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The map label for this gene is kgtP [H]

Identifier: 238027457

GI number: 238027457

Start: 2038636

End: 2039940

Strand: Reverse

Name: kgtP [H]

Synonym: bglu_1g18600

Alternate gene names: 238027457

Gene position: 2039940-2038636 (Counterclockwise)

Preceding gene: 238027458

Following gene: 238027454

Centisome position: 52.22

GC content: 67.51

Gene sequence:

>1305_bases
ATGACCGATCTCACCGATCCGGCCCACCTGGCCGCCAACGACACCCGCCGACGCGTCTTCGCGATCGTCGGCGCCTCGTC
GGGCAATCTCGTCGAATGGTTCGACTTCTACATCTATTCGTTCTGCTCGCTCTACTTCGCGCACGCGTTCTTTCCGAGCG
GCAATCCCACCACGCAGCTGCTCAACACCGCCGGCGTGTTCGCGGCCGGCTTCCTGATGCGGCCGATCGGCGGCTGGCTG
TTCGGCCGCATCGCCGACCGGCGCGGCCGGCGCACCGCGATGATGATCTCGGTGCTGATGATGTGCGGCGGCTCGCTGGT
GATCGCGGCGCTGCCCACCTACGACCAGATCGGCGCGCTCGCGCCGGTGATGCTGCTGGTGGCGCGGCTGTTGCAGGGGC
TGTCGGTGGGCGGCGAGTACGGCACCAGCGCGACCTACATGAGCGAGGTCGCGCTGAAGGGCCGGCGCGGCTTCTTCGCC
TCGTTCCAGTACGTGACGCTGATCGGCGGCCAGCTCTGCGCGCTGCTGGTGCTGGTGATCCTGCAGCAGTTCCTCACCAC
CGAGGAACTGCGCGCCTGGGGCTGGCGGATTCCGTTCCTGGTCGGCGCGCTGGCCGCGCTGGTGTCGCTCTACCTGCGCA
AGTCGCTCGGCGAGACCTCCACCCGCGAATCGCGCCATGCGCGCGACGCCGGCACGATCCGCGGCGTGATGCAGCACAAG
GGCGCGTTCTTCACGGTGGTCGGCTTCACGGCAGGCGGCTCGCTGATCTTCTACACGTTCACCACCTACATGCAGAAGTA
CCTCGTCAACACGGCGGGCATGCCTGCGAAGACGGCCAGCAACGTGATGACGATGGCGCTGCTCGTCTACATGCTGCTGC
AGCCGGTGTTCGGCGCGCTGTCGGACCGCATCGGCCGGCGCAGCTCGATGCTGCTGTTCGGCGGCCTCGCGGTGCTCGGC
ACGGTGCCGCTGATGCATGCGATCGCCGGCACCAGGAGCCCGATGACGGCATTCGTGCTGATCACGGTCGCGCTCGCCGT
CGTCAGCTTCTATACCTCGATCAGCGGCCTGATCAAGGCCGAGATGTTTCCGCCCGAAGTCCGCGCGATGGGCGTGGGCC
TTTCTTACGCGGTGGCCAATGCGCTGTTCGGCGGCACGGCCGAGTACGTGGCGCTGTGGTTCAAGCAGGCCGGCACCGAG
GCGACGTTCTACTGGTACGTGACGGCGCTGTGCGCGATCTCGTTCCTGGTGTCGTGGCGCATGCGCGACCCGGCCAGGGA
AGGCTATCTGCGGCACGAGCCGTGA

Upstream 100 bases:

>100_bases
CGTGCACCGGCCGCCCGGCGCGGCCGGGTGCGCCATGCGCAGCGCGCGTCGCGCCCATGCCCCCGCACGCATCCCACGAC
CCATCGAGGACCGCAACTGC

Downstream 100 bases:

>100_bases
GCGGCGGCGCCGCCGGCGTAACGGCGCGATCGCGATAACGATATCGGAAATGCTTGGTTGTGGTCACGCGGCGGGCCCCT
TAATCTGAACCCGTAGTTCG

Product: major facilitator superfamily metabolite/H symporter

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTDLTDPAHLAANDTRRRVFAIVGASSGNLVEWFDFYIYSFCSLYFAHAFFPSGNPTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADRRGRRTAMMISVLMMCGGSLVIAALPTYDQIGALAPVMLLVARLLQGLSVGGEYGTSATYMSEVALKGRRGFFA
SFQYVTLIGGQLCALLVLVILQQFLTTEELRAWGWRIPFLVGALAALVSLYLRKSLGETSTRESRHARDAGTIRGVMQHK
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMPAKTASNVMTMALLVYMLLQPVFGALSDRIGRRSSMLLFGGLAVLG
TVPLMHAIAGTRSPMTAFVLITVALAVVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANALFGGTAEYVALWFKQAGTE
ATFYWYVTALCAISFLVSWRMRDPAREGYLRHEP

Sequences:

>Translated_434_residues
MTDLTDPAHLAANDTRRRVFAIVGASSGNLVEWFDFYIYSFCSLYFAHAFFPSGNPTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADRRGRRTAMMISVLMMCGGSLVIAALPTYDQIGALAPVMLLVARLLQGLSVGGEYGTSATYMSEVALKGRRGFFA
SFQYVTLIGGQLCALLVLVILQQFLTTEELRAWGWRIPFLVGALAALVSLYLRKSLGETSTRESRHARDAGTIRGVMQHK
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMPAKTASNVMTMALLVYMLLQPVFGALSDRIGRRSSMLLFGGLAVLG
TVPLMHAIAGTRSPMTAFVLITVALAVVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANALFGGTAEYVALWFKQAGTE
ATFYWYVTALCAISFLVSWRMRDPAREGYLRHEP
>Mature_433_residues
TDLTDPAHLAANDTRRRVFAIVGASSGNLVEWFDFYIYSFCSLYFAHAFFPSGNPTTQLLNTAGVFAAGFLMRPIGGWLF
GRIADRRGRRTAMMISVLMMCGGSLVIAALPTYDQIGALAPVMLLVARLLQGLSVGGEYGTSATYMSEVALKGRRGFFAS
FQYVTLIGGQLCALLVLVILQQFLTTEELRAWGWRIPFLVGALAALVSLYLRKSLGETSTRESRHARDAGTIRGVMQHKG
AFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMPAKTASNVMTMALLVYMLLQPVFGALSDRIGRRSSMLLFGGLAVLGT
VPLMHAIAGTRSPMTAFVLITVALAVVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANALFGGTAEYVALWFKQAGTEA
TFYWYVTALCAISFLVSWRMRDPAREGYLRHEP

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=417, Percent_Identity=67.3860911270983, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1788292, Length=430, Percent_Identity=29.7674418604651, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1790550, Length=428, Percent_Identity=26.8691588785047, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1789941, Length=403, Percent_Identity=32.258064516129, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082231, Length=318, Percent_Identity=26.7295597484277, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87082404, Length=370, Percent_Identity=25.4054054054054, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 47278; Mature: 47147

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTDPAHLAANDTRRRVFAIVGASSGNLVEWFDFYIYSFCSLYFAHAFFPSGNPTTQL
CCCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LNTAGVFAAGFLMRPIGGWLFGRIADRRGRRTAMMISVLMMCGGSLVIAALPTYDQIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
APVMLLVARLLQGLSVGGEYGTSATYMSEVALKGRRGFFASFQYVTLIGGQLCALLVLVI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LQQFLTTEELRAWGWRIPFLVGALAALVSLYLRKSLGETSTRESRHARDAGTIRGVMQHK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMPAKTASNVMTMALLVYMLLQPVFGAL
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SDRIGRRSSMLLFGGLAVLGTVPLMHAIAGTRSPMTAFVLITVALAVVSFYTSISGLIKA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMFPPEVRAMGVGLSYAVANALFGGTAEYVALWFKQAGTEATFYWYVTALCAISFLVSWR
CCCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MRDPAREGYLRHEP
CCCHHHCCCCCCCC
>Mature Secondary Structure 
TDLTDPAHLAANDTRRRVFAIVGASSGNLVEWFDFYIYSFCSLYFAHAFFPSGNPTTQL
CCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LNTAGVFAAGFLMRPIGGWLFGRIADRRGRRTAMMISVLMMCGGSLVIAALPTYDQIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
APVMLLVARLLQGLSVGGEYGTSATYMSEVALKGRRGFFASFQYVTLIGGQLCALLVLVI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LQQFLTTEELRAWGWRIPFLVGALAALVSLYLRKSLGETSTRESRHARDAGTIRGVMQHK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMPAKTASNVMTMALLVYMLLQPVFGAL
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SDRIGRRSSMLLFGGLAVLGTVPLMHAIAGTRSPMTAFVLITVALAVVSFYTSISGLIKA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMFPPEVRAMGVGLSYAVANALFGGTAEYVALWFKQAGTEATFYWYVTALCAISFLVSWR
CCCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MRDPAREGYLRHEP
CCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]