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The map label for this gene is 238025190

Identifier: 238025190

GI number: 238025190

Start: 2318810

End: 2320147

Strand: Reverse

Name: 238025190

Synonym: bglu_2g18610

Alternate gene names: NA

Gene position: 2320147-2318810 (Counterclockwise)

Preceding gene: 238025191

Following gene: 238025189

Centisome position: 82.06

GC content: 71.82

Gene sequence:

>1338_bases
ATGACGCCCGTCACCGATCTCGACGCGACGCGCTCGCCCGCGCTGCGCAGCTGGCTGGACAGCGCCAACCACGCGGCCTG
CGATTTCCCGATCCAGAACCTGCCGTTCGGCATCTTCGGCACCGCGGGCCGCGCCGCGCCGCGCGCCGGCGTGGCGCTCG
GCGAGAGCATCGCCGATCTGGCGGTGCTGGCCGAGGCCGGCTTGCTCGCCGTGCCCGGCGCCGACGCGCGCGAGCTGTTC
GCGCAGCCCACCCTGAACGCGTTCATCGCGCTCGGGCGCGAGGCATGGCGCGCGGTGCGCGTGCAGCTGAGCGCGCTGTT
CGCGCGTGACAACGCGCGGCTGCGCGACGACGCCGCGCTGCGCGAGGCGGTACTCGTGCCGCAGGCCGGCGCCACGCTGC
ACCTGCCGGTGGAGATCCCCGGCTACACGGACTTCTATTCGTCGAAGGAGCATGCGACCAACGTCGGCATGATGTTTCGC
GATCCGAAGCATGCGCTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGGCGCGCCTCGTCGGTGGTGGTGAG
CGGCACGCCGGTGCGCCGGCCGCGCGGCCAGCTCAAGCTGCCCGAGCGCGAGCGGCCGGTGTTCGGCGCGAGCCGGCGGC
TCGACCTCGAACTCGAGACGGGCTTCATCGTCGGGCGCGGCAACGCGCTGGGCGAGCCGATCGCGTGCGAGGCCGCGGAG
GCGCACATCTTCGGCATGGTGCTGCTCAACGACTGGAGCGCACGCGACATCCAGCAATGGGAATACGTGCCGCTCGGGCC
GTTCAACGCGAAGGGCTTCGCCACCACCATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAGCCGTTTCGCGTGGCGC
AGCCGAAGCAGGACCCGCTGCCGCTGCCATACCTGCGCCACGCCGGCGCGCACGGCTTCGACATCGAGCTCGAAGCGACA
CTGCAGCCGCACGGCGCGGCCGAGGCCACCACTCTCACGCGCACCAGCTTCCGGCACATGTACTGGACCATGGCGCAGCA
ACTCGCGCATCACACCGTGTCGGGCTGCAACACGCGGGTGGGCGACCTGATGGGCTCGGGCACCGTCAGCGGGCCGGGCA
AGGGCGCCTGCGGCAGCCTGCTGGAACTGACCTGGGGCGGCAAGGAGCCGATCGCGCTGGCGGGCGGCGGCACGCGCACC
TTCATCGAGGACGGCGATACCCTGACGCTGCGCGGCCACTGCCGCGGCGACGGCTATCGCATCGGCTTCGGCAGCTGTGT
CGGCACCATCCTGCCGGCACTGGCCGATACCGCGGAAGACGGGGCGCGCGATGACTGA

Upstream 100 bases:

>100_bases
TGCTGCGGCCCACCCGCTTCGCGCTGGGCGGCCCGCAGCGGCAGGCCGATTACGCGCGCTGCTGGCAGGGGCTCGCCAAA
CATTTCAACCCGGAGCAACG

Downstream 100 bases:

>100_bases
GGCCACGCTCTACGGCTATTTCCGCAGCTCGGCGTCGTACCGCGTGCGCATCGCGCTGAACCTGAAGGGCATCGACTACC
GGCAGATTCCCGTGCATCTG

Product: Fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTPVTDLDATRSPALRSWLDSANHAACDFPIQNLPFGIFGTAGRAAPRAGVALGESIADLAVLAEAGLLAVPGADARELF
AQPTLNAFIALGREAWRAVRVQLSALFARDNARLRDDAALREAVLVPQAGATLHLPVEIPGYTDFYSSKEHATNVGMMFR
DPKHALLPNWSEMPIGYNGRASSVVVSGTPVRRPRGQLKLPERERPVFGASRRLDLELETGFIVGRGNALGEPIACEAAE
AHIFGMVLLNDWSARDIQQWEYVPLGPFNAKGFATTISPWIVTLDALEPFRVAQPKQDPLPLPYLRHAGAHGFDIELEAT
LQPHGAAEATTLTRTSFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTVSGPGKGACGSLLELTWGGKEPIALAGGGTRT
FIEDGDTLTLRGHCRGDGYRIGFGSCVGTILPALADTAEDGARDD

