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The map label for this gene is fadH [C]

Identifier: 238893052

GI number: 238893052

Start: 873448

End: 875481

Strand: Reverse

Name: fadH [C]

Synonym: KP1_0891

Alternate gene names: 238893052

Gene position: 875481-873448 (Counterclockwise)

Preceding gene: 238893053

Following gene: 238893051

Centisome position: 16.68

GC content: 55.7

Gene sequence:

>2034_bases
ATGAGCCACTATCCGCACCTTTTCAGTCCGTTGACCATCAACGGTATGACGTTAAAAAACCGCATTATTATGCCCCCTAT
GGGCACCAATATGGCCACGCTCAATGGCGAGGTGTCGCAGGAACAGCTGGAATACTACGAACTGCGGGCCAAAGGCGGCA
CCGGGCTTATCACCATCGAAAATATTTGTATTGATTTCCCCTTCGCCTCCAACGGCACCACCCAACTGCGCATCGATAAC
GATCAATATATTCCACGGCTGTTTAAATTAACCGAGACCCTGCATAAACATGGCGCCTGCGTATCCATTCAGTTAAATCA
TGCCGGCGCTTCCGCTTATGCCTACCGACTGGAAGGCCAGACGCCGCTCTCCTCTTCTACAACGCCGTCGAAGAAGCACG
GTAATATTCCGCGTCCGATGACCCATGAGGAAATTTATCATGCGGTAGAGAAATTTGGTGACGCCGCGGAGCGCGTTCGG
CGCGCAGGTTTTGACTGCGTCGAAATTCATGCCGGTCACTCCTATTTAATTAGCCAGTTTTTATCGCCGCTGTTTAATAA
GCGCACTGATGAATTTGGCGGCAGCGTCGAAAATCGCACTCGGATACTGAGTCTGATTGTCGATAAGGTTCGCGCCTGCG
TGGGGCCGCGTTTTCCGGTCAGCCTGCGCATCAGCGCCGACGACTTCCTCAAGGGCGGCAATACCCTCGAAGATTCCCTG
CGTATTCTTGAGCTCTGCCAGGAGAAGGTCGATATCATCAACGTCTCTGCGGCGCAGAACGACAACCTGAATCTGCAAAT
CGATCAGATGTCGCTGGAGGATGGCTGGAAGCGCTATCTCTCCCGCGCGGTGCGCGATAAATTCCATAAACCCACGGTCA
TCGCCGGCAATATTCGCACTCCGCAGGTAGCCGAAGATATCCTCGCCAGCGGCGATGCCGATCTTATCGCCATTGGCCGC
GGTCTGATTGCCGAGCCGGATTGGGTGCAGAAAGTGCAAGGCGGAAAAGAGCGACTGATGCGCAAATGTATCTCCTGCAA
CATCGGCTGCGCCGACCATCGCATCGCCCGCTCGCGCCCGCTGCGCTGTTCGATTAACCCGGATATTATTCACGGTGACG
CCTATAAAATGCGGCGCGTGAATCGCGACACTAACGTGGTGGTCATCGGCGCCGGCACCGCCGGGATGGAAGCCGCCTGC
ACCGCGGCGGAAGTTGGTTGCCATACCTGGCTGCTGGAAGCGAAAAACCACGTCGGCGGCCTCGCCAGCGAAATCTCCCG
CCTGCCGGAGAAAAAACGCATCGCTGATTTCCCGCAGTTTATGAAAAATCGTATCGCCTCGCTGGACAACCTGATGCTGC
AGATCGGCAAGCGGGCCGACGTGGCTTCAGTTTCCGCCCTGCGTCCGCATCTGATTGTCAACGCCACCGGCTCAACGCCG
CTGCTGCCGCCCATTGAAGGCTTGCGGGAAAACATTGACGTCGAGAACGGCAAGATCTTTTCCATTACCGGCATGATCGA
CAATCTGGCGAAATTTACCGATATCAAGGGCAAACGCATCGCCGTAGTCGGCGCCGGCGCCGTTGGCCTTGACGTTATCG
AATACTTTACCGCTCGCGGCGCACAGGCGGTGCTAATCGAGATGCAGGACGCCGCCGGTCGCGATCTCGACATCATTACC
AAAAATGCCATGTTGACCATGCTCGACGAGCACCAGGTCGAACAGCACATGAATACCCAACTGATGGCGGTCGCTGCCGA
CCATTTCCAGGTGAAAAATACACAGCAAACCTTCGATATTCCCTTCGACTACGGCTTTGTCTGTCTCGGGATGCGCGCCA
ACCGCACGGGTCTCGACGAGATCGAGCGCTGGGCCAATGCCAATAACGTCAAAATCATGAACATCGGCGACAGCGTGATG
GCGCGACGCATTATCGATGGCGTCCGCGAAGGCCGCAACGTACTGGATGCACTGGAAGACATGGGTGCGCTGGGCAGCCG
CGAAGCACAACGAATTCCCTTTCTAACTTATTGA

Upstream 100 bases:

>100_bases
TCGATTTTTCCCCTCGTTATCTTTTGCCACAGAGAAATATTAACTAAGGACACGCCTGGGCCCCGCATATCGGCCTCCCG
GCCTCCTGTGGAGAGAAGAG

Downstream 100 bases:

>100_bases
GGATTTTTGTCATGGCAGAACGTATTACTGGACACACTGAGCTGATTGGCCTGATCGCCACCCCGATTCGTCACAGCATG
TCGCCCACCATGCACAACGA

Product: NADH:flavin oxidoreductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MSHYPHLFSPLTINGMTLKNRIIMPPMGTNMATLNGEVSQEQLEYYELRAKGGTGLITIENICIDFPFASNGTTQLRIDN
DQYIPRLFKLTETLHKHGACVSIQLNHAGASAYAYRLEGQTPLSSSTTPSKKHGNIPRPMTHEEIYHAVEKFGDAAERVR
RAGFDCVEIHAGHSYLISQFLSPLFNKRTDEFGGSVENRTRILSLIVDKVRACVGPRFPVSLRISADDFLKGGNTLEDSL
RILELCQEKVDIINVSAAQNDNLNLQIDQMSLEDGWKRYLSRAVRDKFHKPTVIAGNIRTPQVAEDILASGDADLIAIGR
GLIAEPDWVQKVQGGKERLMRKCISCNIGCADHRIARSRPLRCSINPDIIHGDAYKMRRVNRDTNVVVIGAGTAGMEAAC
TAAEVGCHTWLLEAKNHVGGLASEISRLPEKKRIADFPQFMKNRIASLDNLMLQIGKRADVASVSALRPHLIVNATGSTP
LLPPIEGLRENIDVENGKIFSITGMIDNLAKFTDIKGKRIAVVGAGAVGLDVIEYFTARGAQAVLIEMQDAAGRDLDIIT
KNAMLTMLDEHQVEQHMNTQLMAVAADHFQVKNTQQTFDIPFDYGFVCLGMRANRTGLDEIERWANANNVKIMNIGDSVM
ARRIIDGVREGRNVLDALEDMGALGSREAQRIPFLTY

Sequences:

>Translated_677_residues
MSHYPHLFSPLTINGMTLKNRIIMPPMGTNMATLNGEVSQEQLEYYELRAKGGTGLITIENICIDFPFASNGTTQLRIDN
DQYIPRLFKLTETLHKHGACVSIQLNHAGASAYAYRLEGQTPLSSSTTPSKKHGNIPRPMTHEEIYHAVEKFGDAAERVR
RAGFDCVEIHAGHSYLISQFLSPLFNKRTDEFGGSVENRTRILSLIVDKVRACVGPRFPVSLRISADDFLKGGNTLEDSL
RILELCQEKVDIINVSAAQNDNLNLQIDQMSLEDGWKRYLSRAVRDKFHKPTVIAGNIRTPQVAEDILASGDADLIAIGR
GLIAEPDWVQKVQGGKERLMRKCISCNIGCADHRIARSRPLRCSINPDIIHGDAYKMRRVNRDTNVVVIGAGTAGMEAAC
TAAEVGCHTWLLEAKNHVGGLASEISRLPEKKRIADFPQFMKNRIASLDNLMLQIGKRADVASVSALRPHLIVNATGSTP
LLPPIEGLRENIDVENGKIFSITGMIDNLAKFTDIKGKRIAVVGAGAVGLDVIEYFTARGAQAVLIEMQDAAGRDLDIIT
KNAMLTMLDEHQVEQHMNTQLMAVAADHFQVKNTQQTFDIPFDYGFVCLGMRANRTGLDEIERWANANNVKIMNIGDSVM
ARRIIDGVREGRNVLDALEDMGALGSREAQRIPFLTY
>Mature_676_residues
SHYPHLFSPLTINGMTLKNRIIMPPMGTNMATLNGEVSQEQLEYYELRAKGGTGLITIENICIDFPFASNGTTQLRIDND
QYIPRLFKLTETLHKHGACVSIQLNHAGASAYAYRLEGQTPLSSSTTPSKKHGNIPRPMTHEEIYHAVEKFGDAAERVRR
AGFDCVEIHAGHSYLISQFLSPLFNKRTDEFGGSVENRTRILSLIVDKVRACVGPRFPVSLRISADDFLKGGNTLEDSLR
ILELCQEKVDIINVSAAQNDNLNLQIDQMSLEDGWKRYLSRAVRDKFHKPTVIAGNIRTPQVAEDILASGDADLIAIGRG
LIAEPDWVQKVQGGKERLMRKCISCNIGCADHRIARSRPLRCSINPDIIHGDAYKMRRVNRDTNVVVIGAGTAGMEAACT
AAEVGCHTWLLEAKNHVGGLASEISRLPEKKRIADFPQFMKNRIASLDNLMLQIGKRADVASVSALRPHLIVNATGSTPL
LPPIEGLRENIDVENGKIFSITGMIDNLAKFTDIKGKRIAVVGAGAVGLDVIEYFTARGAQAVLIEMQDAAGRDLDIITK
NAMLTMLDEHQVEQHMNTQLMAVAADHFQVKNTQQTFDIPFDYGFVCLGMRANRTGLDEIERWANANNVKIMNIGDSVMA
RRIIDGVREGRNVLDALEDMGALGSREAQRIPFLTY

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=538, Percent_Identity=27.3234200743494, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1787939, Length=368, Percent_Identity=31.25, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17559804, Length=310, Percent_Identity=31.2903225806452, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17559802, Length=348, Percent_Identity=27.2988505747126, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17564188, Length=315, Percent_Identity=29.2063492063492, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540738, Length=342, Percent_Identity=25.1461988304094, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17565138, Length=326, Percent_Identity=28.8343558282209, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17566914, Length=356, Percent_Identity=26.685393258427, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI72001454, Length=309, Percent_Identity=29.4498381877023, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17566916, Length=341, Percent_Identity=23.7536656891496, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321973, Length=235, Percent_Identity=32.3404255319149, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325086, Length=363, Percent_Identity=25.3443526170799, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 74836; Mature: 74705

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYPHLFSPLTINGMTLKNRIIMPPMGTNMATLNGEVSQEQLEYYELRAKGGTGLITIE
CCCCCCCCCCEEECCEEECCEEEECCCCCCEEEECCCCCHHHHHHHHEEECCCCEEEEEE
NICIDFPFASNGTTQLRIDNDQYIPRLFKLTETLHKHGACVSIQLNHAGASAYAYRLEGQ
EEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
TPLSSSTTPSKKHGNIPRPMTHEEIYHAVEKFGDAAERVRRAGFDCVEIHAGHSYLISQF
CCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHH
LSPLFNKRTDEFGGSVENRTRILSLIVDKVRACVGPRFPVSLRISADDFLKGGNTLEDSL
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCHHHHH
RILELCQEKVDIINVSAAQNDNLNLQIDQMSLEDGWKRYLSRAVRDKFHKPTVIAGNIRT
HHHHHHHHHHCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PQVAEDILASGDADLIAIGRGLIAEPDWVQKVQGGKERLMRKCISCNIGCADHRIARSRP
CHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCC
LRCSINPDIIHGDAYKMRRVNRDTNVVVIGAGTAGMEAACTAAEVGCHTWLLEAKNHVGG
CEEECCCCEEECCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
LASEISRLPEKKRIADFPQFMKNRIASLDNLMLQIGKRADVASVSALRPHLIVNATGSTP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCC
LLPPIEGLRENIDVENGKIFSITGMIDNLAKFTDIKGKRIAVVGAGAVGLDVIEYFTARG
CCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCC
AQAVLIEMQDAAGRDLDIITKNAMLTMLDEHQVEQHMNTQLMAVAADHFQVKNTQQTFDI
CEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHHEEECCCCCEEEC
PFDYGFVCLGMRANRTGLDEIERWANANNVKIMNIGDSVMARRIIDGVREGRNVLDALED
CCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
MGALGSREAQRIPFLTY
HCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SHYPHLFSPLTINGMTLKNRIIMPPMGTNMATLNGEVSQEQLEYYELRAKGGTGLITIE
CCCCCCCCCEEECCEEECCEEEECCCCCCEEEECCCCCHHHHHHHHEEECCCCEEEEEE
NICIDFPFASNGTTQLRIDNDQYIPRLFKLTETLHKHGACVSIQLNHAGASAYAYRLEGQ
EEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
TPLSSSTTPSKKHGNIPRPMTHEEIYHAVEKFGDAAERVRRAGFDCVEIHAGHSYLISQF
CCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHH
LSPLFNKRTDEFGGSVENRTRILSLIVDKVRACVGPRFPVSLRISADDFLKGGNTLEDSL
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCHHHHH
RILELCQEKVDIINVSAAQNDNLNLQIDQMSLEDGWKRYLSRAVRDKFHKPTVIAGNIRT
HHHHHHHHHHCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PQVAEDILASGDADLIAIGRGLIAEPDWVQKVQGGKERLMRKCISCNIGCADHRIARSRP
CHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCC
LRCSINPDIIHGDAYKMRRVNRDTNVVVIGAGTAGMEAACTAAEVGCHTWLLEAKNHVGG
CEEECCCCEEECCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
LASEISRLPEKKRIADFPQFMKNRIASLDNLMLQIGKRADVASVSALRPHLIVNATGSTP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCC
LLPPIEGLRENIDVENGKIFSITGMIDNLAKFTDIKGKRIAVVGAGAVGLDVIEYFTARG
CCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCC
AQAVLIEMQDAAGRDLDIITKNAMLTMLDEHQVEQHMNTQLMAVAADHFQVKNTQQTFDI
CEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHHEEECCCCCEEEC
PFDYGFVCLGMRANRTGLDEIERWANANNVKIMNIGDSVMARRIIDGVREGRNVLDALED
CCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
MGALGSREAQRIPFLTY
HCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]