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The map label for this gene is proY [H]

Identifier: 238893326

GI number: 238893326

Start: 1168601

End: 1169965

Strand: Direct

Name: proY [H]

Synonym: KP1_1204

Alternate gene names: 238893326

Gene position: 1168601-1169965 (Clockwise)

Preceding gene: 238893325

Following gene: 238893327

Centisome position: 22.27

GC content: 58.83

Gene sequence:

>1365_bases
ATGGAAAGTAGTAACAAGCTTAAGCGCGGGCTAAGCACCCGGCACATTCGCTTTATGGCCCTGGGTTCCGCCATCGGCAC
CGGGCTTTTTTACGGCTCGGCCGACGCCATTAAAATGGCCGGACCCAGCGTACTGTTGGCCTACATTATCGGCGGCGTCG
CGGCATATATCATTATGCGGGCGCTCGGTGAGATGTCGGTGCATAACCCTGCCGCCAGCTCATTCTCCCGCTATGCCCAG
GAAAACCTCGGCGGACTGGCGGGCTATATCACCGGCTGGACCTACTGCTTTGAAATCCTGATCGTCGCCATCGCCGACGT
TACCGCCTTCGGCATCTACATGGGCGTCTGGTTCCCGACGGTGCCGCACTGGATCTGGGTGCTCAGCGTGGTGCTGATCA
TCTGCGCCGTCAACCTGATGAGCGTCAAGGTGTTTGGCGAGCTGGAGTTCTGGTTCTCGTTCTTCAAAGTGGCCACCATT
ATCATCATGATCCTCGCCGGGTTCGGCATCATTATCTGGGGGATCGGCAACGGCGGCCAGCCGACGGGGATTCATAACCT
GTGGAGCAACGGCGGCTTCTTCAGCAACGGCTGGCTGGGAATGGTGATGTCGCTGCAGATGGTGATGTTCGCTTACGGCG
GCATCGAAATCATCGGCATTACCGCCGGTGAGGCGAAGGACCCGGAGAAATCCATTCCGCGCGCCATCAACTCGGTGCCG
ATGCGCATTCTGGTGTTCTACGTCGGCACGCTGTTCGTCATTATGTCCATCTACCCGTGGAATCAGGTGGGAACCGACGG
CAGCCCCTTCGTCCTGACCTTCCAGCATCTGGGCATTACCTTCGCGGCCAGTATTCTTAACTTCGTGGTCCTGACGGCTT
CGCTGTCGGCGATTAACTCCGACGTGTTCGGCGTGGGCCGTATGCTGCACGGCATGGCTGAGCAGGGCAGCGCGCCGAAG
GTGTTCGCTAAAACGTCGCGTCGCGGTATTCCGTGGGTGACGGTGATGGTGATGACCATTGCGCTGCTGTTTGCGGTATA
CCTAAATTACATCATGCCGGAGAACGTTTTCCTGGTGATCGCCTCCCTGGCCACCTTCGCCACGGTGTGGGTGTGGATTA
TGATCCTGCTGTCACAGATAGCCTTCCGCCGCCGTCTGTCGCCCGAAGAGGTTAAGGCGCTGAAATTCAAAGTCCCTGGC
GGGGTGGTGACCACGGTGATCGGCCTGCTGTTCCTGGCCTTTATTATCGCCCTTATCGGCTATCATCCGGACACCCGCAT
CTCGCTGTACGTCGGTATGGCGTGGATTGCGCTGTTGCTGCTCGGCTGGGTCTTTAAGACCCGCCGTGAGCGCCGCCTGG
CGTAG

Upstream 100 bases:

>100_bases
CCAGCGCGCATTAACCGGCGGTGAGGACAAGCGTTTAACCACGGGACTTCGGGTTCCGTGGTTTTTTATTTTTTGTGTTA
AACGGCATTGAAAAACCACG

Downstream 100 bases:

>100_bases
GCTCAGTAATCGACATCGCCCCGGTCAGCATCGCGCGGCCGGGGCGGCTTGCGGTCCCGCGTCCTCCCCCGTTATCCTCC
CCCAAAAAGTTCTGAGATGA

Product: putative proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MESSNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATI
IIMILAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPG
GVVTTVIGLLFLAFIIALIGYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLA

Sequences:

>Translated_454_residues
MESSNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATI
IIMILAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPG
GVVTTVIGLLFLAFIIALIGYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLA
>Mature_454_residues
MESSNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATI
IIMILAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPG
GVVTTVIGLLFLAFIIALIGYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=26.271186440678, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI181337167, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=21.6783216783217, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614005, Length=430, Percent_Identity=21.6279069767442, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI258614003, Length=430, Percent_Identity=21.6279069767442, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=94.273127753304, Blast_Score=803, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=456, Percent_Identity=45.6140350877193, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=44, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI48994972, Length=434, Percent_Identity=44.7004608294931, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=40.7488986784141, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=38.5, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI87081708, Length=459, Percent_Identity=36.3834422657952, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1788480, Length=406, Percent_Identity=37.192118226601, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=33.8747099767981, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87081869, Length=176, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082023, Length=280, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=23.3644859813084, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=372, Percent_Identity=24.4623655913978, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=401, Percent_Identity=23.4413965087282, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=466, Percent_Identity=33.0472103004292, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320772, Length=400, Percent_Identity=34, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=32.2072072072072, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=445, Percent_Identity=30.7865168539326, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=418, Percent_Identity=28.7081339712919, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=447, Percent_Identity=30.8724832214765, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=457, Percent_Identity=27.3522975929978, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=418, Percent_Identity=30.8612440191388, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=32.3308270676692, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=431, Percent_Identity=27.1461716937355, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=27.2277227722772, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=27.0471464019851, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=26.056338028169, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=27.3182957393484, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=25.1101321585903, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=25.3768844221106, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=431, Percent_Identity=25.2900232018561, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=24.3564356435644, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=21.7917675544794, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666159, Length=413, Percent_Identity=21.7917675544794, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077963, Length=333, Percent_Identity=25.5255255255255, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49766; Mature: 49766

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPT
HHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPDTRISLYVGMAWIALLLLGWVFKTRRERRLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MESSNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPT
HHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPDTRISLYVGMAWIALLLLGWVFKTRRERRLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]