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The map label for this gene is comC [H]

Identifier: 238027719

GI number: 238027719

Start: 2325783

End: 2326856

Strand: Reverse

Name: comC [H]

Synonym: bglu_1g21400

Alternate gene names: 238027719

Gene position: 2326856-2325783 (Counterclockwise)

Preceding gene: 238027720

Following gene: 238027718

Centisome position: 59.56

GC content: 71.14

Gene sequence:

>1074_bases
ATGAAACATCTGATCCAGGCGGAACGACTCCGCCAACTCTGCGAGACGGCCGCGCTGCGGCGCGGCCTGAGCGCGACCCA
CGCTGCCTGGTTCGCGCACGGCCTGGTCCGCACCTCGCTGATGGGCATCGACACGCATGGCGTGCGGCTGCTGCCGCTCT
ATCTGCGTGAGCTCGACGAAGGGCGCAGCAATCCCGAGCCGGCGCTGCGCACCGTGCGGCGCTTTCAGGGCACTGCGCTC
GTCGACGCCGACGCGGCGCCGGGCGTGGTGGCCGGTAGCCACGCGGCGCGCCTCGCGAGCGAACTGGCGCGCGAGTGCGG
GGTGGGCGTGGTGGCGGTGGCGAATTCGAATCATTTCGGAGCCGCGTCGGTGTACGGCGAATGGATCGCCGCGCAAGGGC
TGATCGGCATCGTGACGACCAGCGCCGCGGCACGCATGGCGCCGTTCAACGCGACCCGCGCGATGTTCGGCACCAATCCG
ATCTGCTTCGCCGCGCCGGCCCGCGACGGCGACCTGTACCTGCTCGACATGGCCACCAGCCAGATCTCTTACTCGCAGGT
CAAGCACTTCCGCCGCAACGGCATGGCGCTGCCGTCGGGCTGGGCGCTCGGCGCCGACGGCCAGCCGGTGACCGATCCGG
CGCAAGTGGTCTCGCTCGCGACGCTCGGCGGCTACAAGGGGCAGGGGCTCGCGATGATGGTGCAGATCCTCAGCTGCCTG
CTCACCGCGATGCCGCTCGATCACGCGCTGACGCATCTCGACGCCGAGCCCTACGACCGCGGCCGCGAGATCGGCCACTG
CCTGATCGCGATCGACCCGGCCCGGTTCGGTTCGCTCGACGCCTTCACGGCCGGCGTGTCCTCGCTGATGCAGGCGATCC
GCGAGACGCCCGCCGCCGAAGGCGAGCGCGTGCAGGTCGCGGGCGACCCGCAGAAGGCCGCGATCGCGCGCCGCACCGCG
CAGGGCATCCCGCTCGACGACGACGAGTGGCGCGGCCTGCAGGCCGAAGCCGAGCGTCTCGGCCTCGGCCATCTCTTCTC
GACCGACGACATGCCGCACAAGGAGACCGCATGA

Upstream 100 bases:

>100_bases
TTCTTTCAGACCGGCGCCGCCGAGCCGCGCGTGCGCGAGCCGATCTACCTCGCGCCCGCCGGCGCGGCCGAATCCTCCCT
CACGCTTGCGAGCTGACGAC

Downstream 100 bases:

>100_bases
CATCCCCCCACACCCTGCCGTTCGATCAGCGCGACGGCCAGATCTGGTTCGACGGCGAATTCGTCGAGTGGAAGCACGCC
AAGATTCACGTGCTCACGCA

Product: malate/L-lactate dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKHLIQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSNPEPALRTVRRFQGTAL
VDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASVYGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNP
ICFAAPARDGDLYLLDMATSQISYSQVKHFRRNGMALPSGWALGADGQPVTDPAQVVSLATLGGYKGQGLAMMVQILSCL
LTAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAEGERVQVAGDPQKAAIARRTA
QGIPLDDDEWRGLQAEAERLGLGHLFSTDDMPHKETA

Sequences:

>Translated_357_residues
MKHLIQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSNPEPALRTVRRFQGTAL
VDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASVYGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNP
ICFAAPARDGDLYLLDMATSQISYSQVKHFRRNGMALPSGWALGADGQPVTDPAQVVSLATLGGYKGQGLAMMVQILSCL
LTAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAEGERVQVAGDPQKAAIARRTA
QGIPLDDDEWRGLQAEAERLGLGHLFSTDDMPHKETA
>Mature_357_residues
MKHLIQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSNPEPALRTVRRFQGTAL
VDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASVYGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNP
ICFAAPARDGDLYLLDMATSQISYSQVKHFRRNGMALPSGWALGADGQPVTDPAQVVSLATLGGYKGQGLAMMVQILSCL
LTAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAEGERVQVAGDPQKAAIARRTA
QGIPLDDDEWRGLQAEAERLGLGHLFSTDDMPHKETA

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=337, Percent_Identity=32.3442136498516, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787020, Length=349, Percent_Identity=29.512893982808, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790000, Length=335, Percent_Identity=25.0746268656716, Blast_Score=114, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17507179, Length=355, Percent_Identity=28.169014084507, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17536633, Length=356, Percent_Identity=27.247191011236, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45553211, Length=306, Percent_Identity=31.6993464052288, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24667912, Length=306, Percent_Identity=31.6993464052288, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24667904, Length=306, Percent_Identity=31.6993464052288, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24667908, Length=306, Percent_Identity=31.6993464052288, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24658010, Length=314, Percent_Identity=27.0700636942675, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648360, Length=292, Percent_Identity=26.3698630136986, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 37992; Mature: 37992

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLIQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDE
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GRSNPEPALRTVRRFQGTALVDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFG
CCCCCCHHHHHHHHHCCCEEEECCCCCCCEECHHHHHHHHHHHHHCCCEEEEEECCCCCC
AASVYGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNPICFAAPARDGDLYLLDMATS
HHHHHHHHHHHCCCCEEEEHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCEEEEECCHH
QISYSQVKHFRRNGMALPSGWALGADGQPVTDPAQVVSLATLGGYKGQGLAMMVQILSCL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LTAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAE
HHHCCHHHHHHHCCCCHHHCCHHHCEEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCC
GERVQVAGDPQKAAIARRTAQGIPLDDDEWRGLQAEAERLGLGHLFSTDDMPHKETA
CCEEEECCCCHHHHHHHHHHCCCCCCCHHCCCCHHHHHHCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MKHLIQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDE
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GRSNPEPALRTVRRFQGTALVDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFG
CCCCCCHHHHHHHHHCCCEEEECCCCCCCEECHHHHHHHHHHHHHCCCEEEEEECCCCCC
AASVYGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNPICFAAPARDGDLYLLDMATS
HHHHHHHHHHHCCCCEEEEHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCEEEEECCHH
QISYSQVKHFRRNGMALPSGWALGADGQPVTDPAQVVSLATLGGYKGQGLAMMVQILSCL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LTAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAE
HHHCCHHHHHHHCCCCHHHCCHHHCEEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCC
GERVQVAGDPQKAAIARRTAQGIPLDDDEWRGLQAEAERLGLGHLFSTDDMPHKETA
CCEEEECCCCHHHHHHHHHHCCCCCCCHHCCCCHHHHHHCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]