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The map label for this gene is hemC [H]

Identifier: 238028332

GI number: 238028332

Start: 3164762

End: 3165730

Strand: Reverse

Name: hemC [H]

Synonym: bglu_1g27930

Alternate gene names: 238028332

Gene position: 3165730-3164762 (Counterclockwise)

Preceding gene: 238028336

Following gene: 238028331

Centisome position: 81.04

GC content: 71.72

Gene sequence:

>969_bases
ATGAATTCCGAGACTCTTACGGCCGACGTTCCGGCGACGCTCACGATCGCTTCGCGGGAGAGCCGCCTCGCGATGTGGCA
GGCTGAACATGTGCGTGACGCGCTGCGCAAATTATATCCAGCTTGCGACGTGAAGATCCTCGGGATGACGACCCGGGGGG
ATCAGATCCTCGATCGCACGCTCTCGAAGGTCGGCGGCAAGGGCCTGTTCGTGAAGGAACTCGAGACCGCGCTGGCCGAC
GGCCGTGCCGACCTCGCCGTCCATTCCCTGAAGGACGTGCCGATGTCGCTGCCCGAGGGCTTCGCGCTCACGGCCGTGAT
GCGTCGCGAGGACCCGCGCGACGCGTTCGTGTCGAACGACTACGCGTCGCTCGACGAGTTGCCCACCGGCTCGATCGTCG
GCACCTCCAGCCTGCGCCGCGAGGCGATGCTGCGCGCACGCTATCTCGATATCGACGTGCGGCCGCTGCGCGGCAACCTC
GACACGCGGCTGGCCAAGCTGGACCGGGGCGACTACGCGGCGATCATCCTCGCCGCGGCGGGGCTCAAGCGGCTCGGGCT
CGACGCGCGGATCCGCTCGCTGATCGAGGTCGAGGCGAGCCCGCCCGCGGCCGGGCAGGGCGCGCTCGGCATCGAGATCG
CGGCGGCGCGCGCCGAGCTCGCGCGCTGGCTCGCGCCGCTGCACGACCCGGCCACGGCGCTCGCCTGCGAGGCCGAGCGC
ATGGTCTCGCGCGCGCTCGGCGGCAGCTGCGAGGTGCCGCTCGCCGCCCACGCGGTATGGGACGGCGACGTGCTGCAGTT
GACGGGCCGCGTCTCGAACCCGAGCGGCACGCGCGTGCTCAATGCGCGTGCGCGGGCGGCCGTTTCGACGCCCGACGCGG
CGCTCGCGCTGGGCCGGCAGGTCGCCGACGAGCTGGCGCGGCAAGGTGCCTTCGAGATCGTCGAGGCACTGCTCGGAGGG
CGCTCCTGA

Upstream 100 bases:

>100_bases
CGGGCGACCCCGGCGCATGCGCCCGGGCCGCCTGAAAAGGGGGACGGGCGTGCGTGCTACCATTGTTCGTCCCTGATTCC
CGTCCTTCGATGCCGCTGCA

Downstream 100 bases:

>100_bases
TGGCCGCCGCCCGCGCGTTCACGGCGGTGCTGACCAAGCCCGAGGGGCAATCGGCGGCGCTCGCCGCGCAGCTCGCGGCG
GCCGGCATCGAAAGCTTCGA

Product: Porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNSETLTADVPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELETALAD
GRADLAVHSLKDVPMSLPEGFALTAVMRREDPRDAFVSNDYASLDELPTGSIVGTSSLRREAMLRARYLDIDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLDARIRSLIEVEASPPAAGQGALGIEIAAARAELARWLAPLHDPATALACEAER
MVSRALGGSCEVPLAAHAVWDGDVLQLTGRVSNPSGTRVLNARARAAVSTPDAALALGRQVADELARQGAFEIVEALLGG
RS

Sequences:

>Translated_322_residues
MNSETLTADVPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELETALAD
GRADLAVHSLKDVPMSLPEGFALTAVMRREDPRDAFVSNDYASLDELPTGSIVGTSSLRREAMLRARYLDIDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLDARIRSLIEVEASPPAAGQGALGIEIAAARAELARWLAPLHDPATALACEAER
MVSRALGGSCEVPLAAHAVWDGDVLQLTGRVSNPSGTRVLNARARAAVSTPDAALALGRQVADELARQGAFEIVEALLGG
RS
>Mature_322_residues
MNSETLTADVPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELETALAD
GRADLAVHSLKDVPMSLPEGFALTAVMRREDPRDAFVSNDYASLDELPTGSIVGTSSLRREAMLRARYLDIDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLDARIRSLIEVEASPPAAGQGALGIEIAAARAELARWLAPLHDPATALACEAER
MVSRALGGSCEVPLAAHAVWDGDVLQLTGRVSNPSGTRVLNARARAAVSTPDAALALGRQVADELARQGAFEIVEALLGG
RS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=280, Percent_Identity=43.5714285714286, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI20149500, Length=280, Percent_Identity=43.5714285714286, Blast_Score=224, Evalue=5e-59,
Organism=Escherichia coli, GI48994974, Length=309, Percent_Identity=51.1326860841424, Blast_Score=284, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=38.2445141065831, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=43.75, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34302; Mature: 34302

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETLTADVPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELETALADGRADLAVHSLKDVPMSLPEGFALTAVMRREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCC
YASLDELPTGSIVGTSSLRREAMLRARYLDIDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHHCCCCCCEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLDARIRSLIEVEASPPAAGQGALGIEIAAARAELARWLAPLHDPATALACEAER
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MVSRALGGSCEVPLAAHAVWDGDVLQLTGRVSNPSGTRVLNARARAAVSTPDAALALGRQ
HHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEHHHHHHCCCCHHHHHHHHH
VADELARQGAFEIVEALLGGRS
HHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNSETLTADVPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELETALADGRADLAVHSLKDVPMSLPEGFALTAVMRREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCC
YASLDELPTGSIVGTSSLRREAMLRARYLDIDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHHCCCCCCEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLDARIRSLIEVEASPPAAGQGALGIEIAAARAELARWLAPLHDPATALACEAER
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MVSRALGGSCEVPLAAHAVWDGDVLQLTGRVSNPSGTRVLNARARAAVSTPDAALALGRQ
HHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEHHHHHHCCCCHHHHHHHHH
VADELARQGAFEIVEALLGGRS
HHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA