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The map label for this gene is ytcI [H]

Identifier: 238026830

GI number: 238026830

Start: 1305248

End: 1306870

Strand: Reverse

Name: ytcI [H]

Synonym: bglu_1g11900

Alternate gene names: 238026830

Gene position: 1306870-1305248 (Counterclockwise)

Preceding gene: 238026831

Following gene: 238026829

Centisome position: 33.45

GC content: 72.03

Gene sequence:

>1623_bases
ATGCTGCCCGAAGCCGACGATTACCCCGCCCTGCTTGCCGCCTTTTCATGGCGGATTCCCGAGCGCTACAACATCGGCGC
GGACGTCTGCGACCGCTGGGCCGACGGCAGCGGCCGGCTCGCGCTGATCGACGAGCGCGACGACGGCCGCGTCACGCGCC
ATACGTTCGATGCGCTGAAGGCGGCCTCGAACCGGCTCGCGAACAGCTTCGCGCGGCTCGGCGTGGTGCGCGGCGAGCGC
GTCGGCATCTTCATCGCGCAGGGCGTGCAGACCGCCGTCGCGCATCTGGCCGCCTACAAGGCCGGGGCGATCGCGGTGCC
GCTGTTCGCGCTGTTCGGTGCCGAGGCGCTGGAGTTCCGCCTCGCCGACAGCGGCGCCGCCGCGCTCGTCACCGATCGGG
CCGGCGCAGCGAAGATCGCGCCGCTGCGCGCGGCGTTGCCGGCGCTGCGCACGGTCTACTGCATCGACGACGACAGCGGC
GGCGTGCCCGAGGGCTGCCTGTCGTTCGAGGCGGCGCTGGCCGCCGAATCCGACCGCTACACACCGGTCGACACGCTGGC
CGACGACCCGGCCATGATCATCTACACGTCGGGCACCACGGGCAAGCCGAAGGGAGCGCTGCACGCGCACCGCGTGCTGC
TCGGCCACCTGCCGGGCGTGGAGATGTCGCAGAACGGTTTTCCCCGCCGCGCGCGCGCGTTCTGGACGCCCGCGGACTGG
GCCTGGATCGGCGGCCTGCTGGACGTGCTGCTGCCGGCCTGGCATCACGGCGTGACGGTGGTGGCGCGGCGCTTCGAGAA
GTTCGACGGCGAGGCGGCGTTCGCGCTGCTGGCGCGCCACCAGGTCAGCCACGCATTCCTGCCGCCCACCGCGCTGAAGC
TGATGCGCGGCGTGGCGCGGCCGCGCGAGCGTCATGCGCTGCGGATCGAATCGGTGGCAAGCGGCGGCGAATCGCTCGGC
AGCGAGTTGCTCGAATGGGGCCGCGAGGCGTTCGGCGTGACCATCAACGAGTTCTACGGGCAGACCGAATGCAACGTCGT
GCTGGCCTCGTGCAGCGCACTGTTCGCGCCGCGCGCGGGCGCGATCGGCAAGGCCGCGCCGGGCCATTGCGTCATGATCG
TCGACGCCGCGGGCACGCCGGTGCCAGCCGGCGTCGAGGGCAACATCGGCATCCGTGCGCCGGACCCGGTGATGTTTCTC
GGCTACTGGCGCAACCCGGCCGCCACGCGCGAGAAATTCGCCGGCGACGTCCTGCTGACCGGGGATCGCGGCGTGGCCGA
CGAGGATGGCTTCATCCGCTTCGTCGGCCGCGACGACGACGTGATCACGAGCGCCGGCTACCGGATCGGCCCCGGCCCGA
TCGAGGACTGCCTGCTGCGCCACCCGGCCGTGCGCATGGCCGCCGTGGTCGGCGTGCCGGATGCCGTGCGCACCGAGATC
GTCAAGGCTTTCGTGGTGGTCCAGCCCGGCGTGGAAGCCGGCGACGCCCTCGTGCGCGAACTGCAGCAGCATGTGCGCAC
GCGCCTCGCCGCGCACGAATATCCGCGCGCGATCGCGTTCGTCGAGAGCCTGCCGATGACAGCGACCGGCAAGATCATCC
GGCGCGCCTTGCGCGACGCGTAG

Upstream 100 bases:

>100_bases
GTAGCGGAGCGTTGCACGGCAAGACTGTCATGCGAGCAGCGTGACGATCCGGTGTAATGTCGTCGGAATTCGCGACACGA
GACTCTTGCCAGGAGCGCCG

Downstream 100 bases:

>100_bases
CGCCGCAACACCGGCCTGCCCGGGCGGGCGAGCCGGCGCCCGTGCCGCCCTGCCTGCGGGCCTGGTGCACGCCGGTCGCG
CGCCGGTCGAGCACCGGTCA

Product: AMP-binding enzyme

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MLPEADDYPALLAAFSWRIPERYNIGADVCDRWADGSGRLALIDERDDGRVTRHTFDALKAASNRLANSFARLGVVRGER
VGIFIAQGVQTAVAHLAAYKAGAIAVPLFALFGAEALEFRLADSGAAALVTDRAGAAKIAPLRAALPALRTVYCIDDDSG
GVPEGCLSFEAALAAESDRYTPVDTLADDPAMIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQNGFPRRARAFWTPADW
AWIGGLLDVLLPAWHHGVTVVARRFEKFDGEAAFALLARHQVSHAFLPPTALKLMRGVARPRERHALRIESVASGGESLG
SELLEWGREAFGVTINEFYGQTECNVVLASCSALFAPRAGAIGKAAPGHCVMIVDAAGTPVPAGVEGNIGIRAPDPVMFL
GYWRNPAATREKFAGDVLLTGDRGVADEDGFIRFVGRDDDVITSAGYRIGPGPIEDCLLRHPAVRMAAVVGVPDAVRTEI
VKAFVVVQPGVEAGDALVRELQQHVRTRLAAHEYPRAIAFVESLPMTATGKIIRRALRDA

Sequences:

>Translated_540_residues
MLPEADDYPALLAAFSWRIPERYNIGADVCDRWADGSGRLALIDERDDGRVTRHTFDALKAASNRLANSFARLGVVRGER
VGIFIAQGVQTAVAHLAAYKAGAIAVPLFALFGAEALEFRLADSGAAALVTDRAGAAKIAPLRAALPALRTVYCIDDDSG
GVPEGCLSFEAALAAESDRYTPVDTLADDPAMIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQNGFPRRARAFWTPADW
AWIGGLLDVLLPAWHHGVTVVARRFEKFDGEAAFALLARHQVSHAFLPPTALKLMRGVARPRERHALRIESVASGGESLG
SELLEWGREAFGVTINEFYGQTECNVVLASCSALFAPRAGAIGKAAPGHCVMIVDAAGTPVPAGVEGNIGIRAPDPVMFL
GYWRNPAATREKFAGDVLLTGDRGVADEDGFIRFVGRDDDVITSAGYRIGPGPIEDCLLRHPAVRMAAVVGVPDAVRTEI
VKAFVVVQPGVEAGDALVRELQQHVRTRLAAHEYPRAIAFVESLPMTATGKIIRRALRDA
>Mature_540_residues
MLPEADDYPALLAAFSWRIPERYNIGADVCDRWADGSGRLALIDERDDGRVTRHTFDALKAASNRLANSFARLGVVRGER
VGIFIAQGVQTAVAHLAAYKAGAIAVPLFALFGAEALEFRLADSGAAALVTDRAGAAKIAPLRAALPALRTVYCIDDDSG
GVPEGCLSFEAALAAESDRYTPVDTLADDPAMIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQNGFPRRARAFWTPADW
AWIGGLLDVLLPAWHHGVTVVARRFEKFDGEAAFALLARHQVSHAFLPPTALKLMRGVARPRERHALRIESVASGGESLG
SELLEWGREAFGVTINEFYGQTECNVVLASCSALFAPRAGAIGKAAPGHCVMIVDAAGTPVPAGVEGNIGIRAPDPVMFL
GYWRNPAATREKFAGDVLLTGDRGVADEDGFIRFVGRDDDVITSAGYRIGPGPIEDCLLRHPAVRMAAVVGVPDAVRTEI
VKAFVVVQPGVEAGDALVRELQQHVRTRLAAHEYPRAIAFVESLPMTATGKIIRRALRDA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157311624, Length=546, Percent_Identity=33.8827838827839, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI157311622, Length=546, Percent_Identity=33.8827838827839, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI115511026, Length=547, Percent_Identity=32.9067641681901, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI58082049, Length=546, Percent_Identity=33.6996336996337, Blast_Score=272, Evalue=6e-73,
Organism=Homo sapiens, GI38505220, Length=542, Percent_Identity=32.1033210332103, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI42544132, Length=551, Percent_Identity=29.94555353902, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI122937307, Length=538, Percent_Identity=32.3420074349442, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI13375727, Length=565, Percent_Identity=29.5575221238938, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI28416953, Length=571, Percent_Identity=28.3712784588441, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI187761345, Length=554, Percent_Identity=27.6173285198556, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI187761343, Length=554, Percent_Identity=27.6173285198556, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI8923896, Length=580, Percent_Identity=26.7241379310345, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI253970489, Length=593, Percent_Identity=26.4755480607083, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI156151445, Length=544, Percent_Identity=25.9191176470588, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI195947378, Length=454, Percent_Identity=26.6519823788546, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI42544134, Length=385, Percent_Identity=22.3376623376623, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI38524616, Length=555, Percent_Identity=27.7477477477477, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=568, Percent_Identity=27.6408450704225, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788107, Length=559, Percent_Identity=27.3703041144902, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI221142682, Length=535, Percent_Identity=26.9158878504673, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1786529, Length=558, Percent_Identity=27.2401433691756, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI145693145, Length=511, Percent_Identity=27.2015655577299, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1786810, Length=533, Percent_Identity=26.6416510318949, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1786801, Length=582, Percent_Identity=25.2577319587629, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789201, Length=488, Percent_Identity=24.7950819672131, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=510, Percent_Identity=26.078431372549, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=495, Percent_Identity=25.8585858585859, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560140, Length=520, Percent_Identity=26.7307692307692, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=495, Percent_Identity=27.4747474747475, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983001, Length=532, Percent_Identity=25.7518796992481, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982997, Length=532, Percent_Identity=25.7518796992481, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17559526, Length=570, Percent_Identity=25.0877192982456, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=521, Percent_Identity=25.1439539347409, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71994694, Length=521, Percent_Identity=25.1439539347409, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71994690, Length=521, Percent_Identity=25.1439539347409, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=485, Percent_Identity=25.5670103092783, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=504, Percent_Identity=24.2063492063492, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560308, Length=525, Percent_Identity=24.952380952381, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=397, Percent_Identity=25.4408060453401, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17556552, Length=499, Percent_Identity=25.0501002004008, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323182, Length=576, Percent_Identity=28.125, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319264, Length=576, Percent_Identity=27.6041666666667, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319699, Length=502, Percent_Identity=26.6932270916335, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21355225, Length=544, Percent_Identity=27.5735294117647, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24667955, Length=538, Percent_Identity=25.6505576208178, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI62472339, Length=538, Percent_Identity=25.6505576208178, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922652, Length=498, Percent_Identity=26.3052208835341, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581924, Length=520, Percent_Identity=25.3846153846154, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=27.0216962524655, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24667959, Length=504, Percent_Identity=25.3968253968254, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18859661, Length=536, Percent_Identity=24.4402985074627, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=23.4285714285714, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130357, Length=357, Percent_Identity=26.3305322128852, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=389, Percent_Identity=23.1362467866324, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648260, Length=396, Percent_Identity=25.2525252525253, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653035, Length=357, Percent_Identity=24.6498599439776, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45550496, Length=555, Percent_Identity=24.1441441441441, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552801, Length=555, Percent_Identity=24.1441441441441, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281365686, Length=330, Percent_Identity=23.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161076582, Length=364, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648257, Length=422, Percent_Identity=25.1184834123223, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 57709; Mature: 57709

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEADDYPALLAAFSWRIPERYNIGADVCDRWADGSGRLALIDERDDGRVTRHTFDALK
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
AASNRLANSFARLGVVRGERVGIFIAQGVQTAVAHLAAYKAGAIAVPLFALFGAEALEFR
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHEEEE
LADSGAAALVTDRAGAAKIAPLRAALPALRTVYCIDDDSGGVPEGCLSFEAALAAESDRY
ECCCCCEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
TPVDTLADDPAMIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQNGFPRRARAFWTPADW
CCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCHH
AWIGGLLDVLLPAWHHGVTVVARRFEKFDGEAAFALLARHQVSHAFLPPTALKLMRGVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
PRERHALRIESVASGGESLGSELLEWGREAFGVTINEFYGQTECNVVLASCSALFAPRAG
CHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHEEHHHHHHCCCCC
AIGKAAPGHCVMIVDAAGTPVPAGVEGNIGIRAPDPVMFLGYWRNPAATREKFAGDVLLT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEEE
GDRGVADEDGFIRFVGRDDDVITSAGYRIGPGPIEDCLLRHPAVRMAAVVGVPDAVRTEI
CCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHH
VKAFVVVQPGVEAGDALVRELQQHVRTRLAAHEYPRAIAFVESLPMTATGKIIRRALRDA
HHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLPEADDYPALLAAFSWRIPERYNIGADVCDRWADGSGRLALIDERDDGRVTRHTFDALK
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
AASNRLANSFARLGVVRGERVGIFIAQGVQTAVAHLAAYKAGAIAVPLFALFGAEALEFR
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHEEEE
LADSGAAALVTDRAGAAKIAPLRAALPALRTVYCIDDDSGGVPEGCLSFEAALAAESDRY
ECCCCCEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
TPVDTLADDPAMIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQNGFPRRARAFWTPADW
CCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCHH
AWIGGLLDVLLPAWHHGVTVVARRFEKFDGEAAFALLARHQVSHAFLPPTALKLMRGVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
PRERHALRIESVASGGESLGSELLEWGREAFGVTINEFYGQTECNVVLASCSALFAPRAG
CHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHEEHHHHHHCCCCC
AIGKAAPGHCVMIVDAAGTPVPAGVEGNIGIRAPDPVMFLGYWRNPAATREKFAGDVLLT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEEE
GDRGVADEDGFIRFVGRDDDVITSAGYRIGPGPIEDCLLRHPAVRMAAVVGVPDAVRTEI
CCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHH
VKAFVVVQPGVEAGDALVRELQQHVRTRLAAHEYPRAIAFVESLPMTATGKIIRRALRDA
HHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]