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The map label for this gene is pntAA [H]

Identifier: 238025375

GI number: 238025375

Start: 2540064

End: 2541158

Strand: Reverse

Name: pntAA [H]

Synonym: bglu_2g20530

Alternate gene names: 238025375

Gene position: 2541158-2540064 (Counterclockwise)

Preceding gene: 238025376

Following gene: 238025374

Centisome position: 89.88

GC content: 66.21

Gene sequence:

>1095_bases
ATGGCTTTCAATATCTCGATTTTGAAGGAAACTCGGGCCGGAGAGTGCCGTGTCGCGCTCGTGCCGGTGGTTGCGTCGCG
TTTGCAGCGGCTTGGTGCACGGATATATATGGAATCCGGTGCCGGCATGAAAGCGAAATTCTTGAATGAGGATTACGAAC
AAGTCGATTTCGATTCGGATCGAATTCAGCTTGCCGCCCATGCGGATATCCTGCTCGCGGTGCAGCCGCCGCCGCTGGAG
GTCGTCAATGCGCTGAAGCCGGGCGCGGTGCTGATTTCGTTTTTGCAGGCGCCGCACGAGGCGGCCCTGATCGAGGCGCT
GCGCGCCCGGTGCGTCACCAGCTTCGCGATGGAGCGGATTCCGCGCATCAGCCGGGCACAGGCGATGGATGCGCTGTCGA
GCCAGGCGGCGCTGGCGGGCTATTACGCGCCGCTTCTCGGCGCCGTGCATCTGCCGCGCATCCTGCCGATGCTGACCACG
GCGGTCGGTTCGCTGCGCGCGGCGAAGGTGCTGGTGCTGGGGCTGGGCGTGGCGGGCCTGCAGGCGCTGGCTACCGCGCA
CCGGCTCGGCGCGGTGACCGAGGGCTACGACGTGCGGCCGGAGACGCGCGAGCAGGCGCTCTCCCTCGGCGCCAAGTTCG
TCGATACCGGGGTCGACGCGCGCGGCGAGGGCGGGTATGCGCGGGAGTTGTCCGAGGACGAACGGCAGCGCGTCGGCGCG
GTGCTGGACAAGCATATCGCCGAAGCCGACATGATCATCACCACCGCATCGGTGCCGGGGCGCCGCGCGCCCCGGCTCGT
GTCGCTCGCCCAGATCGAGAGGATGAAGCCAGGTGCCGTCATCGTCGACCTCGGCGCCGAAAACGGCGGCAACTGCGAGG
GCACGGTGGCGGGAGAAACGGTGGAAATCGGGCCGGTCACGATTCTCGGGCCCTGCAACGTGCCTTCCCTGCTCAGCCAG
CATGCCAGCGAACTCTATGCGAAGAACCTGTTGAATTTCGTCGGACTGCTGGTCAAGGACGGCGCGCTGCATATCGATTT
CGACGACGAAATCGTGGCCGGGACCGCCGTCACGCATGACGGCGCCGTTCGCTAG

Upstream 100 bases:

>100_bases
ATTTACTTGATCGCCGTCAATTCCCATCGAGCGGGCTCGAAGATTTGAATTAGTAATGAAATGATCGCCTGATAAATTCA
CCAAAAACCACGGTGATTTT

Downstream 100 bases:

>100_bases
CGCCCCTTCCCCTCGCCAGGCCTGCCATCACGTTATCGCTTGATCCGGGAATCATCGTGACACTGATAATCGCGCTTTAC
ATTTTCATGCTCGCCGCTTT

Product: NAD(P) transhydrogenase subunit alpha-1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAFNISILKETRAGECRVALVPVVASRLQRLGARIYMESGAGMKAKFLNEDYEQVDFDSDRIQLAAHADILLAVQPPPLE
VVNALKPGAVLISFLQAPHEAALIEALRARCVTSFAMERIPRISRAQAMDALSSQAALAGYYAPLLGAVHLPRILPMLTT
AVGSLRAAKVLVLGLGVAGLQALATAHRLGAVTEGYDVRPETREQALSLGAKFVDTGVDARGEGGYARELSEDERQRVGA
VLDKHIAEADMIITTASVPGRRAPRLVSLAQIERMKPGAVIVDLGAENGGNCEGTVAGETVEIGPVTILGPCNVPSLLSQ
HASELYAKNLLNFVGLLVKDGALHIDFDDEIVAGTAVTHDGAVR

Sequences:

>Translated_364_residues
MAFNISILKETRAGECRVALVPVVASRLQRLGARIYMESGAGMKAKFLNEDYEQVDFDSDRIQLAAHADILLAVQPPPLE
VVNALKPGAVLISFLQAPHEAALIEALRARCVTSFAMERIPRISRAQAMDALSSQAALAGYYAPLLGAVHLPRILPMLTT
AVGSLRAAKVLVLGLGVAGLQALATAHRLGAVTEGYDVRPETREQALSLGAKFVDTGVDARGEGGYARELSEDERQRVGA
VLDKHIAEADMIITTASVPGRRAPRLVSLAQIERMKPGAVIVDLGAENGGNCEGTVAGETVEIGPVTILGPCNVPSLLSQ
HASELYAKNLLNFVGLLVKDGALHIDFDDEIVAGTAVTHDGAVR
>Mature_363_residues
AFNISILKETRAGECRVALVPVVASRLQRLGARIYMESGAGMKAKFLNEDYEQVDFDSDRIQLAAHADILLAVQPPPLEV
VNALKPGAVLISFLQAPHEAALIEALRARCVTSFAMERIPRISRAQAMDALSSQAALAGYYAPLLGAVHLPRILPMLTTA
VGSLRAAKVLVLGLGVAGLQALATAHRLGAVTEGYDVRPETREQALSLGAKFVDTGVDARGEGGYARELSEDERQRVGAV
LDKHIAEADMIITTASVPGRRAPRLVSLAQIERMKPGAVIVDLGAENGGNCEGTVAGETVEIGPVTILGPCNVPSLLSQH
ASELYAKNLLNFVGLLVKDGALHIDFDDEIVAGTAVTHDGAVR

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=378, Percent_Identity=34.3915343915344, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI122939153, Length=378, Percent_Identity=34.3915343915344, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787887, Length=365, Percent_Identity=39.4520547945205, Blast_Score=244, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17550456, Length=364, Percent_Identity=39.8351648351648, Blast_Score=251, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38516; Mature: 38385

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNISILKETRAGECRVALVPVVASRLQRLGARIYMESGAGMKAKFLNEDYEQVDFDSD
CEEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEEHHHCCCHHHCCCCCC
RIQLAAHADILLAVQPPPLEVVNALKPGAVLISFLQAPHEAALIEALRARCVTSFAMERI
CEEEEEECEEEEEECCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
PRISRAQAMDALSSQAALAGYYAPLLGAVHLPRILPMLTTAVGSLRAAKVLVLGLGVAGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QALATAHRLGAVTEGYDVRPETREQALSLGAKFVDTGVDARGEGGYARELSEDERQRVGA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCCCCCHHHCCHHHHHHHHH
VLDKHIAEADMIITTASVPGRRAPRLVSLAQIERMKPGAVIVDLGAENGGNCEGTVAGET
HHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
VEIGPVTILGPCNVPSLLSQHASELYAKNLLNFVGLLVKDGALHIDFDDEIVAGTAVTHD
EEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECEEECCC
GAVR
CCCC
>Mature Secondary Structure 
AFNISILKETRAGECRVALVPVVASRLQRLGARIYMESGAGMKAKFLNEDYEQVDFDSD
EEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEEHHHCCCHHHCCCCCC
RIQLAAHADILLAVQPPPLEVVNALKPGAVLISFLQAPHEAALIEALRARCVTSFAMERI
CEEEEEECEEEEEECCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
PRISRAQAMDALSSQAALAGYYAPLLGAVHLPRILPMLTTAVGSLRAAKVLVLGLGVAGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QALATAHRLGAVTEGYDVRPETREQALSLGAKFVDTGVDARGEGGYARELSEDERQRVGA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCCCCCHHHCCHHHHHHHHH
VLDKHIAEADMIITTASVPGRRAPRLVSLAQIERMKPGAVIVDLGAENGGNCEGTVAGET
HHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
VEIGPVTILGPCNVPSLLSQHASELYAKNLLNFVGLLVKDGALHIDFDDEIVAGTAVTHD
EEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECEEECCC
GAVR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]