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The map label for this gene is argH [H]

Identifier: 238028335

GI number: 238028335

Start: 3170272

End: 3171678

Strand: Direct

Name: argH [H]

Synonym: bglu_1g27960

Alternate gene names: 238028335

Gene position: 3170272-3171678 (Clockwise)

Preceding gene: 238028334

Following gene: 238028341

Centisome position: 81.15

GC content: 68.94

Gene sequence:

>1407_bases
ATGACATCCCAATTGCACAAAAAGGGCGAGGCCTGGTCGGCCCGCTTCTCGGAACCGATGTCGGATCTGGTCAAGCGCTA
TACCTCGTCGGTGTTTTTCGACAAGCGCCTCGCGCTCGTCGACATCGAGGGCTCGCTCGCGCATGCGAAGATGCTGGCCG
CGCAGAAGATCATCAGCACCGACGACCTCGCCGCAATCGAGCGCGGGATGGCGCAGATCCGGGGCGAAATCGAGCGCGGC
GAATTCGAATGGCAGCTCGACCTCGAGGACGTCCACCTCAACATCGAGGCGCGCCTGACCGCGCTGATCGGCGACGCCGG
CAAGCGGCTGCACACCGGCCGCTCGCGCAACGACCAGGTCGCCACCGACATCCGGCTGTGGCTGCGCGGCGAGATCGACC
GCATCGGCGAACTGCTCGGCCAGCTGCGCGGCGCCCTGCTCGACCTCGCCGAACGGCACGCCGACACGATCCTGCCCGGC
TTCACGCACCTGCAGGTCGCGCAGCCCGTCACGTTCGGCCACCACCTGCTCGCCTACGTGGAGATGTTCACGCGCGACGC
GGGCCGCCTGCGCGACTGCCGCGCGCGCGTGAACCGCCTGCCGCTCGGCGCGGCTGCGCTGGCCGGCACCAGCTACCCGA
TCGACCGCCACGCGGTGGCCGCCACGCTCGGCTTCGACGGAATCTGCGCGAACTCGCTCGACGCGGTGTCGGATCGCGAC
TTCGCGATCGAATTCACGGCCGCCGCCGCGCTGGTGATGACGCACGTCTCGCGCTTCTCCGAGGAGCTGGTGCTGTGGAT
GAGCCCGCGCGTGGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGTTCGTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAACTCGCGCGCGGCAAGACCGGCCGCGTCAACGGCCACCTGATGGCGCTCCTGACGCTGATGAAGGGCCAG
CCGCTCGCGTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCG
GATCTTCGCCGAGATGGTGGCCGGCATCACCGTGAAGGCCGAGCCGATGCGCGCCGCGGCGCTGCAGGGCTTCTCGACCG
CGACCGACCTGGCCGACTATCTGGTCAAGCGCGGGCTGGCGTTCCGCGACGCCCACGAAGCCGTCGCGCACGCCGTGAAG
ATCTGCGACGAGCGCGGCATCGACCTGGCCGAGCTCACGCTCGACGAAATGAAGCGCGACCTGCCGAACGTGGCGCACCT
GATCGGCGACGACGTGTTCTCGTACCTGACGCTCGAAGGCTCGGTGGCGAGCCGCAACCACCCGGGCGGCACGGCGCCGG
ACCAAGTGCGCGCGGCGATCGCCGCGGCGCGTGCGGCACTCGGCTGA

Upstream 100 bases:

>100_bases
CGCGCCTGCCGCCCGGCGCCGGTCGGCCCGCGCGTCGCCGAATGCTAGAATCCCCACCTGCCCCGCGGCGCTCGCCGCGT
CACTCCCATTACTCATCGCC

Downstream 100 bases:

>100_bases
CGCGCGCGCGACACCATGCCCAGCCGGCCGGCTGGGCAGCCAGGAAAAACGGACGCCGAGGCGTCCGTTTTTTTTGGGGC
TTGTGGACCGCGCGCGTCAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTSQLHKKGEAWSARFSEPMSDLVKRYTSSVFFDKRLALVDIEGSLAHAKMLAAQKIISTDDLAAIERGMAQIRGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGELLGQLRGALLDLAERHADTILPG
FTHLQVAQPVTFGHHLLAYVEMFTRDAGRLRDCRARVNRLPLGAAALAGTSYPIDRHAVAATLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKAEPMRAAALQGFSTATDLADYLVKRGLAFRDAHEAVAHAVK
ICDERGIDLAELTLDEMKRDLPNVAHLIGDDVFSYLTLEGSVASRNHPGGTAPDQVRAAIAAARAALG

Sequences:

>Translated_468_residues
MTSQLHKKGEAWSARFSEPMSDLVKRYTSSVFFDKRLALVDIEGSLAHAKMLAAQKIISTDDLAAIERGMAQIRGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGELLGQLRGALLDLAERHADTILPG
FTHLQVAQPVTFGHHLLAYVEMFTRDAGRLRDCRARVNRLPLGAAALAGTSYPIDRHAVAATLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKAEPMRAAALQGFSTATDLADYLVKRGLAFRDAHEAVAHAVK
ICDERGIDLAELTLDEMKRDLPNVAHLIGDDVFSYLTLEGSVASRNHPGGTAPDQVRAAIAAARAALG
>Mature_467_residues
TSQLHKKGEAWSARFSEPMSDLVKRYTSSVFFDKRLALVDIEGSLAHAKMLAAQKIISTDDLAAIERGMAQIRGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGELLGQLRGALLDLAERHADTILPGF
THLQVAQPVTFGHHLLAYVEMFTRDAGRLRDCRARVNRLPLGAAALAGTSYPIDRHAVAATLGFDGICANSLDAVSDRDF
AIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKAEPMRAAALQGFSTATDLADYLVKRGLAFRDAHEAVAHAVKI
CDERGIDLAELTLDEMKRDLPNVAHLIGDDVFSYLTLEGSVASRNHPGGTAPDQVRAAIAAARAALG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.6963123644252, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.6963123644252, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.527114967462, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.0932754880694, Blast_Score=307, Evalue=2e-83,
Organism=Escherichia coli, GI1790398, Length=461, Percent_Identity=45.5531453362256, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=40.3050108932462, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=38.6160714285714, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=38.6160714285714, Blast_Score=305, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51196; Mature: 51065

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSDLVKRYTSSVFFDKRLALVDIEGSLAHAKMLAAQKIIST
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
DDLAAIERGMAQIRGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCHHCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGELLGQLRGALLDLAERHADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHH
EMFTRDAGRLRDCRARVNRLPLGAAALAGTSYPIDRHAVAATLGFDGICANSLDAVSDRD
HHHHHCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
EPMRAAALQGFSTATDLADYLVKRGLAFRDAHEAVAHAVKICDERGIDLAELTLDEMKRD
CCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPNVAHLIGDDVFSYLTLEGSVASRNHPGGTAPDQVRAAIAAARAALG
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSDLVKRYTSSVFFDKRLALVDIEGSLAHAKMLAAQKIIST
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
DDLAAIERGMAQIRGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCHHCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGELLGQLRGALLDLAERHADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHH
EMFTRDAGRLRDCRARVNRLPLGAAALAGTSYPIDRHAVAATLGFDGICANSLDAVSDRD
HHHHHCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
EPMRAAALQGFSTATDLADYLVKRGLAFRDAHEAVAHAVKICDERGIDLAELTLDEMKRD
CCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPNVAHLIGDDVFSYLTLEGSVASRNHPGGTAPDQVRAAIAAARAALG
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA