACATGCCGCTGAAGCTGG CTGACAAGCAGTCTGTGCTTGAGATGTCCGACGTTAACGAACGTCTGGAATATCTGATGGCGATGATGGAATCGGAAATC GATCTGCTGCAGGTTGAGAAGCGCATTCGCAACCGCGTCAAAAAGCAGATGGAGAAATCTCAGCGCGAGTACTATCTGAA CGAGCAAATGAAAGCGATTCAGAAAGAACTCGGCGAGATGGACGACGCCCCGGACGAAAACGAAGCGCTGAAGCGTAAGA TCGACGCGGCGAAAATGCCGAAAGAGGCGAAAGAAAAAACCGAAGCGGAACTGCAGAAGCTGAAGATGATGTCGCCGATG TCAGCGGAAGCGACCGTCGTGCGTGGCTACATCGACTGGATGGTGCAGGTGCCGTGGAATGCGCGCAGTAAGGTCAAAAA AGACCTGCGTCAGGCCCAGGAGATCCTCGATACCGATCACTATGGCCTGGAGCGCGTGAAGGATCGCATCCTTGAATATC TCGCGGTGCAGAGCCGGGTGAACAAAATCAAGGGGCCAATCCTTTGTCTGGTGGGACCGCCGGGGGTAGGTAAAACCTCG CTGGGTCAATCCATCGCCAAAGCGACCGGACGGAAATACGTTCGTATGGCGCTTGGCGGCGTGCGCGATGAAGCGGAAAT CCGCGGTCATCGTCGGACCTACATTGGCTCGATGCCGGGCAAACTGATCCAGAAAATGGCGAAAGTGGGGGTCAAAAACC CGCTGTTCCTGTTGGACGAGATCGACAAAATGTCTTCCGACATGCGCGGCGACCCGGCTTCCGCGTTGCTTGAGGTGCTG GATCCGGAACAGAACGTGGCCTTTAACGACCACTATCTGGAAGTGGATTACGATCTCAGCGACGTGATGTTCGTGGCGAC TTCCAACTCCATGAACATTCCGGCGCCGCTGCTGGACCGTATGGAAGTGATTCGTCTCTCCGGCTATACCGAAGATGAAA AACTGAACATCGCCAAACGTCATCTGCTGCCGAAGCAGATCGAACGTAACGCGCTGAAGAAAGGCGAGTTGACCGTCGAC GATAGCGCCATTATCGGCATTATTCGTTACTACACGCGGGAAGCGGGGGTACGTAGCCTGGAGCGTGAAATCTCCAAGCT GTGCCGCAAGGCCGTTAAGCAACTGCTGCTGGATAAATCGCTGAAACACATCGAAATTAACGGTGAGAATCTGCATGATT ATCTCGGCGTACAGCGCTTCGACTATGGCCGCGCCGATAGTGAGAACCGCGTCGGTCAGGTGACCGGTCTGGCGTGGACG GAAGTGGGCGGCGATCTGCTGACCATCGAAACCGCCTGCGTGCCGGGCAAAGGCAAGCTGACCTACACCGGCTCGCTGGG CGAGGTGATGCAGGAGTCGATTCAGGCTGCGCTGACGGTGGTACGTTCGCGGGCTGACAAGCTGGGCATTAACGCCGACT TCTACGAGAAGCGTGACATTCACGTGCACGTGCCGGAAGGGGCGACGCCTAAGGATGGTCCGAGCGCGGGTATTGCCATG TGCACGGCGCTGGTATCCTGCCTGACCGGTAACCCGGTACGCGCTGATGTGGCGATGACCGGTGAAATCACTCTGCGTGG TCAGGTGCTGCCGATCGGCGGTCTGAAGGAAAAACTGCTGGCGGCGCATCGCGGCGGCATTAAGACTGTTCTGATTCCTG ATGAGAACAAACGCGACCTTGAAGAAATTCCGGATAACGTTATCGCCGATTTGGATATCCATCCGGTGAAACGAATCGAG GAAGTTCTGACACTTGCGCTGCAGAACGAACCGTTCGGCATGCAGGTTGTGACCGCGAAATAG
Upstream 100 bases:
>100_bases AGCTCAGCAGGCATCTGGTGAATAATTAACCATTTCACTCAAGCAGTTAACAAAAAGGGGGGATTTTATCTCCCCTTTTA TTTTTCCTGCATTCCCGCCG
Downstream 100 bases:
>100_bases TGATTCTGCGCAAATTGCGCTAATAAAAATAGGGCTGGTAAGTCATTTCGGACTTGCCAGCCTTTTTTTGTGTAGCTAAC TTAGATCGCTGGCAGGGGGG
Product: DNA-binding ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 820; Mature: 820
Protein sequence:
>820_residues MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE EVLTLALQNEPFGMQVVTAK
Sequences:
>Translated_820_residues MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE EVLTLALQNEPFGMQVVTAK >Mature_820_residues MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE EVLTLALQNEPFGMQVVTAK
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=46.7140319715808, Blast_Score=513, Evalue=1e-145, Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=41.6267942583732, Blast_Score=513, Evalue=1e-145, Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=98.469387755102, Blast_Score=1571, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=40.8748114630468, Blast_Score=498, Evalue=1e-141, Organism=Caenorhabditis elegans, GI17556486, Length=794, Percent_Identity=33.2493702770781, Blast_Score=429, Evalue=1e-120, Organism=Saccharomyces cerevisiae, GI6319449, Length=863, Percent_Identity=36.3847045191193, Blast_Score=488, Evalue=1e-138, Organism=Drosophila melanogaster, GI221513036, Length=628, Percent_Identity=44.5859872611465, Blast_Score=533, Evalue=1e-151, Organism=Drosophila melanogaster, GI24666867, Length=628, Percent_Identity=44.5859872611465, Blast_Score=533, Evalue=1e-151,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 91458; Mature: 91458
Theoretical pI: Translated: 5.96; Mature: 5.96
Prosite motif: PS01046 LON_SER ; PS00178 AA_TRNA_LIGASE_I
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 3.8 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 3.8 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPH CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCEEECCCCCHHHHHHCCH MVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLP HHHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC DGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKL CHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEE NKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCH DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMP HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC KEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDH HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCC YGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGG CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC VRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL CCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKR CCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH HLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKS HCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC LKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKL CCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEECEEHHHCCCCEEEEEEEECCCCCCE TYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDL HHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHH EEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK HHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECC >Mature Secondary Structure MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPH CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCEEECCCCCHHHHHHCCH MVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLP HHHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC DGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKL CHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEE NKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCH DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMP HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC KEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDH HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCC YGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGG CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC VRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL CCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKR CCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH HLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKS HCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC LKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKL CCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEECEEHHHCCCCEEEEEEEECCCCCCE TYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDL HHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHH EEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK HHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA