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The map label for this gene is envZ [H]

Identifier: 238028313

GI number: 238028313

Start: 3143246

End: 3144559

Strand: Reverse

Name: envZ [H]

Synonym: bglu_1g27740

Alternate gene names: 238028313

Gene position: 3144559-3143246 (Counterclockwise)

Preceding gene: 238028314

Following gene: 238028311

Centisome position: 80.5

GC content: 72.75

Gene sequence:

>1314_bases
ATGCGCAGACCCATTGATTCGCTGTTCGGCCGGCTCGCCATGCTGGTGGTGGGCGTGCTGCTGCTGTCGCACTTCGCGTG
GTACCTGGCGATCCGGCTCGACCGCAACGAATCGCAGATGCGCTATGCCGTGGAGGAGGCCGCGTTCCTCGTCGAAGCGG
TCCGCCAGCACGAGCAGCACACGCCGGACCAGCCGCTGCCCTCGCGGGTGCGGATCGTGCCGCCCGACAGCCCCGACGTG
CCGCGTGAAGACCCCGACATGGCGGCGCCCCCGAAGCGCTTCCTCGACGATCTGCGCGACCGCATGCCGGCCGGCACCGA
GGTGCGCTTCGGCCAGCCGGGCAAGCCGCCCGTGCTGTGGGTGAAGGAGCCGAACGACCGCAACTGGATCGTGGTGCCCG
CGCAGCCGTTGCGGCCGCGCCGCTCGCGCGACCGCATGCTGATGTGGCTCGGGATGATCTTCTCGGCCGCGGTGATGGCG
GCGCTGTTCGCCGCCTGGCAGTTGCAGCAGCCGCTGCGTTCGCTGGCGCGCGCGGTGGGCCGCTTCGGCCGCGGCATGAC
GGTGCCGCCGGTGCGCGAGGCCGGCCCGCGCGAGCTGCGCCAGCTCACGCGCGGCTTCAACCAGATGGTCGAGCAGGTGT
CGCGCGCCGAGAACGATCGCGCCGTGATGCTGGCCGGCGTGGCGCACGACCTGCGCACGCCGCTCGCGCGCATGCGGCTG
CGCGCCGAGATGATGGACGACATGCGGCTGCGCGACGGCGTGGTACGCGACGTCGATTCGATGTCGCACATCGTCGACCA
GTTCCTCGTGTTCGCGCACGGCGGCGTCGATCGCAGCGAGGTGGTGGAGGTCGATCAGGCCTGCGAGCGGATCGCACGCA
CCTATCGGGCGGTCGCGCCGAACGCGCCGACGGTCGACGTCGCGCTCGCGGCGGGCAGCGGCTTCCGGCTGCCGGCCGCG
ACGCTCGACCGGATTCTCTCGAACCTGCTCGACAATGCGCACGCCTATGGCGCGCCGCCGGTGCGGGTCGCCACCGAGCG
CACCGGCGAGGGTTACCTGCTGAGCGTGAGCGACCACGGCAAGGGCATCGCGCAGCGCGACCTGGCCGACGCCACGCGGC
CGTTCGTGCGGCTCGACCCGGCGCGCGGCGGCAACGGCCACAGCGGGCTCGGGCTCGCCATCGTCGAGCGGCTCGTGCAG
CGCCTCGGCGGGACGTGCCGGATCGGTAACCAGGAGCAGGGGGGGCTGCGCGTCGCGATGGTGTTCCCGTTGGACGCGGT
GCCCAAACCCGAACGCGACCCCGCGGGGGCGTGA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGGCGGATCCTGGAAAGCGATCCTTCCACGCCGCGCTTCATCCAGACCGTGCGTGGCCGCGGCTACGTGTT
CGTGCCCAACGGCGAGGCCC

Downstream 100 bases:

>100_bases
GCCGCCGGGACTCGAAAGCAAGCGGAGAGGGCCGGCGCGGCGGGCGCCGCGCCGGCGTGTCGGGCTACTCGCCGAACAGC
GACCCGAGCGTTTCCGCCGC

Product: Osmolarity sensor protein EnvZ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRRPIDSLFGRLAMLVVGVLLLSHFAWYLAIRLDRNESQMRYAVEEAAFLVEAVRQHEQHTPDQPLPSRVRIVPPDSPDV
PREDPDMAAPPKRFLDDLRDRMPAGTEVRFGQPGKPPVLWVKEPNDRNWIVVPAQPLRPRRSRDRMLMWLGMIFSAAVMA
ALFAAWQLQQPLRSLARAVGRFGRGMTVPPVREAGPRELRQLTRGFNQMVEQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDMRLRDGVVRDVDSMSHIVDQFLVFAHGGVDRSEVVEVDQACERIARTYRAVAPNAPTVDVALAAGSGFRLPAA
TLDRILSNLLDNAHAYGAPPVRVATERTGEGYLLSVSDHGKGIAQRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RLGGTCRIGNQEQGGLRVAMVFPLDAVPKPERDPAGA

Sequences:

>Translated_437_residues
MRRPIDSLFGRLAMLVVGVLLLSHFAWYLAIRLDRNESQMRYAVEEAAFLVEAVRQHEQHTPDQPLPSRVRIVPPDSPDV
PREDPDMAAPPKRFLDDLRDRMPAGTEVRFGQPGKPPVLWVKEPNDRNWIVVPAQPLRPRRSRDRMLMWLGMIFSAAVMA
ALFAAWQLQQPLRSLARAVGRFGRGMTVPPVREAGPRELRQLTRGFNQMVEQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDMRLRDGVVRDVDSMSHIVDQFLVFAHGGVDRSEVVEVDQACERIARTYRAVAPNAPTVDVALAAGSGFRLPAA
TLDRILSNLLDNAHAYGAPPVRVATERTGEGYLLSVSDHGKGIAQRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RLGGTCRIGNQEQGGLRVAMVFPLDAVPKPERDPAGA
>Mature_437_residues
MRRPIDSLFGRLAMLVVGVLLLSHFAWYLAIRLDRNESQMRYAVEEAAFLVEAVRQHEQHTPDQPLPSRVRIVPPDSPDV
PREDPDMAAPPKRFLDDLRDRMPAGTEVRFGQPGKPPVLWVKEPNDRNWIVVPAQPLRPRRSRDRMLMWLGMIFSAAVMA
ALFAAWQLQQPLRSLARAVGRFGRGMTVPPVREAGPRELRQLTRGFNQMVEQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDMRLRDGVVRDVDSMSHIVDQFLVFAHGGVDRSEVVEVDQACERIARTYRAVAPNAPTVDVALAAGSGFRLPAA
TLDRILSNLLDNAHAYGAPPVRVATERTGEGYLLSVSDHGKGIAQRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RLGGTCRIGNQEQGGLRVAMVFPLDAVPKPERDPAGA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=323, Percent_Identity=32.5077399380805, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=30.5343511450382, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=28.1481481481481, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790551, Length=330, Percent_Identity=26.0606060606061, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=281, Percent_Identity=26.3345195729537, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.8135593220339, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=27.0742358078603, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=24.1610738255034, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=25.296442687747, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790861, Length=303, Percent_Identity=26.7326732673267, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48446; Mature: 48446

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPIDSLFGRLAMLVVGVLLLSHFAWYLAIRLDRNESQMRYAVEEAAFLVEAVRQHEQH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRIVPPDSPDVPREDPDMAAPPKRFLDDLRDRMPAGTEVRFGQPGKPPVLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEE
VKEPNDRNWIVVPAQPLRPRRSRDRMLMWLGMIFSAAVMAALFAAWQLQQPLRSLARAVG
EECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMTVPPVREAGPRELRQLTRGFNQMVEQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDMRLRDGVVRDVDSMSHIVDQFLVFAHGGVDRSEVVEVDQACERIARTYRAVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NAPTVDVALAAGSGFRLPAATLDRILSNLLDNAHAYGAPPVRVATERTGEGYLLSVSDHG
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCC
KGIAQRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRLGGTCRIGNQEQGGLRVAM
CCHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEEEE
VFPLDAVPKPERDPAGA
EECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRPIDSLFGRLAMLVVGVLLLSHFAWYLAIRLDRNESQMRYAVEEAAFLVEAVRQHEQH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRIVPPDSPDVPREDPDMAAPPKRFLDDLRDRMPAGTEVRFGQPGKPPVLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEE
VKEPNDRNWIVVPAQPLRPRRSRDRMLMWLGMIFSAAVMAALFAAWQLQQPLRSLARAVG
EECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMTVPPVREAGPRELRQLTRGFNQMVEQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDMRLRDGVVRDVDSMSHIVDQFLVFAHGGVDRSEVVEVDQACERIARTYRAVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
NAPTVDVALAAGSGFRLPAATLDRILSNLLDNAHAYGAPPVRVATERTGEGYLLSVSDHG
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCC
KGIAQRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRLGGTCRIGNQEQGGLRVAM
CCHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEEEE
VFPLDAVPKPERDPAGA
EECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]