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The map label for this gene is macA [H]

Identifier: 238026851

GI number: 238026851

Start: 1323668

End: 1324849

Strand: Direct

Name: macA [H]

Synonym: bglu_1g12170

Alternate gene names: 238026851

Gene position: 1323668-1324849 (Clockwise)

Preceding gene: 238026850

Following gene: 238026852

Centisome position: 33.88

GC content: 60.41

Gene sequence:

>1182_bases
GTGAGTAAAAAGCTTATCCAGTACGTCGCCTTAGGTTTGGCCATTTCCATCGCAGCTGCTATCGCATTCAGATATGCGCG
GCATGACAAACCGAATATTCAATGCCTTACCGTTCCCGTTTCGTATCAAGATATCGAATCCACCGTTGAGGCCGTAGGTA
CGATCCGCGCCGCCGATCTCGTGAGCGTCGGTGCGCAAGTCAATGGACAGATCAAGTCGATGCGTGTGGCGCTTGGCGAC
CACGTCAGGAAAGGTCAGCTGATCGCGGAAATCGACTCGCAGCCACAGATCTACGCATTGGACACGGCGCAGGCGCAATT
GCAAAGCGCGGTGGCCACGCTCCATTCGAGCCAGGCATCGCTGGTCCAAGCTAGGCTCGCGCTGGAACGCCAAAAGGAAC
TGGCCGAACACGACGCCGGCTCGCATGCCGATTTCGAAACGGCACAGGCGGCCTTCGATGTGGCTCGCGCCAATGTCGAA
ATGAGTCATGCCCAGATAAAGGTCGCACAGGTCAACGTGGATACCGCCCGCGTCACGCTCGGCTACACGCGCATTGTTGC
CCCGAGCGACGGAGAAATTGTCGCCGTGCTCGCCGTCGAGGGCCAAACTGTCAACGCAAATCAGACCACGCCCAATTTGG
TCAAGATCGCACGCCTGGACACGGTCGAGGTCAAGGCGCAAATCTCGGAGGCCGATGTCGTGCGGCTCAGGCCCGGTCTG
CCGGCCTATTTCACGATTCTCGGCGACCCGTCCCATCGGTACGAAACCACGCTCAAAGCGATCGAGCCTGCGCCTGACTC
GATCTTGACCGACACGGCAATCAGTACCACGACAACGTCGTCGTCAACGAATACGGCCATCTATTACAACGGCCTGCTCG
ACATGCCGAATCCCGATAACCGACTTCGCATCTCGATGACGGCCCAGGTGTCGATCGTGCTTGCACGGGCACGGCACGCG
GCGGTCGTACCGGTCGTGGCGTTGACTGCGCCCGCACACGACGGCCGGGCGACGGTGCGGCTCCTAGGGGCCGACGGCAA
CGTCACCATCCGGGCCATACGAACCGGCATTGCCAACGATACCGTTGTCCAGGTCCTCGGCGGGCTTGGTGCGGGCGATC
GAGTCATCGTCGGTCAGGCTTCGGGCGCGGGGACGCGTGATCCTTACAGCATGCCAAGGTAA

Upstream 100 bases:

>100_bases
TGAGTCGGCCATCGACACCGGATTGCGGGGCGTGTTTATGCACGACACGTCATCGAGCGCGAAGGCAAGCGAGGACTTCG
CATAAGAAGGTGCATGCGTC

Downstream 100 bases:

>100_bases
CGGAATGTCCATGCCACGTGTCGAGTCGCCGGCGGCTCCACTGATCGAACTCCTGGGTGTGAGCCACATCTATGGCGCCG
CAGAGGCGGCGGTCAAGGTC

Product: Drug-efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKKLIQYVALGLAISIAAAIAFRYARHDKPNIQCLTVPVSYQDIESTVEAVGTIRAADLVSVGAQVNGQIKSMRVALGD
HVRKGQLIAEIDSQPQIYALDTAQAQLQSAVATLHSSQASLVQARLALERQKELAEHDAGSHADFETAQAAFDVARANVE
MSHAQIKVAQVNVDTARVTLGYTRIVAPSDGEIVAVLAVEGQTVNANQTTPNLVKIARLDTVEVKAQISEADVVRLRPGL
PAYFTILGDPSHRYETTLKAIEPAPDSILTDTAISTTTTSSSTNTAIYYNGLLDMPNPDNRLRISMTAQVSIVLARARHA
AVVPVVALTAPAHDGRATVRLLGADGNVTIRAIRTGIANDTVVQVLGGLGAGDRVIVGQASGAGTRDPYSMPR

Sequences:

>Translated_393_residues
MSKKLIQYVALGLAISIAAAIAFRYARHDKPNIQCLTVPVSYQDIESTVEAVGTIRAADLVSVGAQVNGQIKSMRVALGD
HVRKGQLIAEIDSQPQIYALDTAQAQLQSAVATLHSSQASLVQARLALERQKELAEHDAGSHADFETAQAAFDVARANVE
MSHAQIKVAQVNVDTARVTLGYTRIVAPSDGEIVAVLAVEGQTVNANQTTPNLVKIARLDTVEVKAQISEADVVRLRPGL
PAYFTILGDPSHRYETTLKAIEPAPDSILTDTAISTTTTSSSTNTAIYYNGLLDMPNPDNRLRISMTAQVSIVLARARHA
AVVPVVALTAPAHDGRATVRLLGADGNVTIRAIRTGIANDTVVQVLGGLGAGDRVIVGQASGAGTRDPYSMPR
>Mature_392_residues
SKKLIQYVALGLAISIAAAIAFRYARHDKPNIQCLTVPVSYQDIESTVEAVGTIRAADLVSVGAQVNGQIKSMRVALGDH
VRKGQLIAEIDSQPQIYALDTAQAQLQSAVATLHSSQASLVQARLALERQKELAEHDAGSHADFETAQAAFDVARANVEM
SHAQIKVAQVNVDTARVTLGYTRIVAPSDGEIVAVLAVEGQTVNANQTTPNLVKIARLDTVEVKAQISEADVVRLRPGLP
AYFTILGDPSHRYETTLKAIEPAPDSILTDTAISTTTTSSSTNTAIYYNGLLDMPNPDNRLRISMTAQVSIVLARARHAA
VVPVVALTAPAHDGRATVRLLGADGNVTIRAIRTGIANDTVVQVLGGLGAGDRVIVGQASGAGTRDPYSMPR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=376, Percent_Identity=38.8297872340425, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789929, Length=324, Percent_Identity=28.3950617283951, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082036, Length=332, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786668, Length=344, Percent_Identity=28.4883720930233, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41604; Mature: 41473

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLIQYVALGLAISIAAAIAFRYARHDKPNIQCLTVPVSYQDIESTVEAVGTIRAADL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
VSVGAQVNGQIKSMRVALGDHVRKGQLIAEIDSQPQIYALDTAQAQLQSAVATLHSSQAS
HHCCCCCCCCHHEEEEHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHCCHHH
LVQARLALERQKELAEHDAGSHADFETAQAAFDVARANVEMSHAQIKVAQVNVDTARVTL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEEEECCEEEEEE
GYTRIVAPSDGEIVAVLAVEGQTVNANQTTPNLVKIARLDTVEVKAQISEADVVRLRPGL
EEEEEECCCCCCEEEEEEECCEEECCCCCCCCEEEEEEECEEEEEEECCCCCEEEECCCC
PAYFTILGDPSHRYETTLKAIEPAPDSILTDTAISTTTTSSSTNTAIYYNGLLDMPNPDN
CEEEEEECCCCHHHHHHHHHCCCCCCCCEECCEEEEEECCCCCCEEEEEECEECCCCCCC
RLRISMTAQVSIVLARARHAAVVPVVALTAPAHDGRATVRLLGADGNVTIRAIRTGIAND
EEEEEEEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCH
TVVQVLGGLGAGDRVIVGQASGAGTRDPYSMPR
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKKLIQYVALGLAISIAAAIAFRYARHDKPNIQCLTVPVSYQDIESTVEAVGTIRAADL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
VSVGAQVNGQIKSMRVALGDHVRKGQLIAEIDSQPQIYALDTAQAQLQSAVATLHSSQAS
HHCCCCCCCCHHEEEEHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHCCHHH
LVQARLALERQKELAEHDAGSHADFETAQAAFDVARANVEMSHAQIKVAQVNVDTARVTL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEEEECCEEEEEE
GYTRIVAPSDGEIVAVLAVEGQTVNANQTTPNLVKIARLDTVEVKAQISEADVVRLRPGL
EEEEEECCCCCCEEEEEEECCEEECCCCCCCCEEEEEEECEEEEEEECCCCCEEEECCCC
PAYFTILGDPSHRYETTLKAIEPAPDSILTDTAISTTTTSSSTNTAIYYNGLLDMPNPDN
CEEEEEECCCCHHHHHHHHHCCCCCCCCEECCEEEEEECCCCCCEEEEEECEECCCCCCC
RLRISMTAQVSIVLARARHAAVVPVVALTAPAHDGRATVRLLGADGNVTIRAIRTGIAND
EEEEEEEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCH
TVVQVLGGLGAGDRVIVGQASGAGTRDPYSMPR
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]