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The map label for this gene is hbd [H]

Identifier: 238026756

GI number: 238026756

Start: 1224058

End: 1224978

Strand: Direct

Name: hbd [H]

Synonym: bglu_1g11140

Alternate gene names: 238026756

Gene position: 1224058-1224978 (Clockwise)

Preceding gene: 238026755

Following gene: 238026758

Centisome position: 31.33

GC content: 71.23

Gene sequence:

>921_bases
ATGGACATCCAACGAATCGCCGTGGTCGGCGCGGGCGTGATCGGCGCGAGCTGGGCCGCGTTTTATCTCGACCACGGCTT
CGAGGTCGTGGTCAGCGACCCGGCGCCCGATGCGCAAGCACGGCTGCAGGCTTCGCTCAGGCGCGTTCTCGGCGAGGCGC
GCCTGGGCGAACTCGCGCCGCGGCTGCGCTTTGCGGCCGAACTCGACGCCGCGCTGGACGGTGTCGAGTTCGTGCAGGAG
AACGGTCCCGAGCGGCTCGACCTCAAGCGCGAGCTGTATCGCGCGATGGACGCGCGACTGGGCGCCGAGGCCATCATCGC
CTCGAGTTTGTCGGGGCTCAAGATGTCGGCGATCCAGACCGCCTGCGAGCGCCACCCCGGGCGCTGCCTGATCGCGCATC
CGTTCAACCCGCCGCATCTGATTCCGCTCGTCGAGCTGGTGGGCGGCGAGGCCACCTCGCGCGACACGATCGAGCGCGCG
AAGCGCTTCTACGACGGCCTCGGCAAGGTCACGATCGTGCTCAACCGCGAGATGGCCGGCCACGTCGCGAACCGGCTCGC
CGCGGCGCTGTTCCGCGAGGTCTATCACCTGGTGGGCGAGGGCGTGGTCAGTGTGGCCGACGCCGACAAGGCCGTGTCGT
GGGGGCCGGGGCTGCGCTGGGGGCTGATGGGGCAGGCGCTGACCTATCACCTCGGCGGCGGCGACGGCGGCATCGAGCAT
TTCCTCGACCATCTGGCCGGGCCGATCACGAGCTGGTGGGACGATCTCGGCACGCCGTCGTTCGACGCACGCGTCGACCG
CCAGCTCGGCGACGAGCTGCGCGCGATCCAGGGCGCGCGCCCGATCGCCGAGTGGGGCGCCGAGCGCGACCGGCTGCTGG
CCGAACTGATCGAGGCGCGCCGCCGCAGCTTCCTGCCCTGA

Upstream 100 bases:

>100_bases
CGGTGGTGCGCCGCGCTGCGTGTGCCCGGCGGGCGATCGGACGCGTCCGTGTCGATCGATGCGACAATCGTCGCCGTTCA
TCGCTATCGGAGACGGGTTC

Downstream 100 bases:

>100_bases
GTGCGGCGCCGGCATCGAGCGGCCCGCGTTCAGCGGTGGAGCGCCGCGCGAGCCGGTTGCGCGCCCACCGCGCGCCCGCC
GCGCGCCCACCGCGGAGGCG

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MDIQRIAVVGAGVIGASWAAFYLDHGFEVVVSDPAPDAQARLQASLRRVLGEARLGELAPRLRFAAELDAALDGVEFVQE
NGPERLDLKRELYRAMDARLGAEAIIASSLSGLKMSAIQTACERHPGRCLIAHPFNPPHLIPLVELVGGEATSRDTIERA
KRFYDGLGKVTIVLNREMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVSWGPGLRWGLMGQALTYHLGGGDGGIEH
FLDHLAGPITSWWDDLGTPSFDARVDRQLGDELRAIQGARPIAEWGAERDRLLAELIEARRRSFLP

Sequences:

>Translated_306_residues
MDIQRIAVVGAGVIGASWAAFYLDHGFEVVVSDPAPDAQARLQASLRRVLGEARLGELAPRLRFAAELDAALDGVEFVQE
NGPERLDLKRELYRAMDARLGAEAIIASSLSGLKMSAIQTACERHPGRCLIAHPFNPPHLIPLVELVGGEATSRDTIERA
KRFYDGLGKVTIVLNREMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVSWGPGLRWGLMGQALTYHLGGGDGGIEH
FLDHLAGPITSWWDDLGTPSFDARVDRQLGDELRAIQGARPIAEWGAERDRLLAELIEARRRSFLP
>Mature_306_residues
MDIQRIAVVGAGVIGASWAAFYLDHGFEVVVSDPAPDAQARLQASLRRVLGEARLGELAPRLRFAAELDAALDGVEFVQE
NGPERLDLKRELYRAMDARLGAEAIIASSLSGLKMSAIQTACERHPGRCLIAHPFNPPHLIPLVELVGGEATSRDTIERA
KRFYDGLGKVTIVLNREMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVSWGPGLRWGLMGQALTYHLGGGDGGIEH
FLDHLAGPITSWWDDLGTPSFDARVDRQLGDELRAIQGARPIAEWGAERDRLLAELIEARRRSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=269, Percent_Identity=32.7137546468402, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI296179429, Length=235, Percent_Identity=28.936170212766, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI296179427, Length=240, Percent_Identity=27.5, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI20127408, Length=209, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790281, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=243, Percent_Identity=32.0987654320988, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193203623, Length=243, Percent_Identity=32.0987654320988, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508953, Length=210, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=215, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=210, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=22.707423580786, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549919, Length=233, Percent_Identity=24.0343347639485, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=215, Percent_Identity=26.5116279069767, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45549573, Length=304, Percent_Identity=29.6052631578947, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI20129993, Length=315, Percent_Identity=31.1111111111111, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583077, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583079, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921000, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33290; Mature: 33290

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQRIAVVGAGVIGASWAAFYLDHGFEVVVSDPAPDAQARLQASLRRVLGEARLGELAP
CCCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RLRFAAELDAALDGVEFVQENGPERLDLKRELYRAMDARLGAEAIIASSLSGLKMSAIQT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHH
ACERHPGRCLIAHPFNPPHLIPLVELVGGEATSRDTIERAKRFYDGLGKVTIVLNREMAG
HHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
HVANRLAAALFREVYHLVGEGVVSVADADKAVSWGPGLRWGLMGQALTYHLGGGDGGIEH
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCHHH
FLDHLAGPITSWWDDLGTPSFDARVDRQLGDELRAIQGARPIAEWGAERDRLLAELIEAR
HHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
RRSFLP
HHHCCC
>Mature Secondary Structure
MDIQRIAVVGAGVIGASWAAFYLDHGFEVVVSDPAPDAQARLQASLRRVLGEARLGELAP
CCCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RLRFAAELDAALDGVEFVQENGPERLDLKRELYRAMDARLGAEAIIASSLSGLKMSAIQT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHH
ACERHPGRCLIAHPFNPPHLIPLVELVGGEATSRDTIERAKRFYDGLGKVTIVLNREMAG
HHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
HVANRLAAALFREVYHLVGEGVVSVADADKAVSWGPGLRWGLMGQALTYHLGGGDGGIEH
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCHHH
FLDHLAGPITSWWDDLGTPSFDARVDRQLGDELRAIQGARPIAEWGAERDRLLAELIEAR
HHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
RRSFLP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]