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The map label for this gene is adhA [H]

Identifier: 238025362

GI number: 238025362

Start: 2525203

End: 2526192

Strand: Reverse

Name: adhA [H]

Synonym: bglu_2g20380

Alternate gene names: 238025362

Gene position: 2526192-2525203 (Counterclockwise)

Preceding gene: 238025365

Following gene: 238025361

Centisome position: 89.35

GC content: 72.42

Gene sequence:

>990_bases
ATGCTTGCGATGCAATTCGACGGCACGCGGCCGAGCCTGCGCGAGGTGCGCGTGCCCGACCCGCGGCCGGCAGCGGGGCA
GTTGCTCCTCGACGTGCGCGCCTGCGGCGTCTGCCGCACCGATCTGCACATCATCGACGGCGAACTGGCGGATCCGAAGC
GGCCGCTGATTCCCGGGCATGAAATCGTCGGCACGGTGAGCGCGCTGGGCGAGGGCGTGACCGGGTTCGCCGTCGGCGAG
CGGGTCGGCGTGCCATGGCTCGGCCAGACCTGTGGCGTGTGCCCCTATTGCCGCTCGGCACGGGAAAATCTGTGCGATGC
GCCGCGCTTCACCGGCTATACGATCGACGGCGGCTACGCCGAGCGCGCCGTCGCCGACCATCGCTACTGCGTCCATCTGC
CGGCGCGCTATTCCGACCTGGAGGCCGCGCCGCTGCTCTGTGCCGGCCTGATCGGCTATCGCAGCCTGCGCATGGCGGGC
GATGCGCGGCGCATCGGCATCTACGGGTTCGGCGCGGCGGCCCACCTGGTCTGCCAGATCGCCCGGGCCGAGGGGCGGCG
GGTGTTCGCCCTCGTCCGGCCCGGCGATCTGGCCGCCAGGCGGCTGGCCTTGTCGCTCGGCGCGGTGTGGGCGGGCGGCA
GCGACGAGGCGCCGCCGGAGCCGCTCGACGCCGCGCTGATCTTCGCCCCCGTGGGCGCCTTGATTCCGACCGCGCTGCGC
ATGCTCGTCAAGGGCGGAATCGTGGTGTGCGGCGGGATCCACATGAGCGAGATCCCGGCGTTTCCCTATGCCTTGCTGTG
GGGCGAGCGCCGTCTCGCCTCGGTCGCCAATCTGACCCGCGCGGATGCCGTCGCGTTCATGCGCACCGCCGAGGCGATAC
CGCTGCGCGTGCAGGCCTCGGCCTACCGCCTGAGCGATGCGAATCGCGCGCTCGACGATCTGCGCCAGGGGCGGGTGTCG
GGCGCAGCCGTGCTGACCCTGCCGGGCTGA

Upstream 100 bases:

>100_bases
ATGTCAAGCGCGCGACGGGATGCCATCCGTGCCGGCTTGCCAGCGTCTAGGCTTGAACCGGATTGGGCGCGGCACCGAGG
TTCGCGCGGGAGGGAGTGAC

Downstream 100 bases:

>100_bases
CCGGCGGTTCGGCGGACGCGCCCGGCGGTGCGCCGATCTGGCCGGGGGGCGGGCGCGACCGTGCCCGCCCGCAACGGGCG
CCTCCCCGCCGCCTGTCGGC

Product: zinc-binding alcohol dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MLAMQFDGTRPSLREVRVPDPRPAAGQLLLDVRACGVCRTDLHIIDGELADPKRPLIPGHEIVGTVSALGEGVTGFAVGE
RVGVPWLGQTCGVCPYCRSARENLCDAPRFTGYTIDGGYAERAVADHRYCVHLPARYSDLEAAPLLCAGLIGYRSLRMAG
DARRIGIYGFGAAAHLVCQIARAEGRRVFALVRPGDLAARRLALSLGAVWAGGSDEAPPEPLDAALIFAPVGALIPTALR
MLVKGGIVVCGGIHMSEIPAFPYALLWGERRLASVANLTRADAVAFMRTAEAIPLRVQASAYRLSDANRALDDLRQGRVS
GAAVLTLPG

Sequences:

>Translated_329_residues
MLAMQFDGTRPSLREVRVPDPRPAAGQLLLDVRACGVCRTDLHIIDGELADPKRPLIPGHEIVGTVSALGEGVTGFAVGE
RVGVPWLGQTCGVCPYCRSARENLCDAPRFTGYTIDGGYAERAVADHRYCVHLPARYSDLEAAPLLCAGLIGYRSLRMAG
DARRIGIYGFGAAAHLVCQIARAEGRRVFALVRPGDLAARRLALSLGAVWAGGSDEAPPEPLDAALIFAPVGALIPTALR
MLVKGGIVVCGGIHMSEIPAFPYALLWGERRLASVANLTRADAVAFMRTAEAIPLRVQASAYRLSDANRALDDLRQGRVS
GAAVLTLPG
>Mature_329_residues
MLAMQFDGTRPSLREVRVPDPRPAAGQLLLDVRACGVCRTDLHIIDGELADPKRPLIPGHEIVGTVSALGEGVTGFAVGE
RVGVPWLGQTCGVCPYCRSARENLCDAPRFTGYTIDGGYAERAVADHRYCVHLPARYSDLEAAPLLCAGLIGYRSLRMAG
DARRIGIYGFGAAAHLVCQIARAEGRRVFALVRPGDLAARRLALSLGAVWAGGSDEAPPEPLDAALIFAPVGALIPTALR
MLVKGGIVVCGGIHMSEIPAFPYALLWGERRLASVANLTRADAVAFMRTAEAIPLRVQASAYRLSDANRALDDLRQGRVS
GAAVLTLPG

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=94, Percent_Identity=38.2978723404255, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI71743840, Length=101, Percent_Identity=37.6237623762376, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073058, Length=101, Percent_Identity=37.6237623762376, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=94, Percent_Identity=37.2340425531915, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081918, Length=155, Percent_Identity=36.1290322580645, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87082401, Length=325, Percent_Identity=28.6153846153846, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786518, Length=199, Percent_Identity=36.1809045226131, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787863, Length=203, Percent_Identity=30.5418719211823, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=220, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI226510992, Length=102, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788073, Length=261, Percent_Identity=25.6704980842912, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=161, Percent_Identity=31.6770186335404, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=24.024024024024, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=212, Percent_Identity=29.2452830188679, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=30.6666666666667, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=131, Percent_Identity=34.3511450381679, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=125, Percent_Identity=32, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=202, Percent_Identity=29.2079207920792, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=211, Percent_Identity=36.0189573459716, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=192, Percent_Identity=36.9791666666667, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=211, Percent_Identity=36.9668246445498, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=192, Percent_Identity=35.9375, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323980, Length=200, Percent_Identity=33.5, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=201, Percent_Identity=31.8407960199005, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=214, Percent_Identity=27.1028037383178, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737895, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737897, Length=153, Percent_Identity=32.6797385620915, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34898; Mature: 34898

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMQFDGTRPSLREVRVPDPRPAAGQLLLDVRACGVCRTDLHIIDGELADPKRPLIPGH
CEEEECCCCCCCHHCCCCCCCCCCHHHEEEEHHHCCEEECCCEEECCCCCCCCCCCCCCH
EIVGTVSALGEGVTGFAVGERVGVPWLGQTCGVCPYCRSARENLCDAPRFTGYTIDGGYA
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCHH
ERAVADHRYCVHLPARYSDLEAAPLLCAGLIGYRSLRMAGDARRIGIYGFGAAAHLVCQI
HHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
ARAEGRRVFALVRPGDLAARRLALSLGAVWAGGSDEAPPEPLDAALIFAPVGALIPTALR
HHCCCCEEEEEECCCHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MLVKGGIVVCGGIHMSEIPAFPYALLWGERRLASVANLTRADAVAFMRTAEAIPLRVQAS
HHHHCCEEEECCCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
AYRLSDANRALDDLRQGRVSGAAVLTLPG
CEECCHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MLAMQFDGTRPSLREVRVPDPRPAAGQLLLDVRACGVCRTDLHIIDGELADPKRPLIPGH
CEEEECCCCCCCHHCCCCCCCCCCHHHEEEEHHHCCEEECCCEEECCCCCCCCCCCCCCH
EIVGTVSALGEGVTGFAVGERVGVPWLGQTCGVCPYCRSARENLCDAPRFTGYTIDGGYA
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCHH
ERAVADHRYCVHLPARYSDLEAAPLLCAGLIGYRSLRMAGDARRIGIYGFGAAAHLVCQI
HHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
ARAEGRRVFALVRPGDLAARRLALSLGAVWAGGSDEAPPEPLDAALIFAPVGALIPTALR
HHCCCCEEEEEECCCHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MLVKGGIVVCGGIHMSEIPAFPYALLWGERRLASVANLTRADAVAFMRTAEAIPLRVQAS
HHHHCCEEEECCCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
AYRLSDANRALDDLRQGRVSGAAVLTLPG
CEECCHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]