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The map label for this gene is cusR [H]

Identifier: 238892871

GI number: 238892871

Start: 676120

End: 676803

Strand: Direct

Name: cusR [H]

Synonym: KP1_0690

Alternate gene names: 238892871

Gene position: 676120-676803 (Clockwise)

Preceding gene: 238892865

Following gene: 238892872

Centisome position: 12.88

GC content: 60.53

Gene sequence:

>684_bases
GTGAAGATTTTGATTGTCGAAGATGAGAAGAAAACCGGAGAGTACCTGACCAAAGGGCTCACCGAGGCCGGCTTCGTCGT
CGACCTGGCCGATAACGGCCTCAACGGCTATCACCTGGCGATGACCAGCGATTACGATCTGCTGATCCTCGACATCATGC
TGCCGGATGTGAACGGTTGGGATATCGTGCGCATGCTGCGCGCCGCCGGGAAAGGCATGCCGATCCTGCTGCTTACCGCG
TTGGGCACCATTGAGCATCGGGTGAAGGGGCTGGAGCTGGGCGCTGACGACTATCTGGTAAAACCGTTCGCCTTTGCGGA
GCTGCTGGCGCGGGTGCGTACTCTGCTGCGCCGCGGGGCGGCGGTCATCGTCGAAAGCCAGTTTCAGGCGGCCGATCTCA
GCGTCGATTTGGTCAGCCGCAAGGTGACGCGCGGCGCCACCCGCATCACCCTGACCAGTAAGGAATTCACGCTGCTGGAG
TTCTTCCTGCGTCATCAGGGCGAGGTGCTGCCGCGTTCGTTAATTGCCTCGCAGGTGTGGGATATGAACTTCGACAGCGA
CACTAACGCCATCGACGTGGCGGTGAAGCGGCTGCGCGCCAAAATTGATAACGACTTCGAGCCGAAGCTCATCCAGACCG
TGCGCGGCGTCGGCTACATGCTTGAGGTGCCGGATGGCCGCTAA

Upstream 100 bases:

>100_bases
GAAAATGACAAAGCTGTCATTTTCCTGATATTTCATTGCTATCCGGAGGCGCTCCTCTAAAATTGAATACCCGCACAAAG
CGCGCGTGAAGGAGCCTGCC

Downstream 100 bases:

>100_bases
GCGCCCCTTTTCCCTGGCCACCCGGCTGACCTTCTTTATTAGCCTCGCCACCATCATTGCTTTCTTTGCCTTCACCTGGA
TCATGATCCATTCGGTGAAG

Product: DNA-binding transcriptional activator CusR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGWDIVRMLRAAGKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR

Sequences:

>Translated_227_residues
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGWDIVRMLRAAGKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR
>Mature_227_residues
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGWDIVRMLRAAGKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=94.7136563876652, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=52.0547945205479, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.3665158371041, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=37.5, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.322869955157, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=35.2422907488987, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=33.4801762114537, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=35.4545454545455, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.034632034632, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.7180616740088, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=35.7758620689655, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.7610619469027, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=28.2258064516129, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25292; Mature: 25292

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGW
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCH
DIVRMLRAAGKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGA
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
AVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVW
EEEEECCCCHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGW
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCH
DIVRMLRAAGKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGA
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
AVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVW
EEEEECCCCHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]