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The map label for this gene is cusS [H]

Identifier: 238892872

GI number: 238892872

Start: 676781

End: 678226

Strand: Direct

Name: cusS [H]

Synonym: KP1_0691

Alternate gene names: 238892872

Gene position: 676781-678226 (Clockwise)

Preceding gene: 238892871

Following gene: 238892873

Centisome position: 12.89

GC content: 59.47

Gene sequence:

>1446_bases
TTGAGGTGCCGGATGGCCGCTAAGCGCCCCTTTTCCCTGGCCACCCGGCTGACCTTCTTTATTAGCCTCGCCACCATCAT
TGCTTTCTTTGCCTTCACCTGGATCATGATCCATTCGGTGAAGGCCCACTTTGAAGAGCGCGACGTTCACGATCTCAGAC
AGCTCAGCACCACCCTGGAGACGGTCCTCGACCACGCTGACTACCCGCCAGCGCGACGGCTGGAGATCGTGAAGAATATC
ATTGCGGGCTACGCCAACGTCTTCATCTGCCTGGACGATGGCCAGGGCAATATTCTCTTCCAGTCGCCCAACGGGCCGGA
TCTCAGCCATATGCTGAGTACGCCGGGGCTGGCGATGCAGCTCCGTGACGGGAATGTGATTTCATGGACCGACCCGCAGC
CGCGGGCAATGGCGCACGATAATCATCCACTGGAGACCCGCGCCTGGCGGTTGATCATGCTGCCGCTGGGCAAGCAGGCG
GACGGTAAACCGGCGTACCATCTGCTGATGGCCTTATCCATCGATTTTCACCTGCACTATATTAATGAGCTGAAAGCGAA
GCTGATCTCCGCGGCGTCGATAATCAGCCTGCTGATCATCGCCATCGTGCTGTTTGTGGTCTACCAGGGGCATAAGCCGA
TCCGCCAGATCAGTCGCCAGATCCAGAATATTACCTCGCGGGATCTCGATGTGCGCCTTGACCCGCAGGCGGTGCCTGTC
GAGCTGGAGCGGCTGGCGCTGTCGTTTAACCATATGCTGGAGCGCATAGAGGATGTCTTTACCCGCCAGTCCAACTTCTC
CGCCGATATCGCCCATGAAATCCGCACGCCGATTACCAACCTGGTGACGCAAACCGAAATCGCCTTAAGCCAGAGCCGCA
GCCAGCAGGAGCTGGAAGAGGTGTTGTATTCCAATCTCGAAGAGTTCTCGCGGATGTCGCGGATGGTCAGTGATATGTTG
TTCCTCGCCCAGGCGGATAATAACCAGCTGATCCCTGAGCAACAGGCGCTGGATCTGGCCGAGGAAGTGCATAAAGTGTT
TGAGTTTTTCGAGGCGTGGGCGGAAGAGAAGGCGGTGGCGCTGCGTTTTGTCGGTAGCCCCTGCCGGGTGACGGGCGATC
CGCTGATGCTGCGGCGGGCAATCAGCAACCTGCTGTCGAACGCGATTCGCTATACGCCGGCCGGGCAGGCGGTGACCATC
CAGTTGAGCGAAAGCGCGGAGACGGTACGCCTGGTGGTGGAGAACCCCGGTACGCCGATTGCCGCCGAGCATCTGCCGCG
CCTGTTTGACCGATTCTATCGCGTCGACCCCTCGCGCCAGCGCAAAGGGGAGGGCAGCGGCATCGGCCTGGCGATTGTGA
AATCGATTGTCGGAGCCCACCACGGCAGCGTGGCGGCACAGTCCGATCTGCGCTCGACGCGGTTTATTGTGGTGTTGCCG
AAATAG

Upstream 100 bases:

>100_bases
ACTAACGCCATCGACGTGGCGGTGAAGCGGCTGCGCGCCAAAATTGATAACGACTTCGAGCCGAAGCTCATCCAGACCGT
GCGCGGCGTCGGCTACATGC

Downstream 100 bases:

>100_bases
GCGCAATCCGCGAGTGATAGTTGAGTATGTGGCTTTCTGTCGCTATATTAAATGTACGGAAAATAACCGTACATGAAGTT
TGCAACAGGCCGGAGATAAC

Product: sensor kinase CusS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRCRMAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLDHADYPPARRLEIVKNI
IAGYANVFICLDDGQGNILFQSPNGPDLSHMLSTPGLAMQLRDGNVISWTDPQPRAMAHDNHPLETRAWRLIMLPLGKQA
DGKPAYHLLMALSIDFHLHYINELKAKLISAASIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPV
ELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDML
FLAQADNNQLIPEQQALDLAEEVHKVFEFFEAWAEEKAVALRFVGSPCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTI
QLSESAETVRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVGAHHGSVAAQSDLRSTRFIVVLP
K

Sequences:

>Translated_481_residues
MRCRMAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLDHADYPPARRLEIVKNI
IAGYANVFICLDDGQGNILFQSPNGPDLSHMLSTPGLAMQLRDGNVISWTDPQPRAMAHDNHPLETRAWRLIMLPLGKQA
DGKPAYHLLMALSIDFHLHYINELKAKLISAASIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPV
ELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDML
FLAQADNNQLIPEQQALDLAEEVHKVFEFFEAWAEEKAVALRFVGSPCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTI
QLSESAETVRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVGAHHGSVAAQSDLRSTRFIVVLP
K
>Mature_481_residues
MRCRMAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLDHADYPPARRLEIVKNI
IAGYANVFICLDDGQGNILFQSPNGPDLSHMLSTPGLAMQLRDGNVISWTDPQPRAMAHDNHPLETRAWRLIMLPLGKQA
DGKPAYHLLMALSIDFHLHYINELKAKLISAASIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPV
ELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDML
FLAQADNNQLIPEQQALDLAEEVHKVFEFFEAWAEEKAVALRFVGSPCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTI
QLSESAETVRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVGAHHGSVAAQSDLRSTRFIVVLP
K

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=473, Percent_Identity=66.5961945031712, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=32.312925170068, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786600, Length=286, Percent_Identity=29.020979020979, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790346, Length=344, Percent_Identity=27.3255813953488, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=30, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789403, Length=376, Percent_Identity=27.3936170212766, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1787894, Length=325, Percent_Identity=28.3076923076923, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=25.7261410788382, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790551, Length=317, Percent_Identity=27.4447949526814, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=26.8181818181818, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=275, Percent_Identity=28.3636363636364, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789149, Length=363, Percent_Identity=23.1404958677686, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.0742358078603, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=30.3571428571429, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=25.4237288135593, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=23.8938053097345, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=24.3727598566308, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=26.6375545851528, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54164; Mature: 54164

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCRMAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
TVLDHADYPPARRLEIVKNIIAGYANVFICLDDGQGNILFQSPNGPDLSHMLSTPGLAMQ
HHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCHHHHHCCCCCEEE
LRDGNVISWTDPQPRAMAHDNHPLETRAWRLIMLPLGKQADGKPAYHLLMALSIDFHLHY
ECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
INELKAKLISAASIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCH
ELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLAEEVHKVFEFFEAWAEEKAVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LRFVGSPCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETVRLVVENPGTPI
EEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEEECCCCCH
AAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVGAHHGSVAAQSDLRSTRFIVVLP
HHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEC
K
C
>Mature Secondary Structure
MRCRMAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
TVLDHADYPPARRLEIVKNIIAGYANVFICLDDGQGNILFQSPNGPDLSHMLSTPGLAMQ
HHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCHHHHHCCCCCEEE
LRDGNVISWTDPQPRAMAHDNHPLETRAWRLIMLPLGKQADGKPAYHLLMALSIDFHLHY
ECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
INELKAKLISAASIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCH
ELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLAEEVHKVFEFFEAWAEEKAVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
LRFVGSPCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETVRLVVENPGTPI
EEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEEECCCCCH
AAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVGAHHGSVAAQSDLRSTRFIVVLP
HHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]