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The map label for this gene is ytbQ [H]

Identifier: 238026643

GI number: 238026643

Start: 1069948

End: 1070790

Strand: Direct

Name: ytbQ [H]

Synonym: bglu_1g09950

Alternate gene names: 238026643

Gene position: 1069948-1070790 (Clockwise)

Preceding gene: 238026642

Following gene: 238026648

Centisome position: 27.39

GC content: 68.33

Gene sequence:

>843_bases
GTGACTTCGCCCACTTCCACGACCGCCAAGCCGTTCCGCCGCCTGCTGCTCACCGGCGCCGCGGGCAATCTCGGCCGCCA
GCTGCGCGCGGCGCTCGGCGATTGGGCCGACATCGTCCGCGTCAGCGACATCGCGCCGCTCGGCGAGGTGGCACCGCACG
AGGAAGCGGTGGTGGCGGACCTGGCCGACCGCGCCGCCGTCAACGCGCTGGTCGAGGGCGTGGACGCCGTGATCCACCTC
GGCGGCATCTCGGTGGACGCGCCGTTCGACGCGCTGATCGAGGCCAACATCCGCGGCGTCTACAACCTCTATGCGGCCGC
CCATCAGTTCGGCGTGCGCCGTATCGTCTACGCGAGCTCGAACCACGTGGTCGGTTTCCATCCGGTCACCGAGGTGGTCG
ACGTCGATTCGCCGCCGCGCCCCGATTCGCTGTACGGCGTGACGAAGTGCTTCGGCGAGTCGCTGTCGCGCTATTATTTC
GACCGCTTCGGCCTGGAGACGGTGTGCCTGCGGATCGGCTCGTCGTTCGACGTGCCCAAGAACCCGCGCATGCTGGTTAC
CTACCTGAGCTTCCGTGACTTCATCGAGCTGGTGCGCTGCTCGCTGATGACCAACCGGGTTGGCCACGCGATCGTCTACG
GCGTGTCGGACAACCGCACCAAGTGGATCGACAACGCCAAGGCCGCGTTCCTCGGCTTCCGCCCGCAGGACAGCTCGGCG
CCGTTCGAGCACCTGTTCCCGTCGAGCGGCCCGGACCGCAATCTCGACGATCCGGCACAGCGCTACCAGGGCGGCGGCTT
CGTGGTCGGCGAGCCGCAGGGCGAACCGAAGCTCACGAACTGA

Upstream 100 bases:

>100_bases
AAACGTCAGTCATCGTATAAGATCGCGATTCCGCGCCTCGATGCCTTTGCATCGGCGTCCTGCCACCTGCTTCGATTCGC
CATCCAGAGAGGATTTCGCC

Downstream 100 bases:

>100_bases
GCACACCCGAAACAGGCAATCCGCCGGCCGCGTGAGCGGCACGGCGGGGCGGGGCAGGGCGGCGAGCGCGAGAGCGCGCG
CGGCGCGAGAACCCCGCGGA

Product: 3-beta hydroxysteroid dehydrogenase/isomerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTSPTSTTAKPFRRLLLTGAAGNLGRQLRAALGDWADIVRVSDIAPLGEVAPHEEAVVADLADRAAVNALVEGVDAVIHL
GGISVDAPFDALIEANIRGVYNLYAAAHQFGVRRIVYASSNHVVGFHPVTEVVDVDSPPRPDSLYGVTKCFGESLSRYYF
DRFGLETVCLRIGSSFDVPKNPRMLVTYLSFRDFIELVRCSLMTNRVGHAIVYGVSDNRTKWIDNAKAAFLGFRPQDSSA
PFEHLFPSSGPDRNLDDPAQRYQGGGFVVGEPQGEPKLTN

Sequences:

>Translated_280_residues
MTSPTSTTAKPFRRLLLTGAAGNLGRQLRAALGDWADIVRVSDIAPLGEVAPHEEAVVADLADRAAVNALVEGVDAVIHL
GGISVDAPFDALIEANIRGVYNLYAAAHQFGVRRIVYASSNHVVGFHPVTEVVDVDSPPRPDSLYGVTKCFGESLSRYYF
DRFGLETVCLRIGSSFDVPKNPRMLVTYLSFRDFIELVRCSLMTNRVGHAIVYGVSDNRTKWIDNAKAAFLGFRPQDSSA
PFEHLFPSSGPDRNLDDPAQRYQGGGFVVGEPQGEPKLTN
>Mature_279_residues
TSPTSTTAKPFRRLLLTGAAGNLGRQLRAALGDWADIVRVSDIAPLGEVAPHEEAVVADLADRAAVNALVEGVDAVIHLG
GISVDAPFDALIEANIRGVYNLYAAAHQFGVRRIVYASSNHVVGFHPVTEVVDVDSPPRPDSLYGVTKCFGESLSRYYFD
RFGLETVCLRIGSSFDVPKNPRMLVTYLSFRDFIELVRCSLMTNRVGHAIVYGVSDNRTKWIDNAKAAFLGFRPQDSSAP
FEHLFPSSGPDRNLDDPAQRYQGGGFVVGEPQGEPKLTN

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 30465; Mature: 30334

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPTSTTAKPFRRLLLTGAAGNLGRQLRAALGDWADIVRVSDIAPLGEVAPHEEAVVAD
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LADRAAVNALVEGVDAVIHLGGISVDAPFDALIEANIRGVYNLYAAAHQFGVRRIVYASS
HHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
NHVVGFHPVTEVVDVDSPPRPDSLYGVTKCFGESLSRYYFDRFGLETVCLRIGSSFDVPK
CCEEEECCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NPRMLVTYLSFRDFIELVRCSLMTNRVGHAIVYGVSDNRTKWIDNAKAAFLGFRPQDSSA
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEEEECCCCCCCC
PFEHLFPSSGPDRNLDDPAQRYQGGGFVVGEPQGEPKLTN
CHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
TSPTSTTAKPFRRLLLTGAAGNLGRQLRAALGDWADIVRVSDIAPLGEVAPHEEAVVAD
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LADRAAVNALVEGVDAVIHLGGISVDAPFDALIEANIRGVYNLYAAAHQFGVRRIVYASS
HHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
NHVVGFHPVTEVVDVDSPPRPDSLYGVTKCFGESLSRYYFDRFGLETVCLRIGSSFDVPK
CCEEEECCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NPRMLVTYLSFRDFIELVRCSLMTNRVGHAIVYGVSDNRTKWIDNAKAAFLGFRPQDSSA
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEEEECCCCCCCC
PFEHLFPSSGPDRNLDDPAQRYQGGGFVVGEPQGEPKLTN
CHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]