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The map label for this gene is trxA [H]

Identifier: 238027055

GI number: 238027055

Start: 1578601

End: 1578927

Strand: Reverse

Name: trxA [H]

Synonym: bglu_1g14340

Alternate gene names: 238027055

Gene position: 1578927-1578601 (Counterclockwise)

Preceding gene: 238027065

Following gene: 238027054

Centisome position: 40.42

GC content: 58.41

Gene sequence:

>327_bases
ATGAGCGAACAGATCAAACACATCAGCGACACGTCGTTCGAACAGGACGTCGTACGATCCGACAAGCCCGTGCTGCTCGA
TTTCTGGGCCGAATGGTGCGGCCCCTGCAAGATGATCGCCCCGATCCTCGACGAAATCTCGAAGGAATACGGCGACAAGC
TGACGATCGCAAAGATCAACGTCGACGACAACACGGCGACGCCGGCGCGTTACGGTGTGCGCGGCATCCCGACGCTGATT
CTGTTCAAGAACGGCGTGCTCGCCGCACAAAAGGTCGGCGCCCTGTCCAAATCGCAATTGACCGCGTTTCTCGACAGCCA
CCTGTAA

Upstream 100 bases:

>100_bases
TGGCCGCCGTTCCCTGCGGGGCGGACCTGCCTGAACCGGCGGCCGGCGCACCTGACCGGCACCCGCAGGCAGTCCCCGAA
ACGAATGAGGTATTGACCAA

Downstream 100 bases:

>100_bases
TAAGCGATTATCTCCGCCACGCGCCTGTTGCCGGCTGGCAACAGGCGCGTGGTGCAGCCGATGTGCGGCAAAGCAAGGCC
GAATCGGCGTGTGCTAGAAT

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKHISDTSFEQDVVRSDKPVLLDFWAEWCGPCKMIAPILDEISKEYGDKLTIAKINVDDNTATPARYGVRGIPTLI
LFKNGVLAAQKVGALSKSQLTAFLDSHL

Sequences:

>Translated_108_residues
MSEQIKHISDTSFEQDVVRSDKPVLLDFWAEWCGPCKMIAPILDEISKEYGDKLTIAKINVDDNTATPARYGVRGIPTLI
LFKNGVLAAQKVGALSKSQLTAFLDSHL
>Mature_107_residues
SEQIKHISDTSFEQDVVRSDKPVLLDFWAEWCGPCKMIAPILDEISKEYGDKLTIAKINVDDNTATPARYGVRGIPTLIL
FKNGVLAAQKVGALSKSQLTAFLDSHL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=41.9354838709677, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=157, Evalue=1e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=36.9565217391304, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=34.5238095238095, Blast_Score=66, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=112, Percent_Identity=34.8214285714286, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=39.4736842105263, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=65, Percent_Identity=41.5384615384615, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=35.632183908046, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=40.2597402597403, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=36.4705882352941, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=44.1558441558442, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=37.2340425531915, Blast_Score=72, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=39.3617021276596, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=42.3076923076923, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=42.3076923076923, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=40, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=32.258064516129, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17530795, Length=74, Percent_Identity=36.4864864864865, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11935; Mature: 11804

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKHISDTSFEQDVVRSDKPVLLDFWAEWCGPCKMIAPILDEISKEYGDKLTIAKIN
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEE
VDDNTATPARYGVRGIPTLILFKNGVLAAQKVGALSKSQLTAFLDSHL
CCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEQIKHISDTSFEQDVVRSDKPVLLDFWAEWCGPCKMIAPILDEISKEYGDKLTIAKIN
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEE
VDDNTATPARYGVRGIPTLILFKNGVLAAQKVGALSKSQLTAFLDSHL
CCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496529 [H]