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The map label for this gene is macA [H]

Identifier: 238027231

GI number: 238027231

Start: 1773385

End: 1774488

Strand: Reverse

Name: macA [H]

Synonym: bglu_1g16170

Alternate gene names: 238027231

Gene position: 1774488-1773385 (Counterclockwise)

Preceding gene: 238027233

Following gene: 238027230

Centisome position: 45.42

GC content: 74.37

Gene sequence:

>1104_bases
GTGATTGGTTCCGGTTCCCGTGCAGTCCTCGTCGTCGGCGCCGCGCTCCTCGTCGCCGCCTGCCATCCCGGAGGCGACGG
CGCGCCTCCCGCGCCGCGCCCGGTGGTGGCCACCCCGGTGGCCGCCGACGGCGCGACCGTCGCGACCACCCTGCCCGGCG
ACGTCGAGCCGCGCTACGCCACCCCGCTGTCGTTCCGGATCGCCGGCAAGATCGTCGAGCGCAGCGTGCGGCTCGGCGAT
ACGGTGAAAAAGGGCCAAGCCGTGGCCCGGCTCGATCCCTCGGACGCCGAGAAGAACGCGGCGAGCGCGCAGGCCCAATA
CGACGCGGCCGCGCATGCGTTCAGCTATGCGCAGCAGCAGCTGGACCGCGATCGCGCGCAGGCCCGCGAGAACCTGATCG
CGCCGGCGCAGCTCGAACAGACCGAGAACGCCTACGCCTCGGCGCGCGCCCAGCGCGACCAGGCCGCCCAGCAGCTCGCG
CTGGCCAGAAACCAGCTGCAGTACACCACGCTGGTGGCCGATCACGCCGGCTACATCACGGCCGAGCAGGCCGACACCGG
TCAGAACGTGGCCGCCGGCCAGGCCGTCTACCAGCTCGCCTGGTCGGGCGACGTCGACATCGTCACCGACGTGCCCGAGG
CCACGCTCGCGCTGCTGCAGCCGGGCCACGCGGCCACCGTCACGCTGCCGGCGCTGCCGCAGCGCCGCTTCGAGGCGCGC
GTGCGCGAGATCGCGCCGGCCGCCGATCCGCAGAGCCGGACCTACCGCGTGCGGCTCACGCTCAGCCATCCCGATCCGGC
CGTGCGGCTCGGCATGACCGCCGACGTCGCGCTCGCGGGCGCTGCCGCCGACGGCGCGCGCTACACGCTGCCGTCCACCG
CGCTGTTCCACGACGGCGCGGCACCGGCCGTCTGGGTGGTCCGCCCGGACGACACGCTCGAACTGCGCCGCGTCACGGTG
GTGCGCTACGGCGAGAGCAGCGTCACCGTTTCGCAGGGCCTGCGGGCCGGCGAACGCGTCGTGCAGCAGGGCGTGCATAC
CGTCAGCGCCGGGGAGAAGGTCCGCGCGGTCGCGCCGCTGCATGCGGAGGACACCGCCTCATGA

Upstream 100 bases:

>100_bases
CCGTCTGCACCGCCGCCCTCCCGGGCGGGCGGCCCCGGCGGCGCCCGGCCAGGCGCAGCGTGCCTGCCGGATTTCCTCGG
CCTTTTCCCGTGAGGTTGCC

Downstream 100 bases:

>100_bases
GCGCTCGCGACGAAGGCCGCTTCAACCTGTCCGCCTGGGCGCTGCGCCACCAGGCGCTGGTGGTCTACCTGATCGCGCTG
GCCACGCTGGCGGGCCTGTT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MIGSGSRAVLVVGAALLVAACHPGGDGAPPAPRPVVATPVAADGATVATTLPGDVEPRYATPLSFRIAGKIVERSVRLGD
TVKKGQAVARLDPSDAEKNAASAQAQYDAAAHAFSYAQQQLDRDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLA
LARNQLQYTTLVADHAGYITAEQADTGQNVAAGQAVYQLAWSGDVDIVTDVPEATLALLQPGHAATVTLPALPQRRFEAR
VREIAPAADPQSRTYRVRLTLSHPDPAVRLGMTADVALAGAAADGARYTLPSTALFHDGAAPAVWVVRPDDTLELRRVTV
VRYGESSVTVSQGLRAGERVVQQGVHTVSAGEKVRAVAPLHAEDTAS

Sequences:

>Translated_367_residues
MIGSGSRAVLVVGAALLVAACHPGGDGAPPAPRPVVATPVAADGATVATTLPGDVEPRYATPLSFRIAGKIVERSVRLGD
TVKKGQAVARLDPSDAEKNAASAQAQYDAAAHAFSYAQQQLDRDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLA
LARNQLQYTTLVADHAGYITAEQADTGQNVAAGQAVYQLAWSGDVDIVTDVPEATLALLQPGHAATVTLPALPQRRFEAR
VREIAPAADPQSRTYRVRLTLSHPDPAVRLGMTADVALAGAAADGARYTLPSTALFHDGAAPAVWVVRPDDTLELRRVTV
VRYGESSVTVSQGLRAGERVVQQGVHTVSAGEKVRAVAPLHAEDTAS
>Mature_367_residues
MIGSGSRAVLVVGAALLVAACHPGGDGAPPAPRPVVATPVAADGATVATTLPGDVEPRYATPLSFRIAGKIVERSVRLGD
TVKKGQAVARLDPSDAEKNAASAQAQYDAAAHAFSYAQQQLDRDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLA
LARNQLQYTTLVADHAGYITAEQADTGQNVAAGQAVYQLAWSGDVDIVTDVPEATLALLQPGHAATVTLPALPQRRFEAR
VREIAPAADPQSRTYRVRLTLSHPDPAVRLGMTADVALAGAAADGARYTLPSTALFHDGAAPAVWVVRPDDTLELRRVTV
VRYGESSVTVSQGLRAGERVVQQGVHTVSAGEKVRAVAPLHAEDTAS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=336, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786787, Length=200, Percent_Identity=28.5, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=22.1875, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38412; Mature: 38412

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSGSRAVLVVGAALLVAACHPGGDGAPPAPRPVVATPVAADGATVATTLPGDVEPRYA
CCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCC
TPLSFRIAGKIVERSVRLGDTVKKGQAVARLDPSDAEKNAASAQAQYDAAAHAFSYAQQQ
CCEEHHHHHHHHHHHHHCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDRDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLALARNQLQYTTLVADHAGYIT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE
AEQADTGQNVAAGQAVYQLAWSGDVDIVTDVPEATLALLQPGHAATVTLPALPQRRFEAR
ECCCCCCCCCHHCHHHEEEEECCCCEEEECCCHHHHHHCCCCCCEEEEECCCCHHHHHHH
VREIAPAADPQSRTYRVRLTLSHPDPAVRLGMTADVALAGAAADGARYTLPSTALFHDGA
HHHHCCCCCCCCCEEEEEEEECCCCCCEEECCEEEEEEECCCCCCCEEECCCCCEECCCC
APAVWVVRPDDTLELRRVTVVRYGESSVTVSQGLRAGERVVQQGVHTVSAGEKVRAVAPL
CCEEEEECCCCCEEEEEEEEEEECCCCEEHHHHHHHHHHHHHHCCHHHCCCCCEEEECCC
HAEDTAS
CCCCCCC
>Mature Secondary Structure
MIGSGSRAVLVVGAALLVAACHPGGDGAPPAPRPVVATPVAADGATVATTLPGDVEPRYA
CCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCC
TPLSFRIAGKIVERSVRLGDTVKKGQAVARLDPSDAEKNAASAQAQYDAAAHAFSYAQQQ
CCEEHHHHHHHHHHHHHCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDRDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLALARNQLQYTTLVADHAGYIT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE
AEQADTGQNVAAGQAVYQLAWSGDVDIVTDVPEATLALLQPGHAATVTLPALPQRRFEAR
ECCCCCCCCCHHCHHHEEEEECCCCEEEECCCHHHHHHCCCCCCEEEEECCCCHHHHHHH
VREIAPAADPQSRTYRVRLTLSHPDPAVRLGMTADVALAGAAADGARYTLPSTALFHDGA
HHHHCCCCCCCCCEEEEEEEECCCCCCEEECCEEEEEEECCCCCCCEEECCCCCEECCCC
APAVWVVRPDDTLELRRVTVVRYGESSVTVSQGLRAGERVVQQGVHTVSAGEKVRAVAPL
CCEEEEECCCCCEEEEEEEEEEECCCCEEHHHHHHHHHHHHHHCCHHHCCCCCEEEECCC
HAEDTAS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]