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The map label for this gene is citY [H]

Identifier: 238893030

GI number: 238893030

Start: 844633

End: 846291

Strand: Reverse

Name: citY [H]

Synonym: KP1_0867

Alternate gene names: 238893030

Gene position: 846291-844633 (Counterclockwise)

Preceding gene: 238893033

Following gene: 238893029

Centisome position: 16.12

GC content: 57.81

Gene sequence:

>1659_bases
GTGCCGGTATGGTTAATACGTCGTCCGGGGCCTATGAAATTATCTTTTCAATATAAGCTGTTTATTTCTCTGGTCGCTTT
TTTCTCGGTCCTTTTTATCGCGCTGGGCATTTATTATTATTTTGACGCCAGCCGCCAGCTTTATCAGGAGATGAGCGCCC
GGGCCAAAATACAGGCCGAAGAGATAGCCCTGATGCCGAATTTACGTCAACAGGTCAGCCGGCACGACCCACAGGCGATT
CAGGCGTTTATGCAGCAAATCGCCGCCCATAGCGACGCCAGCTTTATCGTCATCGGCGACCGTCAGGGAGTTCATCTGTT
TCATTCCGTCCATCCGGAGTGGGTCGGCACCCGACTGGTCGGCGGCGACAACCAGGCGGTACTGGAAGGAAAATCCATCA
CCACCATTCGCAAAGGCGGCCTCGGGGTCTCGCTGCGCAGCAAAACGCCCATCGTTGATGACGCAGGGCGAGTGATCGGT
ATTGTCTCCGTCGGCTACCTCACCAGCTATCTCGACAGCATTACTCTGACTAAAGTGATCAATATTTTTATCGCCGCCGT
CCTGCTGCTCATCGCCCTGTTTATCTTCTCCTGGTACTTTACCCGCAGCATCAAGAAGCAGATTTTTTCGCTCGAGCCGC
GGGAAATTGGCCTGCTGGTTCGCCAGCAAAAGGCGATGATGGAGTCGATCTTTGAGGGGGTGATCGTCATCGATCGCCAG
CGGCGTATTGAGGTGATAAACCATGCCGCCCGCAGCCTGCTGGGGCTCAGCCAGCCCGCCCGCCAGCTGCGCGGTCAGTC
GATCGACAGCGTCATTTCGCCGCAGCCCTTTTTCGCCAGCGGCGACATGCTCGAACGCGATACCCACGATGAGCTGTGCC
GCTTCAACCAGTTGACCGTGCTCGCCAGTCGGGTGCGCATTATGCTGGAGAATACCCTGCAGGGCTGGGTGATCACATTC
CGTGACCGCAATGAAATCAATGCCCTCACCGCCCAGCTGAGCCAGGTGAAGCGCTATGTCGACAATCTGCGCATCATGCG
CCACGAGCAGCTCAACCGGATGACTACCCTCTCCGGCCTGCTGCATATGGGCCATTATGACGAAGCGATCCGCTATATTG
AGGCCCAGTCGGAACATGCTCAGGAGCTACTGGATTTTATCTCCTCGCACTTCCACTCGCCGACGCTATGCGGTCTGCTG
CTCGGCAAAGCCACCCGCGCCCGCGAAAAAGGCGTGGCGCTGAGCTTCGACCCGGCCTGCCGTATCGACCGCCCCCTGCC
GTCGCTAATGGAATCCGAGCTGATCTCCATCATCGGCAACCTGCTGGATAACGCCATCGAAGCCACGCAGCGTGCCGAGC
TGCCGCATGAGCCGGTTGAAGTCCTGATCCAGCTCAACGCCCGGGAGTTGATTATCGAAGTGGCCGACCGCGGCGTCGGC
ATCCGCCCCGATATCCGCGAGCGCATTTTTGAACGCGGCGTCACCACCAAAACCCGTGGCGATCACGGCATTGGTCTGTA
TCTTATTGAACATTATGTCACTCAGGCGGGCGGCACCATCGAAGTCGCCGATAACGCGCCGCGGGGAACGATCTTCACCC
TATTTATCCCGGCCGACGCGCACGCCTGTCCGCAACCGGAGGCCCATGATGCATCATGA

Upstream 100 bases:

>100_bases
GCCGCCTATTTCCGCCGCGACCGCTGGCGGCAGCCCGCACCTGCGCCGCTGATCACAACTTTCCCTTAACATTTATGTCA
CGTGACAGAAAAATGTTAGA

Downstream 100 bases:

>100_bases
CCTGGTCGATGTGCTAATTATTGAAGATGAGAGCGAACTGGCGCGCCTGCACGCCGAGCTTGTGCAAAAACACCCGCGAC
TGCGGCTGGCAGGCATGGCG

Product: two-component sensor kinase for citrate

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MPVWLIRRPGPMKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAEEIALMPNLRQQVSRHDPQAI
QAFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLVGGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIG
IVSVGYLTSYLDSITLTKVINIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQ
RRIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTVLASRVRIMLENTLQGWVITF
RDRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGHYDEAIRYIEAQSEHAQELLDFISSHFHSPTLCGLL
LGKATRAREKGVALSFDPACRIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVG
IRPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADAHACPQPEAHDAS

Sequences:

>Translated_552_residues
MPVWLIRRPGPMKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAEEIALMPNLRQQVSRHDPQAI
QAFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLVGGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIG
IVSVGYLTSYLDSITLTKVINIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQ
RRIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTVLASRVRIMLENTLQGWVITF
RDRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGHYDEAIRYIEAQSEHAQELLDFISSHFHSPTLCGLL
LGKATRAREKGVALSFDPACRIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVG
IRPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADAHACPQPEAHDAS
>Mature_551_residues
PVWLIRRPGPMKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAEEIALMPNLRQQVSRHDPQAIQ
AFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLVGGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIGI
VSVGYLTSYLDSITLTKVINIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQR
RIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTVLASRVRIMLENTLQGWVITFR
DRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGHYDEAIRYIEAQSEHAQELLDFISSHFHSPTLCGLLL
GKATRAREKGVALSFDPACRIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVGI
RPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADAHACPQPEAHDAS

Specific function: Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes [H]

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786837, Length=529, Percent_Identity=38.5633270321361, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790567, Length=549, Percent_Identity=29.8724954462659, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788549, Length=343, Percent_Identity=25.0728862973761, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62092; Mature: 61961

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVWLIRRPGPMKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAE
CCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EIALMPNLRQQVSRHDPQAIQAFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLV
HHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHCCCHHHCEEEE
GGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIGIVSVGYLTSYLDSITLTKVI
CCCCCEEEECCCEEEEECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
NIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCH
RRIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTV
HHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LASRVRIMLENTLQGWVITFRDRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGL
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHMGHYDEAIRYIEAQSEHAQELLDFISSHFHSPTLCGLLLGKATRAREKGVALSFDPAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
RIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCC
IRPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADA
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCC
HACPQPEAHDAS
CCCCCCCCCCCC
>Mature Secondary Structure 
PVWLIRRPGPMKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAE
CEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EIALMPNLRQQVSRHDPQAIQAFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLV
HHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHCCCHHHCEEEE
GGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIGIVSVGYLTSYLDSITLTKVI
CCCCCEEEECCCEEEEECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
NIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCH
RRIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTV
HHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LASRVRIMLENTLQGWVITFRDRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGL
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHMGHYDEAIRYIEAQSEHAQELLDFISSHFHSPTLCGLLLGKATRAREKGVALSFDPAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
RIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCC
IRPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADA
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCC
HACPQPEAHDAS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8748036; 10447894 [H]