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The map label for this gene is hisM [H]

Identifier: 238028318

GI number: 238028318

Start: 3148078

End: 3148791

Strand: Direct

Name: hisM [H]

Synonym: bglu_1g27790

Alternate gene names: 238028318

Gene position: 3148078-3148791 (Clockwise)

Preceding gene: 238028317

Following gene: 238028319

Centisome position: 80.59

GC content: 65.83

Gene sequence:

>714_bases
ATGATCGAACTGATTCAGGAATACTGGCGCAACTACCTCTACACCGACGGCTATCACATCACCGGCGTGGCGATCACCCT
GTGGCTGCTGGTGGTGTCGATCGGCCTCGGCTTCTGCCTGTCGGTGCCGCTCGCTTGCGCGCGCGTGTCGAAGCGCAAGT
GGCTGGCCGGCGCGGTGTGGCTCTATACCTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTGCTGCTCTGCTACACG
GGCCTCTACAGCCTGCAGGCGGTGCGCGGCACGCCGCTGTTGAACGAGTTCTTCCGCGACGGCATGCACTGCACGCTGCT
CGCGTTCACGCTCAACACCTGCGCCTACACCACCGAGATCTTCGCCGGCGCGATCAAGGCGACCGCCTACGGCGAGATCG
AGGCCGCGCGCGCCTACGGGATGTCCACCTTCACGCTCTACCGCCGCGTGATCCTGCCCTCCGCGCTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAGGTGATCCTGATGCTGCACGCCACCACGGTGGCGTTCACGGCCACCGTGCCCGACATCCTGAA
GATCGCGCGCGACGTCAACTCGGCCACCTACATGTCGTTCCACGCGTTCGGCATCGCCGCGCTCCTCTATCTCGCGATCT
CGTTTACGCTCGTGTGGCTGTTCCGCCAGGCCGAGCGGCGCTGGCTCGCCTACCTGCGCCCGCAAGGCAAATAA

Upstream 100 bases:

>100_bases
TGCTCGCGGGGGCCATCTACCTCGCGATCACGACGATCTCGAACTTCGTGCTGATGTGGCTGGAAAAGCGCTACTCCACG
GGCGTCCGCAAGGCTGACCT

Downstream 100 bases:

>100_bases
ACGGCGCGAGGACTCCTGATGAATTCCAAGATGCACAAGCTTTTCGTCGACGATCTCCACAAGCAGTACGGCAGCAACGA
AGTCCTGAAGGGCGTGTCGC

Product: histidine/lysine/arginine/ornithine ABC transporter permease HisM

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGYHITGVAITLWLLVVSIGLGFCLSVPLACARVSKRKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPLLNEFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATAYGEIEAARAYGMSTFTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRQAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGYHITGVAITLWLLVVSIGLGFCLSVPLACARVSKRKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPLLNEFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATAYGEIEAARAYGMSTFTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRQAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGYHITGVAITLWLLVVSIGLGFCLSVPLACARVSKRKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPLLNEFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATAYGEIEAARAYGMSTFTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRQAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=65.2542372881356, Blast_Score=325, Evalue=1e-90,
Organism=Escherichia coli, GI1787086, Length=178, Percent_Identity=35.9550561797753, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=33.0143540669856, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787030, Length=210, Percent_Identity=29.5238095238095, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788646, Length=215, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786873, Length=223, Percent_Identity=26.9058295964126, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI48994930, Length=184, Percent_Identity=29.3478260869565, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787087, Length=124, Percent_Identity=26.6129032258064, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26848; Mature: 26848

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGYHITGVAITLWLLVVSIGLGFCLSVPLACARVSKRKWLAGAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPLLNEFFRDGMHCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATAYGEIEAARAYGMSTFTLYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGYHITGVAITLWLLVVSIGLGFCLSVPLACARVSKRKWLAGAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPLLNEFFRDGMHCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATAYGEIEAARAYGMSTFTLYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]