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The map label for this gene is mmuM [H]

Identifier: 238893292

GI number: 238893292

Start: 1134731

End: 1135663

Strand: Direct

Name: mmuM [H]

Synonym: KP1_1168

Alternate gene names: 238893292

Gene position: 1134731-1135663 (Clockwise)

Preceding gene: 238893291

Following gene: 238893293

Centisome position: 21.62

GC content: 68.06

Gene sequence:

>933_bases
ATGTCGCAGACTAATCCGTTTACCGCCCTGCTTGCCGCCCAGCCTTTCGTGCTGCTGGACGGCGCCATGGCCACCGAGCT
GGAGGCCCGCGGCTGCGATCTGGCCGACAGCCTGTGGTCGGCGAAAGTGCTGCTGGAGAACCCGCAGCTGATCCGCGATG
TGCATCTCGACTACTTTCGCGCCGGGGCGCAGGTGGCGATCACCGCCAGCTATCAGGCCACTCCGGCGGGCTTTGCCGCG
CGCGGGCTGGATGAGGCGCAGTCCCGGGCGCTAATCGGCAAAAGCGTCGAGCTGGCGCGCAAAGCGCGCGAGGCGTACCT
CGCCGAGAACCCGCAGGCCGGTACGCTGCTGGTGGCCGGTTCGGTGGGGCCGTATGGCGCGTTTCTCGCCGACGGCTCGG
AGTATCGCGGCGATTATCAGCGCAGCGCGGCAGAGTTCCAGGCCTTCCACCGCCCGCGCGTCGAAGCGCTGCTGGATGCC
GGCGCCGACCTGCTGGCCTGTGAAACCCTGCCGTCATTCGCTGAGATCCAGGCCCTGGCGGCCCTGCTGCAGGAGTATCC
CCGCGCCCGCGCCTGGTACTCCTTCACGCTGCGCGACGCCGAACATCTCAGCGACGGCACGCCGCTGCGCGAGGTGATGG
CCGCCCTGGCGGATAACCCGCAGGTGGTGGCGGTGGGGATCAACTGTATCGCCCTGGAAAATACGCCCGCGGCGCTGGCG
CATCTGCACAGCCTGACGGCCCTGCCGCTGGTGGTCTATCCTAACTCCGGCGAACATTATGATGCGGTGAGCAAGACCTG
GCACCATCATGGCGAAGCCTGCGCCAGCCTGGCGGATTATCTGCCGCAGTGGCTGGCCGCCGGGGCGAAGCTGATCGGCG
GCTGCTGCCGCACCACGCCGAAGGACATCGCCGCGCTTAACGCGAAGCGCTAA

Upstream 100 bases:

>100_bases
AGCCAGAGAATTGCGCTGTGGTGCGGGATCCCCTTTGTGGCCCTGTGCTATGGTGCCTGGTATCTTACTCGTTCACGGAA
TATGACTCAGGAGCCCCAAC

Downstream 100 bases:

>100_bases
ATTTTTGCCGGGTGGCGCTGCGCTTACCCGGCCTACATATTGCGCGAACCGGATGCTGGGTAAGGCGTAGCCGCCGCCCG
GCGCCAACCATCTGCCACTA

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSQTNPFTALLAAQPFVLLDGAMATELEARGCDLADSLWSAKVLLENPQLIRDVHLDYFRAGAQVAITASYQATPAGFAA
RGLDEAQSRALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAFLADGSEYRGDYQRSAAEFQAFHRPRVEALLDA
GADLLACETLPSFAEIQALAALLQEYPRARAWYSFTLRDAEHLSDGTPLREVMAALADNPQVVAVGINCIALENTPAALA
HLHSLTALPLVVYPNSGEHYDAVSKTWHHHGEACASLADYLPQWLAAGAKLIGGCCRTTPKDIAALNAKR

Sequences:

>Translated_310_residues
MSQTNPFTALLAAQPFVLLDGAMATELEARGCDLADSLWSAKVLLENPQLIRDVHLDYFRAGAQVAITASYQATPAGFAA
RGLDEAQSRALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAFLADGSEYRGDYQRSAAEFQAFHRPRVEALLDA
GADLLACETLPSFAEIQALAALLQEYPRARAWYSFTLRDAEHLSDGTPLREVMAALADNPQVVAVGINCIALENTPAALA
HLHSLTALPLVVYPNSGEHYDAVSKTWHHHGEACASLADYLPQWLAAGAKLIGGCCRTTPKDIAALNAKR
>Mature_309_residues
SQTNPFTALLAAQPFVLLDGAMATELEARGCDLADSLWSAKVLLENPQLIRDVHLDYFRAGAQVAITASYQATPAGFAAR
GLDEAQSRALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAFLADGSEYRGDYQRSAAEFQAFHRPRVEALLDAG
ADLLACETLPSFAEIQALAALLQEYPRARAWYSFTLRDAEHLSDGTPLREVMAALADNPQVVAVGINCIALENTPAALAH
LHSLTALPLVVYPNSGEHYDAVSKTWHHHGEACASLADYLPQWLAAGAKLIGGCCRTTPKDIAALNAKR

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=311, Percent_Identity=26.0450160771704, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786456, Length=309, Percent_Identity=85.1132686084142, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17569783, Length=259, Percent_Identity=27.7992277992278, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324982, Length=332, Percent_Identity=30.421686746988, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322966, Length=325, Percent_Identity=28.9230769230769, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323983, Length=99, Percent_Identity=41.4141414141414, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129603, Length=307, Percent_Identity=39.0879478827362, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24585077, Length=314, Percent_Identity=35.031847133758, Blast_Score=194, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 33155; Mature: 33024

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTNPFTALLAAQPFVLLDGAMATELEARGCDLADSLWSAKVLLENPQLIRDVHLDYFR
CCCCCCHHHHHHCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
AGAQVAITASYQATPAGFAARGLDEAQSRALIGKSVELARKAREAYLAENPQAGTLLVAG
CCCEEEEEEECCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SVGPYGAFLADGSEYRGDYQRSAAEFQAFHRPRVEALLDAGADLLACETLPSFAEIQALA
CCCCCHHHCCCCHHHCCHHHHHHHHHHHHHCHHHHHHHHCCCCEEEHHCCCCHHHHHHHH
ALLQEYPRARAWYSFTLRDAEHLSDGTPLREVMAALADNPQVVAVGINCIALENTPAALA
HHHHHCCCCHHEEEEEECCHHHCCCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHH
HLHSLTALPLVVYPNSGEHYDAVSKTWHHHGEACASLADYLPQWLAAGAKLIGGCCRTTP
HHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KDIAALNAKR
HHHHHCCCCC
>Mature Secondary Structure 
SQTNPFTALLAAQPFVLLDGAMATELEARGCDLADSLWSAKVLLENPQLIRDVHLDYFR
CCCCCHHHHHHCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
AGAQVAITASYQATPAGFAARGLDEAQSRALIGKSVELARKAREAYLAENPQAGTLLVAG
CCCEEEEEEECCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SVGPYGAFLADGSEYRGDYQRSAAEFQAFHRPRVEALLDAGADLLACETLPSFAEIQALA
CCCCCHHHCCCCHHHCCHHHHHHHHHHHHHCHHHHHHHHCCCCEEEHHCCCCHHHHHHHH
ALLQEYPRARAWYSFTLRDAEHLSDGTPLREVMAALADNPQVVAVGINCIALENTPAALA
HHHHHCCCCHHEEEEEECCHHHCCCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHH
HLHSLTALPLVVYPNSGEHYDAVSKTWHHHGEACASLADYLPQWLAAGAKLIGGCCRTTP
HHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KDIAALNAKR
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]