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The map label for this gene is hisM [H]

Identifier: 238026654

GI number: 238026654

Start: 1085543

End: 1086256

Strand: Direct

Name: hisM [H]

Synonym: bglu_1g10070

Alternate gene names: 238026654

Gene position: 1085543-1086256 (Clockwise)

Preceding gene: 238026653

Following gene: 238026655

Centisome position: 27.79

GC content: 68.21

Gene sequence:

>714_bases
ATGATCGAGATCCTGCAGGAATTCGGCCGTGCGTTCCTCTACCACGACGGCCAGCGTTTCTCGGGCCTCGTGGTCACGCT
GTGGCTGCTGGCGGCGTCGATCGGCATCGGCTTCGTCTGCGCGGTGCCGCTCGCGGTGGCGCGCGTCTCGCGCAGGCGCT
GGCTGTGCGTGCCGGTGCGGCTCTACACCTACGTGTTTCGCGGCACGCCGCTCTACGTGCAACTGCTGCTGATCTACACC
GGCCTCTACAGCCTCGAGGTCGTGCGCTCGCACTCGCTGCTCGACGCGTTCTTCCGCAGCGGGTATCACTGTACGGTGCT
GGCCTTCGCGCTGAACACCTGCGCCTATACCACCGAGATCTTCGCCGGCGCGATCCGCGCCACGGCGCACGGCGAGGTCG
AGGCGGCGCGCGCCTACGGCATGGGCGGCTGGACCCTGTACCGGCGCGTGATCCTGCCCTCGGCACTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAGGTGATCCTGATGCTGCACGCCACCACGGTGGCGTTCACGGCCACCGTGCCCGACATCCTGAA
GGTCGCGCGCGACGCGAATTCGGCCACCTACCTGGCATTCCAGTCGTTCGGCGTGGCCGCGCTGCTCTATCTTGCGGTAT
CGTTCGCACTCGTCGCGGCGTTTCGCCGGGCCGAGCGCCATTGGCTCGCGTATCTCGCGGCCGGCCGTCATTGA

Upstream 100 bases:

>100_bases
TCGTCGCGGCGCTGGTCTATCTGGCGATCACGACGCTTTCCAACCTGGTGCTGCGGCAGCTGGAGCGGCGCTACTCGCTC
GGCGTGAGGCACGCGGAACT

Downstream 100 bases:

>100_bases
ATCGCCTTCATTTCCGGAGAGGCCAGTTGGCAGAGACCACGCAGCCGAACGCCGTCAGCAAGCTCGCGGCGCACGACATT
CACAAGCGCTACGGCGACAA

Product: histidine/lysine/arginine/ornithine ABC transporter permease HisM

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIEILQEFGRAFLYHDGQRFSGLVVTLWLLAASIGIGFVCAVPLAVARVSRRRWLCVPVRLYTYVFRGTPLYVQLLLIYT
GLYSLEVVRSHSLLDAFFRSGYHCTVLAFALNTCAYTTEIFAGAIRATAHGEVEAARAYGMGGWTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYLAFQSFGVAALLYLAVSFALVAAFRRAERHWLAYLAAGRH

Sequences:

>Translated_237_residues
MIEILQEFGRAFLYHDGQRFSGLVVTLWLLAASIGIGFVCAVPLAVARVSRRRWLCVPVRLYTYVFRGTPLYVQLLLIYT
GLYSLEVVRSHSLLDAFFRSGYHCTVLAFALNTCAYTTEIFAGAIRATAHGEVEAARAYGMGGWTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYLAFQSFGVAALLYLAVSFALVAAFRRAERHWLAYLAAGRH
>Mature_237_residues
MIEILQEFGRAFLYHDGQRFSGLVVTLWLLAASIGIGFVCAVPLAVARVSRRRWLCVPVRLYTYVFRGTPLYVQLLLIYT
GLYSLEVVRSHSLLDAFFRSGYHCTVLAFALNTCAYTTEIFAGAIRATAHGEVEAARAYGMGGWTLYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYLAFQSFGVAALLYLAVSFALVAAFRRAERHWLAYLAAGRH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=61.6379310344828, Blast_Score=301, Evalue=2e-83,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=32.7102803738318, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788226, Length=175, Percent_Identity=35.4285714285714, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787030, Length=208, Percent_Identity=29.3269230769231, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788646, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786873, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787087, Length=165, Percent_Identity=25.4545454545455, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26349; Mature: 26349

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQEFGRAFLYHDGQRFSGLVVTLWLLAASIGIGFVCAVPLAVARVSRRRWLCVPVR
CHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
LYTYVFRGTPLYVQLLLIYTGLYSLEVVRSHSLLDAFFRSGYHCTVLAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIRATAHGEVEAARAYGMGGWTLYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYLAFQSFGVAALLYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEILQEFGRAFLYHDGQRFSGLVVTLWLLAASIGIGFVCAVPLAVARVSRRRWLCVPVR
CHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
LYTYVFRGTPLYVQLLLIYTGLYSLEVVRSHSLLDAFFRSGYHCTVLAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIRATAHGEVEAARAYGMGGWTLYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYLAFQSFGVAALLYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]