Click here to switch to the map view.

The map label for this gene is ilvD1 [H]

Identifier: 238026986

GI number: 238026986

Start: 1503269

End: 1505128

Strand: Direct

Name: ilvD1 [H]

Synonym: bglu_1g13630

Alternate gene names: 238026986

Gene position: 1503269-1505128 (Clockwise)

Preceding gene: 238026985

Following gene: 238026992

Centisome position: 38.48

GC content: 67.69

Gene sequence:

>1860_bases
ATGCCCGCATACCGTTCCAAAACCTCCACCGCCGGCCGCAACATGGCGGGGGCGCGTTCGCTCTGGCGCGCCACCGGCAT
GAAGGACGAGGATTTCTCCAAGCCCATCATCGCCGTCGTCAACTCGTTTACCCAGTTCGTGCCCGGCCACGTCCACCTGA
AGGACCTGGGCCAGCTCGTCGCGCGCGAGATCGAGGCCGCCGGCGGCGTCGCCAAGGAGTTCAACACGATCGCCGTGGAC
GACGGCATCGCGATGGGCCACGACGGCATGCTCTATTCGCTGCCGAGCCGCGACATCATCGCCGACTCGGTCGAGTACAT
GGTGAACGCGCACTGCGCCGATGCGATGGTCTGCATCTCGAATTGCGACAAGATCACGCCGGGGATGCTGATGGCCGCGA
TGCGCCTGAACATTCCGGTGATCTTCGTGTCGGGCGGCCCGATGGAAGCGGGCAAGGCGCAACTGGCCGTGCCGGGCACC
AATACCATCCAGATCAAGAAGCTCGACCTGATCGACGCGATGGTGATGGCCGCCGACAGCAAGGTCAGCGACGCCGACGT
CGCCGAGGTCGAGCGCTCGGCCTGTCCGACCTGCGGCTCGTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTGA
CCGAGGCGCTCGGGCTCTCGCTGCCCGGCAACGGCACGATCGTCGCGACGCACGCGGACCGCGAGCTGCTGTTCAAGCGC
GCCGGCCGCCGCATCGTCGAACTCGCGCGCCAATACTACGAGCACGACGACGACAAGGTGCTGCCGCGCTCGGTCGGCTT
CAAGGCCTTCGAGAACGCCATGACGCTCGACATCGCGATGGGCGGCTCGACCAACACGATCCTGCACCTGCTCGCGATCG
CGCAGGAAGCCGAAATCGATTTCTCGATGTCGGACATCGATCGCCTGTCGCGCACCGTGCCGCAGCTCTGCAAGGTCGCG
CCGAACACCAACAAGTACCACATCGAGGACGTGCATCGCGCGGGCGGGATCATGGCGATCCTCGGCGAGCTCGAGCGCGC
CGGCAAGCTGCACACCGACGTGCCGACCGTGCACGCGCCCACGCTCGGCGCCGCGCTCGAGCAGTGGGACATCGTGCGCA
CCGGCGACGAGGCCGTCCGCACGTTCTACCTGGCTGGTCCGGGCGGAATTCCGACCCAGGTCGCGTTCAGCCAGAACGCG
CGCTGGCCTAGCCTCGATCTCGATCGCGCCGAAGGCTGCATCCGCTCCTATGAGCACGCCTTCAGCAAGGAGGGCGGCCT
CGCCGTGCTGACCGGCAACATCGCCAGGGACGGCTGCGTCGTGAAGACGGCCGGCGTGGACGACTCGATCCTCGTGTTCG
AAGGCCCGGCGCACGTGGTCGAGTCGCAGGACGAGGCGGTCGAGCACATCCTTGCCGACGAGGTGAAGGCCGGCGACGTG
GTGATCGTGCGCTACGAAGGGCCGAAGGGCGGCCCGGGCATGCAGGAGATGCTGTATCCGACCAGCTACATCAAGTCGAA
GGGGCTCGGCAAATCCTGCGCGCTGCTGACCGACGGGCGCTTCTCGGGCGGCACCTCGGGGCTGTCGATCGGGCATTGCT
CGCCGGAGGCGGCCGCGGGCGGCGCGATCGGCCTGGTGCGCAACGGCGACACGATCCGCATCGACATTCCGAACCGCACC
ATCGACGTGCTGGTGTCCGACGAGGAACTGGCCCGGCGCCGCGCCGAGCAGGACGCGAAGGGCTGGAAGCCGGCCCGGCC
ACGCCCGCGCAAGGTGTCGGCGGCGCTGAAGGCCTACGCGAAGCTGGTGATGTCGGCCGACAAGGGCGCGGTGCGGGATC
TGTCGCTGCTCGACGACTGA

Upstream 100 bases:

>100_bases
GCCTGTTGTGGTGCGTATCGGCGCGTCTGGCCGGCCCCGCAAGCCGTTCGACGGCAAGACCGCCGCTGTTTCCGTCATTC
TTATTTTCGCGACCACGACA

Downstream 100 bases:

>100_bases
GTCCGGCCGGCTCCGTGCGGCAGGCGATCGCGACCGATGCGATCGGCCCGCCGCCCGCCGTGCGCCGACGCATGCCGCCC
TCATGGGCGGTTTTTTTCGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKAQLAVPGT
NTIQIKKLDLIDAMVMAADSKVSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTIVATHADRELLFKR
AGRRIVELARQYYEHDDDKVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAEIDFSMSDIDRLSRTVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLGAALEQWDIVRTGDEAVRTFYLAGPGGIPTQVAFSQNA
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIARDGCVVKTAGVDDSILVFEGPAHVVESQDEAVEHILADEVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKSCALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRNGDTIRIDIPNRT
IDVLVSDEELARRRAEQDAKGWKPARPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Sequences:

>Translated_619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKAQLAVPGT
NTIQIKKLDLIDAMVMAADSKVSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTIVATHADRELLFKR
AGRRIVELARQYYEHDDDKVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAEIDFSMSDIDRLSRTVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLGAALEQWDIVRTGDEAVRTFYLAGPGGIPTQVAFSQNA
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIARDGCVVKTAGVDDSILVFEGPAHVVESQDEAVEHILADEVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKSCALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRNGDTIRIDIPNRT
IDVLVSDEELARRRAEQDAKGWKPARPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
>Mature_618_residues
PAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKAQLAVPGTN
TIQIKKLDLIDAMVMAADSKVSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTIVATHADRELLFKRA
GRRIVELARQYYEHDDDKVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAEIDFSMSDIDRLSRTVPQLCKVAP
NTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLGAALEQWDIVRTGDEAVRTFYLAGPGGIPTQVAFSQNAR
WPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIARDGCVVKTAGVDDSILVFEGPAHVVESQDEAVEHILADEVKAGDVV
IVRYEGPKGGPGMQEMLYPTSYIKSKGLGKSCALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRNGDTIRIDIPNRTI
DVLVSDEELARRRAEQDAKGWKPARPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=73.9130434782609, Blast_Score=937, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=584, Percent_Identity=29.9657534246575, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI2367371, Length=535, Percent_Identity=30.8411214953271, Blast_Score=185, Evalue=8e-48,
Organism=Escherichia coli, GI1786464, Length=562, Percent_Identity=31.3167259786477, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=613, Percent_Identity=37.3572593800979, Blast_Score=352, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66077; Mature: 65946

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKAQLAVPGTNTIQIKKLDLIDAMVMAADS
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHCCC
KVSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTIVATHADRELLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
AGRRIVELARQYYEHDDDKVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAEID
HCHHHHHHHHHHHCCCCCCCCCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FSMSDIDRLSRTVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGAALEQWDIVRTGDEAVRTFYLAGPGGIPTQVAFSQNARWPSLDLDRAEGCIRSYEHA
HHHHHHHHCCEEECCCHHEEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIARDGCVVKTAGVDDSILVFEGPAHVVESQDEAVEHILADEVKAGDV
HCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKSCALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRNGDTIRIDIPNRTIDVLVSDEELARRRAEQDAKGWKPARPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKAQLAVPGTNTIQIKKLDLIDAMVMAADS
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHCCC
KVSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTIVATHADRELLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
AGRRIVELARQYYEHDDDKVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAEID
HCHHHHHHHHHHHCCCCCCCCCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FSMSDIDRLSRTVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGAALEQWDIVRTGDEAVRTFYLAGPGGIPTQVAFSQNARWPSLDLDRAEGCIRSYEHA
HHHHHHHHCCEEECCCHHEEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIARDGCVVKTAGVDDSILVFEGPAHVVESQDEAVEHILADEVKAGDV
HCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKSCALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRNGDTIRIDIPNRTIDVLVSDEELARRRAEQDAKGWKPARPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA