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The map label for this gene is citZ [H]

Identifier: 238893029

GI number: 238893029

Start: 843945

End: 844646

Strand: Reverse

Name: citZ [H]

Synonym: KP1_0866

Alternate gene names: 238893029

Gene position: 844646-843945 (Counterclockwise)

Preceding gene: 238893030

Following gene: 238893027

Centisome position: 16.09

GC content: 58.26

Gene sequence:

>702_bases
ATGATGCATCATGACCTGGTCGATGTGCTAATTATTGAAGATGAGAGCGAACTGGCGCGCCTGCACGCCGAGCTTGTGCA
AAAACACCCGCGACTGCGGCTGGCAGGCATGGCGGCCTCCCTCGCCCAGGCGCGGCAGCTGCTTCACGCCACGCCGCCGC
AGCTGGTGCTGCTGGATAACTATTTACCGGACGGCAAAGGCGTCACGCTGATGACCGACCCGGCGCTGGCGACCAGCCAA
TGCTCGGTGATCTTTATCACCGCCGCCAGCGATATGGAAACCTGCAGCCAGGCCATCCGCAACGGCGCCTTCGACTATAT
CCTTAAGCCGGTATCATGGAAGCGGCTGAGCCAGTCGCTGGAGCGCTTTATCCAGTTCTACGATCAGCAACGGGAGTGGA
AAATCGTCGATCAGCAAAACGTCGATTCCCTCTATCAACTGCAGGCGAAGAACTATCGCGTGGATAGCGGCAGCAAGGGG
ATTGAAGAGAAAACGCTGGCGCTGGTGCAGGGACTGTTTAGCGACCGGGAAGCGCACTGTTTTTCCGTTGATGAAGTGGT
CAGCGCCGCCGGGCTTAGCAAAACCACCGCCCGTCGCTATCTGGAGCACGGCGTTGAGACCGGTTTTCTGGAAGTGGAGA
TGCTGTACGGAAAAATTGGCCATCCGCGGCGGCTGTATCGCCGCGCTAAGGTCAAAAGTTAA

Upstream 100 bases:

>100_bases
GCGGGCGGCACCATCGAAGTCGCCGATAACGCGCCGCGGGGAACGATCTTCACCCTATTTATCCCGGCCGACGCGCACGC
CTGTCCGCAACCGGAGGCCC

Downstream 100 bases:

>100_bases
AACCCCTCGCCGGACGGGAGGGGCTGGAAACGTCAGAAGCCGCGCTGCTCTTTGATCAGCTCCCAGGCCTTCTGGATCTC
CTGGGCCTTCTGTTTGGCCA

Product: two-component response regulator for citrate

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MMHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDNYLPDGKGVTLMTDPALATSQ
CSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSLERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKG
IEEKTLALVQGLFSDREAHCFSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS

Sequences:

>Translated_233_residues
MMHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDNYLPDGKGVTLMTDPALATSQ
CSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSLERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKG
IEEKTLALVQGLFSDREAHCFSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS
>Mature_233_residues
MMHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDNYLPDGKGVTLMTDPALATSQ
CSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSLERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKG
IEEKTLALVQGLFSDREAHCFSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS

Specific function: Member of the two-component regulatory system CitA/CitB essential for expression of citrate-specific fermentation genes. Phosphorylated CitB binds to two sites in the citS-citC intergenic region where it probably activates transcription of both genes [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786838, Length=218, Percent_Identity=39.4495412844037, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1790566, Length=227, Percent_Identity=28.1938325991189, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26331; Mature: 26331

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDN
CCCCCEEEEEEEECHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEC
YLPDGKGVTLMTDPALATSQCSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSL
CCCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHH
ERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKGIEEKTLALVQGLFSDREAHC
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCCCCCCE
FSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS
ECHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MMHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDN
CCCCCEEEEEEEECHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEC
YLPDGKGVTLMTDPALATSQCSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSL
CCCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHH
ERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKGIEEKTLALVQGLFSDREAHC
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCCCCCCE
FSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS
ECHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8748036; 9223636; 10447894 [H]