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The map label for this gene is arcA [H]

Identifier: 238892987

GI number: 238892987

Start: 795522

End: 796238

Strand: Reverse

Name: arcA [H]

Synonym: KP1_0818

Alternate gene names: 238892987

Gene position: 796238-795522 (Counterclockwise)

Preceding gene: 238892993

Following gene: 238892982

Centisome position: 15.17

GC content: 53.28

Gene sequence:

>717_bases
ATGCAGACCCCGCACATTCTTATCGTTGAAGACGAGTTGGTAACACGCAACACGTTAAAAAGTATTTTCGAAGCAGAAGG
TTACGATGTATTCGAAGCGACCGATGGCGCGGAAATGCATCAGATCCTGTCTGAAAATGATATCAACCTGGTGATCATGG
ATATCAACCTGCCGGGTAAAAATGGTCTTCTGCTGGCGCGCGAGCTGCGCGAGCAGGCTGACGTCGCGCTGATGTTCTTA
ACCGGCCGCGACAACGAAGTGGATAAGATCCTTGGCCTCGAAATCGGCGCTGACGACTATATCACTAAACCGTTTAACCC
GCGTGAACTGACTATTCGCGCGCGCAACCTGCTCTCCCGTACCATGAACCTCGGTACCGTGAGCGAAGAGCGTCGCAGCG
TGGAAAGCTACAAGTTCAACGGCTGGGAACTCGATATCAACAGCCGTTCCCTGGTTAGCCCGAACGGCGAACAGTACAAG
CTGCCGCGCAGTGAATTCCGCGCGATGCTGCACTTCTGCGAAAACCCGGGCAAAATTCAGTCTCGTGCCGAGCTGCTGAA
GAAAATGACCGGTCGCGAGCTGAAGCCGCATGACCGTACCGTTGACGTGACCATTCGTCGGATTCGTAAACACTTCGAAT
CCACTCCGGATACCCCGGAAATCATCGCTACCATTCACGGTGAAGGCTACCGTTTCTGTGGCGATCTGCAGGAATAA

Upstream 100 bases:

>100_bases
GTCATGTTACGCCGCGCATGTTAATTTGCGACATGCAGCAGGCAGGTCAGGGACTTTGGTACTTCCTGTTTCGATTTAGT
TGGCAATTTAGGTAGCAAAC

Downstream 100 bases:

>100_bases
TACGATTTATTCCGCAGCCATGATGCGAAAACGGCGCCCCAGGGGCGCCGTTTTTTATGCCGTCACTCTTTCCAGAGACG
CAGCTTATCGTCATCGGCAG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQADVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLVSPNGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQE

Sequences:

>Translated_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQADVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLVSPNGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQE
>Mature_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQADVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLVSPNGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=97.0588235294118, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.0600858369099, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=35.1931330472103, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=32.618025751073, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.7662337662338, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.9148936170213, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32.4444444444444, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.4410480349345, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=32.3144104803493, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=31.4410480349345, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=29.2035398230088, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.8793103448276, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=29.646017699115, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=30.7359307359307, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=25.9433962264151, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27272; Mature: 27272

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQADVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLVSPNGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCEEECCCCCEEECCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQADVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLVSPNGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCEEECCCCCEEECCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]