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The map label for this gene is hexR [H]

Identifier: 238892931

GI number: 238892931

Start: 739746

End: 740609

Strand: Reverse

Name: hexR [H]

Synonym: KP1_0756

Alternate gene names: 238892931

Gene position: 740609-739746 (Counterclockwise)

Preceding gene: 238892932

Following gene: 238892925

Centisome position: 14.11

GC content: 60.19

Gene sequence:

>864_bases
ATGTCCTGGTCAATCGATATTATTTCCTGCATAACCGATCGCTTTGTGGAACTCACGGCGACCGAAAAACGCATTGCGCA
GTTTATTCTCGATGATGTCGCGGCGGCGGCGGAGCTGCCCATCGCCGAGATAGCGCGTCTGACGCAAACCAGCCAGGCTT
CGGTCACCCGTTTTGCCCGGGCGCTCGGCTGTAAAGACGTCCGCGAGCTGAAGATGAAGCTTGCGCAATCTCTTGCGGTC
GGCCAGCGGTTTATCCTCGATGTTCCGGATCTCGAAGGCGTCCAGGGGATCTATGAGTCAATCATCAGCGTACTGGAGAC
CAACCGGCGGGCGCTGGATATCGAGGCGCTGAAGCGCGCGGTGAGCTGGCTGAGCGATGCGCGGCAGATCCTCGCCCTGG
GGATGGGCGGCGGTTCGACCATCTGCGCTCAGGAAATTCAGTATCGCCTGTTTCGCCTCGGTCTGCCGGTAGTCAGCCAG
AGCGATGGTCTGCTGGTACGCATGATGAGCTCGGCGGTGACGCCGCAGGATGTGGTGATCGTGCTGTCTCTGGGCGGCTA
TACCCGGGAAATCATCGAGAGCGCGGCGATTGCCAGCCAGTACGGCGCGAAGGTTATTGCGATTACCCCCGCCGGAACAC
CGCTGGCTGAACAGGCGGATCTGGTGCTACCGCTGCTGGTACGGGAAAACGACTATATCTTTAAGCCCAGCACTTCCCGT
TACGCGATGCTGGCGATGGTCGATGTGCTGGCCACCGAACTGGCGATGGCCAACAAAACCCAGGCAAAAGGCAAATTACG
CCGTATTAAGCTGGCGCTCGACAGCCACCGCGGCGGCGTCGATCGGCAGCCGCTGGGGGACTAA

Upstream 100 bases:

>100_bases
GTCGCGCTGCGCCATGCGCCTGGCGTTGTAGACTTCAGCACTGATTTCAGCGGCGCAATATGGTACAAAGTACCATTCAA
AACTTACCCGTTGTTACCGT

Downstream 100 bases:

>100_bases
CTTTTACTGGCGGAGATAAACCTCTCCGCCTGCTCGCGGGTACGTTCCACGGCCTGTCCGGCGCGATAAAGATCGCTGCC
CAGACCGGCACCGGCGCACC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSWSIDIISCITDRFVELTATEKRIAQFILDDVAAAAELPIAEIARLTQTSQASVTRFARALGCKDVRELKMKLAQSLAV
GQRFILDVPDLEGVQGIYESIISVLETNRRALDIEALKRAVSWLSDARQILALGMGGGSTICAQEIQYRLFRLGLPVVSQ
SDGLLVRMMSSAVTPQDVVIVLSLGGYTREIIESAAIASQYGAKVIAITPAGTPLAEQADLVLPLLVRENDYIFKPSTSR
YAMLAMVDVLATELAMANKTQAKGKLRRIKLALDSHRGGVDRQPLGD

Sequences:

>Translated_287_residues
MSWSIDIISCITDRFVELTATEKRIAQFILDDVAAAAELPIAEIARLTQTSQASVTRFARALGCKDVRELKMKLAQSLAV
GQRFILDVPDLEGVQGIYESIISVLETNRRALDIEALKRAVSWLSDARQILALGMGGGSTICAQEIQYRLFRLGLPVVSQ
SDGLLVRMMSSAVTPQDVVIVLSLGGYTREIIESAAIASQYGAKVIAITPAGTPLAEQADLVLPLLVRENDYIFKPSTSR
YAMLAMVDVLATELAMANKTQAKGKLRRIKLALDSHRGGVDRQPLGD
>Mature_286_residues
SWSIDIISCITDRFVELTATEKRIAQFILDDVAAAAELPIAEIARLTQTSQASVTRFARALGCKDVRELKMKLAQSLAVG
QRFILDVPDLEGVQGIYESIISVLETNRRALDIEALKRAVSWLSDARQILALGMGGGSTICAQEIQYRLFRLGLPVVSQS
DGLLVRMMSSAVTPQDVVIVLSLGGYTREIIESAAIASQYGAKVIAITPAGTPLAEQADLVLPLLVRENDYIFKPSTSRY
AMLAMVDVLATELAMANKTQAKGKLRRIKLALDSHRGGVDRQPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=287, Percent_Identity=33.7979094076655, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87082369, Length=268, Percent_Identity=22.3880597014925, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788767, Length=276, Percent_Identity=25.7246376811594, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082130, Length=222, Percent_Identity=28.8288288288288, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31188; Mature: 31057

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSIDIISCITDRFVELTATEKRIAQFILDDVAAAAELPIAEIARLTQTSQASVTRFAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
ALGCKDVRELKMKLAQSLAVGQRFILDVPDLEGVQGIYESIISVLETNRRALDIEALKRA
HHCHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHCCCCEECHHHHHHH
VSWLSDARQILALGMGGGSTICAQEIQYRLFRLGLPVVSQSDGLLVRMMSSAVTPQDVVI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEE
VLSLGGYTREIIESAAIASQYGAKVIAITPAGTPLAEQADLVLPLLVRENDYIFKPSTSR
EEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHEEEEEECCCEEECCCCCH
YAMLAMVDVLATELAMANKTQAKGKLRRIKLALDSHRGGVDRQPLGD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SWSIDIISCITDRFVELTATEKRIAQFILDDVAAAAELPIAEIARLTQTSQASVTRFAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
ALGCKDVRELKMKLAQSLAVGQRFILDVPDLEGVQGIYESIISVLETNRRALDIEALKRA
HHCHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHCCCCEECHHHHHHH
VSWLSDARQILALGMGGGSTICAQEIQYRLFRLGLPVVSQSDGLLVRMMSSAVTPQDVVI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEE
VLSLGGYTREIIESAAIASQYGAKVIAITPAGTPLAEQADLVLPLLVRENDYIFKPSTSR
EEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHEEEEEECCCEEECCCCCH
YAMLAMVDVLATELAMANKTQAKGKLRRIKLALDSHRGGVDRQPLGD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]