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The map label for this gene is trpR [H]

Identifier: 238892979

GI number: 238892979

Start: 788774

End: 789103

Strand: Direct

Name: trpR [H]

Synonym: KP1_0810

Alternate gene names: 238892979

Gene position: 788774-789103 (Clockwise)

Preceding gene: 238892978

Following gene: 238892981

Centisome position: 15.03

GC content: 60.61

Gene sequence:

>330_bases
ATGACCCAACAATCTCCCTATTCCGCGGCCGTTGCCGAACAACGTCATCAGGAGTGGCTGCGCTTTGTTGCCCTGCTTCA
GCAGGCCTATGCTGAGGATCTGCATCTGCCGTTGCTGCAGCTGATGCTGACGCCCGACGAGCGCGAAGCCCTGGGTACCC
GGGTGCGCATTATCGAAGAGTTGCTGCGCGGCGAGATGAGCCAGCGTGAGCTGAAAAATGAGCTCGGCGCCGGAATTGCG
ACCATTACCCGCGGGTCCAACAGCCTGAAATCGGCGCCGGTAGAGCTGCGCCAGTGGCTGGAGCAGACGCTGCTGGCTAG
CGATAAATAG

Upstream 100 bases:

>100_bases
CAGCGTTACTGATCGCCGGGAAGTATGTTATGCTTTGTACTCGTTGAAGAGTACATTCGACGGGCAGCGTAAGCTGCCCG
TCTCAATATGGTGGCGCGAT

Downstream 100 bases:

>100_bases
CGTTATGGAACGGGCTTAGCGCCAGCACGACCGCCTGGTGGTAAACGCTGCTGCGGGTTAATCTGCCGCCGGTGAAAACC
CCAATCGCCCCCTCTTTACG

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MTQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKNELGAGIA
TITRGSNSLKSAPVELRQWLEQTLLASDK

Sequences:

>Translated_109_residues
MTQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKNELGAGIA
TITRGSNSLKSAPVELRQWLEQTLLASDK
>Mature_108_residues
TQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKNELGAGIAT
ITRGSNSLKSAPVELRQWLEQTLLASDK

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regula

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family [H]

Homologues:

Organism=Escherichia coli, GI1790854, Length=108, Percent_Identity=87.962962962963, Blast_Score=173, Evalue=2e-45,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- ProDom:   PD012582 [H]

Pfam domain/function: PF01371 Trp_repressor [H]

EC number: NA

Molecular weight: Translated: 12397; Mature: 12266

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLRGEMSQRELKNELGAGIATITRGSNSLKSAPVELRQWLEQTLLASDK
HHHCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLRGEMSQRELKNELGAGIATITRGSNSLKSAPVELRQWLEQTLLASDK
HHHCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA