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The map label for this gene is nadC [H]

Identifier: 238893088

GI number: 238893088

Start: 914917

End: 915810

Strand: Reverse

Name: nadC [H]

Synonym: KP1_0932

Alternate gene names: 238893088

Gene position: 915810-914917 (Counterclockwise)

Preceding gene: 238893091

Following gene: 238893087

Centisome position: 17.45

GC content: 58.84

Gene sequence:

>894_bases
ATGTCGCCTCGTCGTTACAACCCCGACCGCCGCCGTGACGTGCTGCTGGAACGTATTAATCTCGATATTACCGATGCTGT
CGCACACTCCCTGCGGGAAGATCTGGGCGGCGAAGTCGACGCCAACAACGATATTAGCGCGCAATTATTGCCGCAGGATG
CACGCTCCCATGCGGTGGTCATTACTCGTGAAGATGGCGTCTTCTGTGGCAAACGCTGGGTGGAAGAGGTCTTTATTCAG
CTCGCCGGTGACGATGTGAATATCACCTGGCACGTGGCCGACGGCGATGCGGTCAAAGCCGACCAGCCGCTGTTCGAATT
GGAAGGCCCGTCGCGTATTCTGCTCACCGGCGAACGCACGGCGCTGAACTTTGTGCAAACCCTCTCCGGCGTCGCCAGCG
TCGTCCGTCGCTATGTCGACCTACTCGCCGGCACCAAAACCCAACTGCTGGATACGCGCAAAACGCTGCCAGGGCTGCGT
ACCGCGCTGAAATACGCGGTACTCTGCGGCGGAGGCGCCAACCATCGACTGGGCCTGTTCGACGCGTTCCTGATTAAAGA
AAACCACATTATCGCCTCCGGATCGATCCGTCAGGCAGTGGAAAAGGCGTTCTGGCTGCATCCTGATGTGCCGGTGGAAG
TGGAAGTGGAAACCCTGGATGAACTGGAGCAGGCGTTAAAAGCCGGGGCCGATATCATTATGCTCGATAACTTCACCACC
GACCTGATGCGCGAGGCGGTGAAAATTACCGCAGGCCAGGCGGCGCTGGAGGTCTCCGGCAACGTTACCTTTGACACCAT
CCGCGAATTCGCCGATACCGGCGTCGACTATATTTCCGTCGGCGCCCTGACCAAACATGTGCAGGCGCTCGACCTGTCGA
TGCGCTTCCGCTGA

Upstream 100 bases:

>100_bases
GCCACACGCCGGCCCAAAGGATGAAGTGTGTATGGTACTAAAACGTCGTTCAGGTTAGCATGTTTCCCACTTCTGAATCT
TATCTATCTGGAGCTTTATC

Downstream 100 bases:

>100_bases
GCAACAGGCCTTCACGCTTCCGGGCGTGAAGGCCTGAATTTGCGGCCCGCCTCGCAGTCGCCCGTGCTCACCATGAAATC
CAGATAAAAACCCTGGAACC

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSPRRYNPDRRRDVLLERINLDITDAVAHSLREDLGGEVDANNDISAQLLPQDARSHAVVITREDGVFCGKRWVEEVFIQ
LAGDDVNITWHVADGDAVKADQPLFELEGPSRILLTGERTALNFVQTLSGVASVVRRYVDLLAGTKTQLLDTRKTLPGLR
TALKYAVLCGGGANHRLGLFDAFLIKENHIIASGSIRQAVEKAFWLHPDVPVEVEVETLDELEQALKAGADIIMLDNFTT
DLMREAVKITAGQAALEVSGNVTFDTIREFADTGVDYISVGALTKHVQALDLSMRFR

Sequences:

>Translated_297_residues
MSPRRYNPDRRRDVLLERINLDITDAVAHSLREDLGGEVDANNDISAQLLPQDARSHAVVITREDGVFCGKRWVEEVFIQ
LAGDDVNITWHVADGDAVKADQPLFELEGPSRILLTGERTALNFVQTLSGVASVVRRYVDLLAGTKTQLLDTRKTLPGLR
TALKYAVLCGGGANHRLGLFDAFLIKENHIIASGSIRQAVEKAFWLHPDVPVEVEVETLDELEQALKAGADIIMLDNFTT
DLMREAVKITAGQAALEVSGNVTFDTIREFADTGVDYISVGALTKHVQALDLSMRFR
>Mature_296_residues
SPRRYNPDRRRDVLLERINLDITDAVAHSLREDLGGEVDANNDISAQLLPQDARSHAVVITREDGVFCGKRWVEEVFIQL
AGDDVNITWHVADGDAVKADQPLFELEGPSRILLTGERTALNFVQTLSGVASVVRRYVDLLAGTKTQLLDTRKTLPGLRT
ALKYAVLCGGGANHRLGLFDAFLIKENHIIASGSIRQAVEKAFWLHPDVPVEVEVETLDELEQALKAGADIIMLDNFTTD
LMREAVKITAGQAALEVSGNVTFDTIREFADTGVDYISVGALTKHVQALDLSMRFR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=260, Percent_Identity=34.2307692307692, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786299, Length=297, Percent_Identity=83.1649831649832, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=31.8897637795276, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32746; Mature: 32614

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRRYNPDRRRDVLLERINLDITDAVAHSLREDLGGEVDANNDISAQLLPQDARSHAVV
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEE
ITREDGVFCGKRWVEEVFIQLAGDDVNITWHVADGDAVKADQPLFELEGPSRILLTGERT
EECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCCEEEEECCHH
ALNFVQTLSGVASVVRRYVDLLAGTKTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHEECCCCCCCCHHH
DAFLIKENHIIASGSIRQAVEKAFWLHPDVPVEVEVETLDELEQALKAGADIIMLDNFTT
EEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCHH
DLMREAVKITAGQAALEVSGNVTFDTIREFADTGVDYISVGALTKHVQALDLSMRFR
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
SPRRYNPDRRRDVLLERINLDITDAVAHSLREDLGGEVDANNDISAQLLPQDARSHAVV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEE
ITREDGVFCGKRWVEEVFIQLAGDDVNITWHVADGDAVKADQPLFELEGPSRILLTGERT
EECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCCEEEEECCHH
ALNFVQTLSGVASVVRRYVDLLAGTKTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHEECCCCCCCCHHH
DAFLIKENHIIASGSIRQAVEKAFWLHPDVPVEVEVETLDELEQALKAGADIIMLDNFTT
EEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCHH
DLMREAVKITAGQAALEVSGNVTFDTIREFADTGVDYISVGALTKHVQALDLSMRFR
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]