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The map label for this gene is cobQ [H]

Identifier: 238028351

GI number: 238028351

Start: 3191418

End: 3192893

Strand: Reverse

Name: cobQ [H]

Synonym: bglu_1g28120

Alternate gene names: 238028351

Gene position: 3192893-3191418 (Counterclockwise)

Preceding gene: 238028356

Following gene: 238028350

Centisome position: 81.73

GC content: 72.97

Gene sequence:

>1476_bases
ATGCCCCGCGGCACGCTGATGATCCAGGGCACCACCTCCGACGCCGGCAAGAGCACGCTGGTGGCCGGCCTGTGCCGGCT
CGCACGCCGCGCGGGGGCCCGCGTCGCGCCGTTCAAGCCGCAGAACATGGCGCTCAACAGCGCGGTGACGGCCGACGGCG
GCGAGATCGGCCGCGCCCAGGCGCTGCAGGCGATCGCCGCCGGCATCGAGGCCCATACCGACCTGAACCCGGTGCTGCTC
AAGCCGACCAGCGACCGCGGCTCGCAAGTGATCATCCACGGCCATGCGCACGCCAATCTCGACGCGCGCGCCTACCACGC
CTTCAAGCCGGTCGCGTTCGAGGCGGTGCTGGCGTCCTATGCGCGGCTGCGCGCCGGCTACGACGCGGTGATCGTCGAGG
GCGCGGGCAGCCCCGCCGAGATCAATCTGCGCGAGGGCGACATCGCCAACATGGGTTTCGCCGAGCGCGTCGACTGCCCG
GTGGTGCTGGTGGCCGACATCGATCGCGGCGGCGTGTTCGCGCATCTGCTCGGCACGCTCGCCTGCCTGTCCGACAGCGA
GCGCGCGCGCGTGCGCGGCTTCGTGATCAACCGCTTCCGCGGCGATCCGGCGCTGCTCGAGCCCGGCCTCGACTGGCTCG
AGCAGCGCACCGGCAAGCCCGTGCTCGGCGTGGTGCCCTACCTGCCGGGCCTCGCGCTCGACGCCGAGGACATGCTGCCG
AGCCTCGCCCACACGCGCGCCTCGGATCGCGCGGCGAGCGTGCTGCGGGTGGTCGTGCCGGCCCTGCCGCGTATCAGCAA
CCACACCGATTACGACGCGCTGCGCGCGCATCCGCGCGTCGATTTCTCGTACTGGAAGCACGGTCCGATTCCGCCCGCCG
ATCTGGTGATCCTGCCGGGCTCGAAGAGCGTGCAGCGCGATCTCGAATGGCTGCGCGCGCACGGCTGGGAGGCGGCGCTC
AAGCGCCACCTGCGTTACGGCGGCAAGGTGATCGGGATCTGCGGCGGAATGCAGATGCTGGGTCGCACGCTCGACGATCC
GCACGGCCTGGAAGGCGCGCCCGCGCGCGTGGCCGGCTTCGGGCTGCTCGATTTCGACACCACCCTGATGCCGCAGAAGA
CGCTCCTCAACGTGAGCGGGCGGCTCGGCTGGGGCGCCGGCGCCGCCGTGGCGGGCTACGAGATCCACATGGGCGAGACG
CGCGGCCCGGCGCTCGCGGCTCCCGCGCTGCTGCTCGACGGGCCGCAGGGCACGCGCCCCGACGGCGCGCGTTCGGCCGA
CGGGCAGATCCTCGCGACCTACGTGCACGGCGTGTTCGAGCGGCCCGACGCCTGCGCGGCGCTGCTCGAATGGGCGGGGC
TCGACGCGGCCGAGGCGGTGGACTGGGCCGCGCTGCGCGAGGCGTCGATCGAGCGGCTTGCCGACACGCTCGGCGTGCAT
CTCGACCTCGATCGCACCTTCGGCGCGTTCGCCTGA

Upstream 100 bases:

>100_bases
CGCGTGATTGTAACGGGGCGGGAGATAATGCGGCCTTCGCCTCCCGCCAGTTTTCGCTCCGATGACCGCTTTCGATCGCC
TGCCCGCCGGGCCGCTGCCC

Downstream 100 bases:

>100_bases
CGAGGGTGCTCCGATTCATTCTCATTGGGAAGTAATGTAAGCCGTTTCGGCGACTTATCGAGGCATCCGGCTTCGAATAC
AGTTTGCTGCCTTCCCTTTC

Product: Cobyric acid synthase CobQ

Products: ADP; Dethiobiotin; H+; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGARVAPFKPQNMALNSAVTADGGEIGRAQALQAIAAGIEAHTDLNPVLL
KPTSDRGSQVIIHGHAHANLDARAYHAFKPVAFEAVLASYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCP
VVLVADIDRGGVFAHLLGTLACLSDSERARVRGFVINRFRGDPALLEPGLDWLEQRTGKPVLGVVPYLPGLALDAEDMLP
SLAHTRASDRAASVLRVVVPALPRISNHTDYDALRAHPRVDFSYWKHGPIPPADLVILPGSKSVQRDLEWLRAHGWEAAL
KRHLRYGGKVIGICGGMQMLGRTLDDPHGLEGAPARVAGFGLLDFDTTLMPQKTLLNVSGRLGWGAGAAVAGYEIHMGET
RGPALAAPALLLDGPQGTRPDGARSADGQILATYVHGVFERPDACAALLEWAGLDAAEAVDWAALREASIERLADTLGVH
LDLDRTFGAFA

Sequences:

>Translated_491_residues
MPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGARVAPFKPQNMALNSAVTADGGEIGRAQALQAIAAGIEAHTDLNPVLL
KPTSDRGSQVIIHGHAHANLDARAYHAFKPVAFEAVLASYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCP
VVLVADIDRGGVFAHLLGTLACLSDSERARVRGFVINRFRGDPALLEPGLDWLEQRTGKPVLGVVPYLPGLALDAEDMLP
SLAHTRASDRAASVLRVVVPALPRISNHTDYDALRAHPRVDFSYWKHGPIPPADLVILPGSKSVQRDLEWLRAHGWEAAL
KRHLRYGGKVIGICGGMQMLGRTLDDPHGLEGAPARVAGFGLLDFDTTLMPQKTLLNVSGRLGWGAGAAVAGYEIHMGET
RGPALAAPALLLDGPQGTRPDGARSADGQILATYVHGVFERPDACAALLEWAGLDAAEAVDWAALREASIERLADTLGVH
LDLDRTFGAFA
>Mature_490_residues
PRGTLMIQGTTSDAGKSTLVAGLCRLARRAGARVAPFKPQNMALNSAVTADGGEIGRAQALQAIAAGIEAHTDLNPVLLK
PTSDRGSQVIIHGHAHANLDARAYHAFKPVAFEAVLASYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCPV
VLVADIDRGGVFAHLLGTLACLSDSERARVRGFVINRFRGDPALLEPGLDWLEQRTGKPVLGVVPYLPGLALDAEDMLPS
LAHTRASDRAASVLRVVVPALPRISNHTDYDALRAHPRVDFSYWKHGPIPPADLVILPGSKSVQRDLEWLRAHGWEAALK
RHLRYGGKVIGICGGMQMLGRTLDDPHGLEGAPARVAGFGLLDFDTTLMPQKTLLNVSGRLGWGAGAAVAGYEIHMGETR
GPALAAPALLLDGPQGTRPDGARSADGQILATYVHGVFERPDACAALLEWAGLDAAEAVDWAALREASIERLADTLGVHL
DLDRTFGAFA

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.3.3 [C]

Molecular weight: Translated: 52073; Mature: 51942

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGARVAPFKPQNMALNSAVTADGGEIGRAQ
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCHHH
ALQAIAAGIEAHTDLNPVLLKPTSDRGSQVIIHGHAHANLDARAYHAFKPVAFEAVLASY
HHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCHHHHHHHHHHH
ARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCPVVLVADIDRGGVFAHLLGTL
HHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHH
ACLSDSERARVRGFVINRFRGDPALLEPGLDWLEQRTGKPVLGVVPYLPGLALDAEDMLP
HHHCCCCHHHHHEEEEEECCCCCCHHCCCHHHHHHHCCCCEEEHHHCCCCCEECHHHHHH
SLAHTRASDRAASVLRVVVPALPRISNHTDYDALRAHPRVDFSYWKHGPIPPADLVILPG
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEECC
SKSVQRDLEWLRAHGWEAALKRHLRYGGKVIGICGGMQMLGRTLDDPHGLEGAPARVAGF
CHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCCCCCCCCEEEE
GLLDFDTTLMPQKTLLNVSGRLGWGAGAAVAGYEIHMGETRGPALAAPALLLDGPQGTRP
EEEECCCCCCCCHHHHCCCCCCCCCCCCEEECEEEEECCCCCCCHHCCEEEEECCCCCCC
DGARSADGQILATYVHGVFERPDACAALLEWAGLDAAEAVDWAALREASIERLADTLGVH
CCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEE
LDLDRTFGAFA
EEECCCCCCCC
>Mature Secondary Structure 
PRGTLMIQGTTSDAGKSTLVAGLCRLARRAGARVAPFKPQNMALNSAVTADGGEIGRAQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCHHH
ALQAIAAGIEAHTDLNPVLLKPTSDRGSQVIIHGHAHANLDARAYHAFKPVAFEAVLASY
HHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCHHHHHHHHHHH
ARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCPVVLVADIDRGGVFAHLLGTL
HHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHH
ACLSDSERARVRGFVINRFRGDPALLEPGLDWLEQRTGKPVLGVVPYLPGLALDAEDMLP
HHHCCCCHHHHHEEEEEECCCCCCHHCCCHHHHHHHCCCCEEEHHHCCCCCEECHHHHHH
SLAHTRASDRAASVLRVVVPALPRISNHTDYDALRAHPRVDFSYWKHGPIPPADLVILPG
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEECC
SKSVQRDLEWLRAHGWEAALKRHLRYGGKVIGICGGMQMLGRTLDDPHGLEGAPARVAGF
CHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCCCCCCCCEEEE
GLLDFDTTLMPQKTLLNVSGRLGWGAGAAVAGYEIHMGETRGPALAAPALLLDGPQGTRP
EEEECCCCCCCCHHHHCCCCCCCCCCCCEEECEEEEECCCCCCCHHCCEEEEECCCCCCC
DGARSADGQILATYVHGVFERPDACAALLEWAGLDAAEAVDWAALREASIERLADTLGVH
CCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEE
LDLDRTFGAFA
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg; Cl- [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; CO2; 7,8-Diaminononanoate [C]

Specific reaction: ATP + CO2 + 7,8-Diaminononanoate <==> ADP + Dethiobiotin + (3) H+ + Phosphate [C]

General reaction: Carboxylation; Heteroatomic ring closure [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA