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The map label for this gene is fadB [H]

Identifier: 238026993

GI number: 238026993

Start: 1512147

End: 1514231

Strand: Direct

Name: fadB [H]

Synonym: bglu_1g13710

Alternate gene names: 238026993

Gene position: 1512147-1514231 (Clockwise)

Preceding gene: 238026992

Following gene: 238026994

Centisome position: 38.71

GC content: 69.64

Gene sequence:

>2085_bases
ATGGCAGTGGCTTACACGATTCGCGACGGCGTGGCCGTCCTTACGCTCGACAATCCGCCCGTCAACGGGCTCGGCCATTC
GACGCGCGCTGCGCTGATGGCCGGGCTCGACCGCGCGCTGGCCGACGCTTCGGTCACAGCGATCGTGCTGACGGGCGCCG
GCCGCGCGTTCTCGGGCGGCGCCGACATCACCGAATTCAACACGCCGAAGGCGCTGCAGGAACCGAACCTGCACACGCTG
ATCGCTGCCGTGGAGGCCAGCCCGAAGCCGGTGATCGCGGCGGTGCATGCCGTGGTGATGGGCGGCGGGCTCGAGCTCGC
GCTCGGCGCGCATTACCGGATCGCCGCGCCAGGCACCCAGGTGGCGCTGCCCGAAGTGAAGATCGGGCTGCTGCCCGGCG
CCGGCGGCACGCAGCGGCTGCCGCGCGCGGTGGGGCTGGAGACGGCGCTGAACATGATCGTCTCGGGCGCGCCGGTGCCG
GCCGAGCAGCTCGCCGCCAGCGGCCTGTTCGACGAGATCGCCGCAGGCGACCTGCTCGACGCCGCGGTGGCGTTCGGCCG
GCGCGTGGGCGCGCAGCCCGGGCCGCATCCGCGCGTGCGCGACCGCGCCATCGTGCATCCGAACCCGGCCGGCTTCATCC
AGTTCGCGCGCAACAGCGTGAAGGCGGCCGCGCCGCAGTATCCGGCGCCGCACAAGTGCATCGACGCGATCGAGTCGGGC
GTGCTGAACGGCTTCGAGCAGGGCCTGGCCGACGAGCGCGAGGGCTTCGTCGCGCTGGTGCAGACGCCCGAGAGCCGCGC
GCTGCGCCATGCGTTCTTCGCCGAGCGGGCCGCGAGCAAGATCCCCGACGTGCCGGCCGACACGCCGGTGCGCGAGATCC
GGCGGGTCGCCGTGATCGGCGCCGGCACCATGGGCGGCGGCATTGCGATGAATTTCGTCAACGCCGGGCTGCCGGTGGTG
CTGCTCGAAACGAAGCAGGAGGCGCTCGACCGCGGCCTCGCGACCATCCGCAAGAACTACGAGGCCCAGGTCAAGAAGGG
CAAGTTGACGGCCGAGAAGCTCGAGGCGCGGCTCGCGCTGATCACGCCGACGCTGTCCTACGACGACCTGGGAGAGGCCG
ACCTCATCATCGAAGCGGTATTCGAGGAGCTCGGCGTGAAGGAGCAGGTGTTTCGCCGGCTCGACGAGGTGGCCAAACCC
GGCGCGATCCTCGCGTCGAACACCTCGACGCTCGACGTCGATCGCATCGCCGCGTTCACGCAGCGCCCGCAGGACGTGGT
CGGCATGCACTTCTTCAGCCCCGCCAACGTCATGAAGCTGCTGGAAGTGGTGCGCGGCGAAAAGACGGCGAAGGACGTGC
TCGCCACCGTCATGCAGATCGCCAAGAAGATCCGCAAGACGGCCGTGGTGTCGGGCGTTTGCGACGGCTTCATCGGCAAC
CGGATGATCGAGCAGTACATCCGCCAGGCCCTCTTCATGCTCGAGGAAGGCGCGCTGCCGGCGCAGGTCGATCGCGCCAT
CGAGGCCTTCGGTTTCGCGATGGGGCCGTTTCGCATGAGCGATTTGGCCGGCAACGACATCGGCTGGGCGATCCGCAAGC
GCCGCTACGTCGAGCAGCCCGAGCTGCATTACTCGAAGATCGCCGACCGCCTCTGCGAGCTGGGCCGCTTCGGCCAGAAG
ACGGGCGGCGGCTGGTACGACTACCAGCCGGGCGAGCGGCGCGCGAAACCGTCGAAGCTCGTCGACGAGATGGTGCTCGC
CTATTCGAAGGAAGCCGGCATCGAGCGCCGCGCGATCGGCGACGACGAGATCGTCGAGCGGCTCGTCTACGCGCTCGTCA
ACGAAGGCGCGAAGATCCTCGAGGAAGGCATCGCGTCGAAGGCCTCCGACGTCGACATGGTCTACCTGACCGGCTATGGC
TTCCCGCTCTGGCGCGGCGGCCCGATGCTGTATGCCGACGAGGTCGGGGTCTACAACGTCGAGCGCGCGATGCGGCGCTA
CGCGGCCGGCGCGAACGGCGACGCGTGGCGGATCGCGCCGTCGATCGTCGAGCTGGCCGCCAGCGGCAAGGGTTTCAACG
GCTGA

Upstream 100 bases:

>100_bases
GTTCGATTGCGCGCGCCGCACGCGTTGCGCGCACCCACGACCGACAACGCTGACGACGCGCCGCCGCCCCGGGCTCGCGT
AACCGCATGGAGGCAGACAG

Downstream 100 bases:

>100_bases
CGCGCGGAGGACACGATGATGCGGACCGACGACGTGCTGCTCGTGATCGACGTGCAGAACGATTTCATGCCGGGCGGCGC
GCTCGCGGTGGCCGACGGCG

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MAVAYTIRDGVAVLTLDNPPVNGLGHSTRAALMAGLDRALADASVTAIVLTGAGRAFSGGADITEFNTPKALQEPNLHTL
IAAVEASPKPVIAAVHAVVMGGGLELALGAHYRIAAPGTQVALPEVKIGLLPGAGGTQRLPRAVGLETALNMIVSGAPVP
AEQLAASGLFDEIAAGDLLDAAVAFGRRVGAQPGPHPRVRDRAIVHPNPAGFIQFARNSVKAAAPQYPAPHKCIDAIESG
VLNGFEQGLADEREGFVALVQTPESRALRHAFFAERAASKIPDVPADTPVREIRRVAVIGAGTMGGGIAMNFVNAGLPVV
LLETKQEALDRGLATIRKNYEAQVKKGKLTAEKLEARLALITPTLSYDDLGEADLIIEAVFEELGVKEQVFRRLDEVAKP
GAILASNTSTLDVDRIAAFTQRPQDVVGMHFFSPANVMKLLEVVRGEKTAKDVLATVMQIAKKIRKTAVVSGVCDGFIGN
RMIEQYIRQALFMLEEGALPAQVDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQPELHYSKIADRLCELGRFGQK
TGGGWYDYQPGERRAKPSKLVDEMVLAYSKEAGIERRAIGDDEIVERLVYALVNEGAKILEEGIASKASDVDMVYLTGYG
FPLWRGGPMLYADEVGVYNVERAMRRYAAGANGDAWRIAPSIVELAASGKGFNG

Sequences:

>Translated_694_residues
MAVAYTIRDGVAVLTLDNPPVNGLGHSTRAALMAGLDRALADASVTAIVLTGAGRAFSGGADITEFNTPKALQEPNLHTL
IAAVEASPKPVIAAVHAVVMGGGLELALGAHYRIAAPGTQVALPEVKIGLLPGAGGTQRLPRAVGLETALNMIVSGAPVP
AEQLAASGLFDEIAAGDLLDAAVAFGRRVGAQPGPHPRVRDRAIVHPNPAGFIQFARNSVKAAAPQYPAPHKCIDAIESG
VLNGFEQGLADEREGFVALVQTPESRALRHAFFAERAASKIPDVPADTPVREIRRVAVIGAGTMGGGIAMNFVNAGLPVV
LLETKQEALDRGLATIRKNYEAQVKKGKLTAEKLEARLALITPTLSYDDLGEADLIIEAVFEELGVKEQVFRRLDEVAKP
GAILASNTSTLDVDRIAAFTQRPQDVVGMHFFSPANVMKLLEVVRGEKTAKDVLATVMQIAKKIRKTAVVSGVCDGFIGN
RMIEQYIRQALFMLEEGALPAQVDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQPELHYSKIADRLCELGRFGQK
TGGGWYDYQPGERRAKPSKLVDEMVLAYSKEAGIERRAIGDDEIVERLVYALVNEGAKILEEGIASKASDVDMVYLTGYG
FPLWRGGPMLYADEVGVYNVERAMRRYAAGANGDAWRIAPSIVELAASGKGFNG
>Mature_693_residues
AVAYTIRDGVAVLTLDNPPVNGLGHSTRAALMAGLDRALADASVTAIVLTGAGRAFSGGADITEFNTPKALQEPNLHTLI
AAVEASPKPVIAAVHAVVMGGGLELALGAHYRIAAPGTQVALPEVKIGLLPGAGGTQRLPRAVGLETALNMIVSGAPVPA
EQLAASGLFDEIAAGDLLDAAVAFGRRVGAQPGPHPRVRDRAIVHPNPAGFIQFARNSVKAAAPQYPAPHKCIDAIESGV
LNGFEQGLADEREGFVALVQTPESRALRHAFFAERAASKIPDVPADTPVREIRRVAVIGAGTMGGGIAMNFVNAGLPVVL
LETKQEALDRGLATIRKNYEAQVKKGKLTAEKLEARLALITPTLSYDDLGEADLIIEAVFEELGVKEQVFRRLDEVAKPG
AILASNTSTLDVDRIAAFTQRPQDVVGMHFFSPANVMKLLEVVRGEKTAKDVLATVMQIAKKIRKTAVVSGVCDGFIGNR
MIEQYIRQALFMLEEGALPAQVDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQPELHYSKIADRLCELGRFGQKT
GGGWYDYQPGERRAKPSKLVDEMVLAYSKEAGIERRAIGDDEIVERLVYALVNEGAKILEEGIASKASDVDMVYLTGYGF
PLWRGGPMLYADEVGVYNVERAMRRYAAGANGDAWRIAPSIVELAASGKGFNG

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI68989263, Length=710, Percent_Identity=41.6901408450704, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI261878539, Length=613, Percent_Identity=43.0668841761827, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI20127408, Length=710, Percent_Identity=31.4084507042254, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=33.6769759450172, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=31.8181818181818, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI194097323, Length=194, Percent_Identity=34.5360824742268, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI115430219, Length=213, Percent_Identity=28.169014084507, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI70995211, Length=148, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788682, Length=712, Percent_Identity=33.9887640449438, Blast_Score=327, Evalue=2e-90,
Organism=Escherichia coli, GI1790281, Length=674, Percent_Identity=32.7893175074184, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1787661, Length=294, Percent_Identity=38.7755102040816, Blast_Score=176, Evalue=6e-45,
Organism=Escherichia coli, GI1787659, Length=171, Percent_Identity=37.4269005847953, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI221142681, Length=184, Percent_Identity=30.9782608695652, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787660, Length=197, Percent_Identity=32.48730964467, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=706, Percent_Identity=33.9943342776204, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17508951, Length=727, Percent_Identity=33.2874828060523, Blast_Score=314, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17508953, Length=727, Percent_Identity=33.2874828060523, Blast_Score=314, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI25144276, Length=617, Percent_Identity=34.1977309562399, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71985923, Length=369, Percent_Identity=33.8753387533875, Blast_Score=243, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71985930, Length=385, Percent_Identity=30.1298701298701, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17553560, Length=297, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17549919, Length=296, Percent_Identity=32.7702702702703, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=32.1799307958478, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17554946, Length=189, Percent_Identity=35.4497354497354, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=168, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=188, Percent_Identity=30.3191489361702, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=179, Percent_Identity=29.608938547486, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320241, Length=209, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921000, Length=722, Percent_Identity=31.8559556786704, Blast_Score=308, Evalue=8e-84,
Organism=Drosophila melanogaster, GI24583077, Length=724, Percent_Identity=31.767955801105, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24583079, Length=724, Percent_Identity=31.767955801105, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI20129971, Length=272, Percent_Identity=30.8823529411765, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24653477, Length=272, Percent_Identity=30.8823529411765, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24653139, Length=154, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549573, Length=256, Percent_Identity=26.5625, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012799
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =5.3.3.8; =1.1.1.35 [H]

Molecular weight: Translated: 74097; Mature: 73966

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAYTIRDGVAVLTLDNPPVNGLGHSTRAALMAGLDRALADASVTAIVLTGAGRAFSGG
CEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
ADITEFNTPKALQEPNLHTLIAAVEASPKPVIAAVHAVVMGGGLELALGAHYRIAAPGTQ
CCCCCCCCCCHHCCCCHHEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCCC
VALPEVKIGLLPGAGGTQRLPRAVGLETALNMIVSGAPVPAEQLAASGLFDEIAAGDLLD
EECCCEEEEEECCCCCHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHH
AAVAFGRRVGAQPGPHPRVRDRAIVHPNPAGFIQFARNSVKAAAPQYPAPHKCIDAIESG
HHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VLNGFEQGLADEREGFVALVQTPESRALRHAFFAERAASKIPDVPADTPVREIRRVAVIG
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEE
AGTMGGGIAMNFVNAGLPVVLLETKQEALDRGLATIRKNYEAQVKKGKLTAEKLEARLAL
CCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHCEEEE
ITPTLSYDDLGEADLIIEAVFEELGVKEQVFRRLDEVAKPGAILASNTSTLDVDRIAAFT
EECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
QRPQDVVGMHFFSPANVMKLLEVVRGEKTAKDVLATVMQIAKKIRKTAVVSGVCDGFIGN
CCCHHHHCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMIEQYIRQALFMLEEGALPAQVDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCC
ELHYSKIADRLCELGRFGQKTGGGWYDYQPGERRAKPSKLVDEMVLAYSKEAGIERRAIG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCC
DDEIVERLVYALVNEGAKILEEGIASKASDVDMVYLTGYGFPLWRGGPMLYADEVGVYNV
CHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCHH
ERAMRRYAAGANGDAWRIAPSIVELAASGKGFNG
HHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVAYTIRDGVAVLTLDNPPVNGLGHSTRAALMAGLDRALADASVTAIVLTGAGRAFSGG
EEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
ADITEFNTPKALQEPNLHTLIAAVEASPKPVIAAVHAVVMGGGLELALGAHYRIAAPGTQ
CCCCCCCCCCHHCCCCHHEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCCC
VALPEVKIGLLPGAGGTQRLPRAVGLETALNMIVSGAPVPAEQLAASGLFDEIAAGDLLD
EECCCEEEEEECCCCCHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHH
AAVAFGRRVGAQPGPHPRVRDRAIVHPNPAGFIQFARNSVKAAAPQYPAPHKCIDAIESG
HHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VLNGFEQGLADEREGFVALVQTPESRALRHAFFAERAASKIPDVPADTPVREIRRVAVIG
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEE
AGTMGGGIAMNFVNAGLPVVLLETKQEALDRGLATIRKNYEAQVKKGKLTAEKLEARLAL
CCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHCEEEE
ITPTLSYDDLGEADLIIEAVFEELGVKEQVFRRLDEVAKPGAILASNTSTLDVDRIAAFT
EECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
QRPQDVVGMHFFSPANVMKLLEVVRGEKTAKDVLATVMQIAKKIRKTAVVSGVCDGFIGN
CCCHHHHCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMIEQYIRQALFMLEEGALPAQVDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCC
ELHYSKIADRLCELGRFGQKTGGGWYDYQPGERRAKPSKLVDEMVLAYSKEAGIERRAIG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCC
DDEIVERLVYALVNEGAKILEEGIASKASDVDMVYLTGYGFPLWRGGPMLYADEVGVYNV
CHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCHH
ERAMRRYAAGANGDAWRIAPSIVELAASGKGFNG
HHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA