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The map label for this gene is lplA [H]

Identifier: 238892972

GI number: 238892972

Start: 779373

End: 780389

Strand: Reverse

Name: lplA [H]

Synonym: KP1_0802

Alternate gene names: 238892972

Gene position: 780389-779373 (Counterclockwise)

Preceding gene: 238892973

Following gene: 238892958

Centisome position: 14.87

GC content: 60.96

Gene sequence:

>1017_bases
ATGTCCACATTGCGCCTCCTGCTCTCTGACTCTTACGACCCGTGGTTCAACCTGGCGGTCGAGGAGTGCATTTTCCGCCA
GATGCCCGCCACCCAGCGGGTGCTGTTCCTGTGGCGCAATGCCGATACCGTGGTCATCGGCCGCGCGCAGAACCCGTGGA
AGGAGTGTAATACCCGCCGCATGGAAGAAGACCATGTGCGGCTGGCCCGTCGCAGCAGCGGCGGCGGCGCGGTGTTCCAC
GACCTCGGCAATACCTGCTTTACCTTTATGGCAGGCAAACCGGAGTACGACAAAACCGTCTCCACCGCTATTGTGCTGAC
GGCGCTTAATTCACTCGGCGTAACCGCCGAAGCCTCCGGGCGCAACGATCTGGTGGTCAAAACCGACAGCGGCGACCGCA
AAGTCTCCGGCTCCGCCTATCGTGAAACCATGGACCGCGGTTTTCATCACGGTACCCTGCTGCTCAACGCCGATTTAAGC
CGTCTCGCCAACTACCTCAACCCGGACCAGAAAAAGCTGCAGGCTAAAGGCATTACCTCGGTGCGCGGACGGGTGGCGAA
CCTGGTTGAGCTGCTGCCGGGCATTACCCATCAGCAAGTTTGCGAGGCGATCCAGGAAGCATTCTTCAGCCATTACGGCG
AACGGGTGGACGCCGAGGTGATCTCCCCGGACAACACGCCGGATCTACCAAATTTTGCTGAGACTTTCGCCCGTCAGAGC
AGCTGGGAGTGGAACTTCGGCCAGGCGCCGGCCTTCTCTCATCTTCTGGACGAGCGCTTTCGCTGGGGCGGCGTTGAGCT
GCATTTTGACGTCGAAAAAGGGCATATCACCCGCGCGCAGGCCTTTACCGATAGCCTGAACCCGGCGCCGCTGGAGGCCC
TGGCGGCACGCTTAGTCGGCTGTCAGTATCGGGCAGAAGTATTACAGCAGCAGTGCGAGGCGCTGGTCGGCGATTTCCCG
GAGCAGGAAGCGGAACTGAAAGAACTGTCGGCGTGGATTGCCGGCGCAGTGCGCTGA

Upstream 100 bases:

>100_bases
TGCTGCAGGGCAAACGCACCCGCTGGCAGCAATCGCCTTTCCTGCTCACCGCCAACAAGCCGGTTGAGGATGAAGACGAT
GAAAAGAAAGGAAATCTATA

Downstream 100 bases:

>100_bases
TAAAAAAAGCCCGCTGCGCTTAGCGGGCCAGGAAAACCGTAGGCCGGGTCAGACGAAGCCGCCACCCGGCACAACAGCTC
TTACTCTTTATCGCCCAGCA

Product: lipoate-protein ligase A

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSTLRLLLSDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDHVRLARRSSGGGAVFH
DLGNTCFTFMAGKPEYDKTVSTAIVLTALNSLGVTAEASGRNDLVVKTDSGDRKVSGSAYRETMDRGFHHGTLLLNADLS
RLANYLNPDQKKLQAKGITSVRGRVANLVELLPGITHQQVCEAIQEAFFSHYGERVDAEVISPDNTPDLPNFAETFARQS
SWEWNFGQAPAFSHLLDERFRWGGVELHFDVEKGHITRAQAFTDSLNPAPLEALAARLVGCQYRAEVLQQQCEALVGDFP
EQEAELKELSAWIAGAVR

Sequences:

>Translated_338_residues
MSTLRLLLSDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDHVRLARRSSGGGAVFH
DLGNTCFTFMAGKPEYDKTVSTAIVLTALNSLGVTAEASGRNDLVVKTDSGDRKVSGSAYRETMDRGFHHGTLLLNADLS
RLANYLNPDQKKLQAKGITSVRGRVANLVELLPGITHQQVCEAIQEAFFSHYGERVDAEVISPDNTPDLPNFAETFARQS
SWEWNFGQAPAFSHLLDERFRWGGVELHFDVEKGHITRAQAFTDSLNPAPLEALAARLVGCQYRAEVLQQQCEALVGDFP
EQEAELKELSAWIAGAVR
>Mature_337_residues
STLRLLLSDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDHVRLARRSSGGGAVFHD
LGNTCFTFMAGKPEYDKTVSTAIVLTALNSLGVTAEASGRNDLVVKTDSGDRKVSGSAYRETMDRGFHHGTLLLNADLSR
LANYLNPDQKKLQAKGITSVRGRVANLVELLPGITHQQVCEAIQEAFFSHYGERVDAEVISPDNTPDLPNFAETFARQSS
WEWNFGQAPAFSHLLDERFRWGGVELHFDVEKGHITRAQAFTDSLNPAPLEALAARLVGCQYRAEVLQQQCEALVGDFPE
QEAELKELSAWIAGAVR

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21729884, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21729882, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21729880, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21729878, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1790846, Length=338, Percent_Identity=89.6449704142012, Blast_Score=643, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71981909, Length=254, Percent_Identity=31.8897637795276, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322415, Length=284, Percent_Identity=27.8169014084507, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573464, Length=262, Percent_Identity=30.9160305343511, Blast_Score=124, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37758; Mature: 37627

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLRLLLSDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRR
CCCEEEHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHHCC
MEEDHVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTVSTAIVLTALNSLGVTAEASG
CCHHHHHHHHCCCCCCCHHHHCCCHHEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEECCC
RNDLVVKTDSGDRKVSGSAYRETMDRGFHHGTLLLNADLSRLANYLNPDQKKLQAKGITS
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCHHHHHHCCCHH
VRGRVANLVELLPGITHQQVCEAIQEAFFSHYGERVDAEVISPDNTPDLPNFAETFARQS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHCC
SWEWNFGQAPAFSHLLDERFRWGGVELHFDVEKGHITRAQAFTDSLNPAPLEALAARLVG
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
CQYRAEVLQQQCEALVGDFPEQEAELKELSAWIAGAVR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STLRLLLSDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRR
CCEEEHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHHCC
MEEDHVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTVSTAIVLTALNSLGVTAEASG
CCHHHHHHHHCCCCCCCHHHHCCCHHEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEECCC
RNDLVVKTDSGDRKVSGSAYRETMDRGFHHGTLLLNADLSRLANYLNPDQKKLQAKGITS
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCHHHHHHCCCHH
VRGRVANLVELLPGITHQQVCEAIQEAFFSHYGERVDAEVISPDNTPDLPNFAETFARQS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHCC
SWEWNFGQAPAFSHLLDERFRWGGVELHFDVEKGHITRAQAFTDSLNPAPLEALAARLVG
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
CQYRAEVLQQQCEALVGDFPEQEAELKELSAWIAGAVR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA