Click here to switch to the map view.

The map label for this gene is ykfD [H]

Identifier: 238893291

GI number: 238893291

Start: 1133335

End: 1134744

Strand: Direct

Name: ykfD [H]

Synonym: KP1_1167

Alternate gene names: 238893291

Gene position: 1133335-1134744 (Clockwise)

Preceding gene: 238893290

Following gene: 238893292

Centisome position: 21.59

GC content: 60.92

Gene sequence:

>1410_bases
ATGCAAAGCACAACACAACAACAAGGTGGGCAGCTGAAGCGCACCATGAAAACGCGCCATCTGATCATGCTGTCGCTCGG
CGGCGTGATTGGCACCGGCTTATTCTTTAATACCGGCTATATCATCTCCACCACCGGCGCGGCCGGGACGCTGCTGGCGT
ATCTGATTGGCGCCCTGGTGGTCTGGCTGGTGATGCAGTGCCTTGGCGAACTGTCGGTGGCGATGCCAGAGACCGGCGCC
TTCCACGTTTACGCGGCGCGCTATCTTGGCCCGGCGACGGGCTATACCGTGGCGTGGCTCTACTGGCTAACGTGGACGGT
GGCGCTGGGGTCGAGCTTCACCGCGGCGGGATTCTGCATGCAGTACTGGTTCCCGCAGGTGCCGGTCTGGATCTGGTGCG
TGGTGTTCTGCACAGTGATCTTCGGCCTTAACATCATTTCGACGCGCTTCTTCGCCGAAGGCGAGTTCTGGTTCTCGCTG
GTGAAAGTGGTCACCATCGTCGCGTTTATTATTCTCGGCGGCGCGGCCATTTTCGGCATCATTCCGATGCAGGATGGCTC
GCCGGCGCCGGGCCTGCGCAATATCACCGCCGAAGGTTGGTTCCCGCACGGCGGCCTGCCGATCCTGATGACCATGGTGG
CGGTGAACTTCGCCTTCTCCGGGACGGAGCTTATCGGCATTGCCGCCGGAGAGACGGAAAACCCGCATAAGGTTATTCCG
GTTGCCATCCGCACCACCATCGCCCGGCTGATTATTTTCTTTATCGGCACCGTGTTTGTGCTGGCGGCGCTGATCCCGAT
GCAGCAGGCGGGAGTGGAGAAAAGCCCCTTCGTGCTGGTGTTTGAGAAGGTGGGCATCCCTTATGCGGCGGACATGTTCA
ACTTCGTGATCCTGACGGCGATCCTGTCGGCGGCTAACTCCGGCCTGTACGCTTCCGGGCGGATGCTGTGGTCGCTGTCG
AACGAGAAGACGCTGCCGGCCTGCTTTGCCAAAGTCAATAAACGGGGCGTGCCGGTGACCGCCCTGTCGGTGAGTATGCT
GGGCGGCGTGCTGGCGCTGTTCTCCAGCGTGGTGGCGCCAGATACGGTGTTTGTCGCGCTGTCGGCGATCTCCGGTTTTG
CGGTGGTGGCGGTGTGGTTGAGCATCTGCGCCTCGCACTTTATGTTCCGCCGCCGCCATCTGCAGCAGGGTAAGGCTCTG
AGCGATCTGCAGTATCGCGCTCCCTGGTATCCGGTAGTGCCCGTTCTGGGCTTTGTGCTGTGCCTGGTGGCCTGCGTGGG
CCTCGCTTTTGACCCGAGCCAGAGAATTGCGCTGTGGTGCGGGATCCCCTTTGTGGCCCTGTGCTATGGTGCCTGGTATC
TTACTCGTTCACGGAATATGACTCAGGAGCCCCAACATGTCGCAGACTAA

Upstream 100 bases:

>100_bases
AGCGGCGGCACGGTATAACACTTCTTCTTTTGGATGTTTAGATGTCTATACGTTTATACGCAGCATGACCCGGGCAAGCG
GGCTGGCGTGAGAAAATAAA

Downstream 100 bases:

>100_bases
TCCGTTTACCGCCCTGCTTGCCGCCCAGCCTTTCGTGCTGCTGGACGGCGCCATGGCCACCGAGCTGGAGGCCCGCGGCT
GCGATCTGGCCGACAGCCTG

Product: S-methylmethionine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MQSTTQQQGGQLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALVVWLVMQCLGELSVAMPETGA
FHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCMQYWFPQVPVWIWCVVFCTVIFGLNIISTRFFAEGEFWFSL
VKVVTIVAFIILGGAAIFGIIPMQDGSPAPGLRNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPHKVIP
VAIRTTIARLIIFFIGTVFVLAALIPMQQAGVEKSPFVLVFEKVGIPYAADMFNFVILTAILSAANSGLYASGRMLWSLS
NEKTLPACFAKVNKRGVPVTALSVSMLGGVLALFSSVVAPDTVFVALSAISGFAVVAVWLSICASHFMFRRRHLQQGKAL
SDLQYRAPWYPVVPVLGFVLCLVACVGLAFDPSQRIALWCGIPFVALCYGAWYLTRSRNMTQEPQHVAD

Sequences:

>Translated_469_residues
MQSTTQQQGGQLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALVVWLVMQCLGELSVAMPETGA
FHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCMQYWFPQVPVWIWCVVFCTVIFGLNIISTRFFAEGEFWFSL
VKVVTIVAFIILGGAAIFGIIPMQDGSPAPGLRNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPHKVIP
VAIRTTIARLIIFFIGTVFVLAALIPMQQAGVEKSPFVLVFEKVGIPYAADMFNFVILTAILSAANSGLYASGRMLWSLS
NEKTLPACFAKVNKRGVPVTALSVSMLGGVLALFSSVVAPDTVFVALSAISGFAVVAVWLSICASHFMFRRRHLQQGKAL
SDLQYRAPWYPVVPVLGFVLCLVACVGLAFDPSQRIALWCGIPFVALCYGAWYLTRSRNMTQEPQHVAD
>Mature_469_residues
MQSTTQQQGGQLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALVVWLVMQCLGELSVAMPETGA
FHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCMQYWFPQVPVWIWCVVFCTVIFGLNIISTRFFAEGEFWFSL
VKVVTIVAFIILGGAAIFGIIPMQDGSPAPGLRNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPHKVIP
VAIRTTIARLIIFFIGTVFVLAALIPMQQAGVEKSPFVLVFEKVGIPYAADMFNFVILTAILSAANSGLYASGRMLWSLS
NEKTLPACFAKVNKRGVPVTALSVSMLGGVLALFSSVVAPDTVFVALSAISGFAVVAVWLSICASHFMFRRRHLQQGKAL
SDLQYRAPWYPVVPVLGFVLCLVACVGLAFDPSQRIALWCGIPFVALCYGAWYLTRSRNMTQEPQHVAD

Specific function: Transporter for the intake of S-methylmethionine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=376, Percent_Identity=22.8723404255319, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI258614005, Length=391, Percent_Identity=22.7621483375959, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=391, Percent_Identity=22.7621483375959, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=92.5373134328358, Blast_Score=880, Evalue=0.0,
Organism=Escherichia coli, GI1788480, Length=480, Percent_Identity=38.125, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1786302, Length=466, Percent_Identity=36.2660944206009, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI48994972, Length=443, Percent_Identity=36.7945823927765, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=35.3846153846154, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1786789, Length=428, Percent_Identity=35.2803738317757, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87081915, Length=450, Percent_Identity=34, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789017, Length=452, Percent_Identity=33.8495575221239, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1790653, Length=472, Percent_Identity=32.2033898305085, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI2367353, Length=410, Percent_Identity=25.1219512195122, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081869, Length=399, Percent_Identity=24.812030075188, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082250, Length=351, Percent_Identity=23.3618233618234, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=444, Percent_Identity=20.9459459459459, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=427, Percent_Identity=32.7868852459016, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6320717, Length=451, Percent_Identity=31.9290465631929, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=427, Percent_Identity=31.615925058548, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324553, Length=406, Percent_Identity=33.9901477832512, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6319824, Length=452, Percent_Identity=30.0884955752212, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6324059, Length=427, Percent_Identity=32.7868852459016, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324990, Length=480, Percent_Identity=30.625, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=30.045871559633, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321629, Length=431, Percent_Identity=29.2343387470998, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=411, Percent_Identity=29.683698296837, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319542, Length=440, Percent_Identity=28.6363636363636, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=417, Percent_Identity=29.9760191846523, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=424, Percent_Identity=27.3584905660377, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=412, Percent_Identity=29.8543689320388, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322967, Length=412, Percent_Identity=29.126213592233, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=412, Percent_Identity=30.3398058252427, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=23.3409610983982, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=489, Percent_Identity=23.1083844580777, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=22.0338983050847, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50809; Mature: 50809

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTTQQQGGQLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALV
CCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCHHHHHHHHHHHHHH
VWLVMQCLGELSVAMPETGAFHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCM
HHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
QYWFPQVPVWIWCVVFCTVIFGLNIISTRFFAEGEFWFSLVKVVTIVAFIILGGAAIFGI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
IPMQDGSPAPGLRNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPHKVIP
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEH
VAIRTTIARLIIFFIGTVFVLAALIPMQQAGVEKSPFVLVFEKVGIPYAADMFNFVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ILSAANSGLYASGRMLWSLSNEKTLPACFAKVNKRGVPVTALSVSMLGGVLALFSSVVAP
HHHHCCCCCEECCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
DTVFVALSAISGFAVVAVWLSICASHFMFRRRHLQQGKALSDLQYRAPWYPVVPVLGFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCCCHHHHHHHHH
CLVACVGLAFDPSQRIALWCGIPFVALCYGAWYLTRSRNMTQEPQHVAD
HHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure
MQSTTQQQGGQLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALV
CCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCHHHHHHHHHHHHHH
VWLVMQCLGELSVAMPETGAFHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCM
HHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
QYWFPQVPVWIWCVVFCTVIFGLNIISTRFFAEGEFWFSLVKVVTIVAFIILGGAAIFGI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
IPMQDGSPAPGLRNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPHKVIP
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEH
VAIRTTIARLIIFFIGTVFVLAALIPMQQAGVEKSPFVLVFEKVGIPYAADMFNFVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ILSAANSGLYASGRMLWSLSNEKTLPACFAKVNKRGVPVTALSVSMLGGVLALFSSVVAP
HHHHCCCCCEECCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
DTVFVALSAISGFAVVAVWLSICASHFMFRRRHLQQGKALSDLQYRAPWYPVVPVLGFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCCCHHHHHHHHH
CLVACVGLAFDPSQRIALWCGIPFVALCYGAWYLTRSRNMTQEPQHVAD
HHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684 [H]