Sequences:

>Translated_445_residues
MTPVTDLDATRSPALRSWLDSANHAACDFPIQNLPFGIFGTAGRAAPRAGVALGESIADLAVLAEAGLLAVPGADARELF
AQPTLNAFIALGREAWRAVRVQLSALFARDNARLRDDAALREAVLVPQAGATLHLPVEIPGYTDFYSSKEHATNVGMMFR
DPKHALLPNWSEMPIGYNGRASSVVVSGTPVRRPRGQLKLPERERPVFGASRRLDLELETGFIVGRGNALGEPIACEAAE
AHIFGMVLLNDWSARDIQQWEYVPLGPFNAKGFATTISPWIVTLDALEPFRVAQPKQDPLPLPYLRHAGAHGFDIELEAT
LQPHGAAEATTLTRTSFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTVSGPGKGACGSLLELTWGGKEPIALAGGGTRT
FIEDGDTLTLRGHCRGDGYRIGFGSCVGTILPALADTAEDGARDD
>Mature_444_residues
TPVTDLDATRSPALRSWLDSANHAACDFPIQNLPFGIFGTAGRAAPRAGVALGESIADLAVLAEAGLLAVPGADARELFA
QPTLNAFIALGREAWRAVRVQLSALFARDNARLRDDAALREAVLVPQAGATLHLPVEIPGYTDFYSSKEHATNVGMMFRD
PKHALLPNWSEMPIGYNGRASSVVVSGTPVRRPRGQLKLPERERPVFGASRRLDLELETGFIVGRGNALGEPIACEAAEA
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKGFATTISPWIVTLDALEPFRVAQPKQDPLPLPYLRHAGAHGFDIELEATL
QPHGAAEATTLTRTSFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTVSGPGKGACGSLLELTWGGKEPIALAGGGTRTF
IEDGDTLTLRGHCRGDGYRIGFGSCVGTILPALADTAEDGARDD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=408, Percent_Identity=57.1078431372549, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568863, Length=408, Percent_Identity=53.921568627451, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24657182, Length=407, Percent_Identity=51.3513513513513, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47631; Mature: 47499

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVTDLDATRSPALRSWLDSANHAACDFPIQNLPFGIFGTAGRAAPRAGVALGESIADL
CCCCCCCCCCCCHHHHHHHHCCCCCEECCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
AVLAEAGLLAVPGADARELFAQPTLNAFIALGREAWRAVRVQLSALFARDNARLRDDAAL
HHHHHCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
REAVLVPQAGATLHLPVEIPGYTDFYSSKEHATNVGMMFRDPKHALLPNWSEMPIGYNGR
HHEEECCCCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEECCCHHHCCCCCCCCCCCCCC
ASSVVVSGTPVRRPRGQLKLPERERPVFGASRRLDLELETGFIVGRGNALGEPIACEAAE
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCC
AHIFGMVLLNDWSARDIQQWEYVPLGPFNAKGFATTISPWIVTLDALEPFRVAQPKQDPL
CEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHCCCCCCCCC
PLPYLRHAGAHGFDIELEATLQPHGAAEATTLTRTSFRHMYWTMAQQLAHHTVSGCNTRV
CCCHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GDLMGSGTVSGPGKGACGSLLELTWGGKEPIALAGGGTRTFIEDGDTLTLRGHCRGDGYR
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCCEEEEEEEECCCCEE
IGFGSCVGTILPALADTAEDGARDD
EEHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TPVTDLDATRSPALRSWLDSANHAACDFPIQNLPFGIFGTAGRAAPRAGVALGESIADL
CCCCCCCCCCCHHHHHHHHCCCCCEECCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
AVLAEAGLLAVPGADARELFAQPTLNAFIALGREAWRAVRVQLSALFARDNARLRDDAAL
HHHHHCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
REAVLVPQAGATLHLPVEIPGYTDFYSSKEHATNVGMMFRDPKHALLPNWSEMPIGYNGR
HHEEECCCCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEECCCHHHCCCCCCCCCCCCCC
ASSVVVSGTPVRRPRGQLKLPERERPVFGASRRLDLELETGFIVGRGNALGEPIACEAAE
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCC
AHIFGMVLLNDWSARDIQQWEYVPLGPFNAKGFATTISPWIVTLDALEPFRVAQPKQDPL
CEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHCCCCCCCCC
PLPYLRHAGAHGFDIELEATLQPHGAAEATTLTRTSFRHMYWTMAQQLAHHTVSGCNTRV
CCCHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GDLMGSGTVSGPGKGACGSLLELTWGGKEPIALAGGGTRTFIEDGDTLTLRGHCRGDGYR
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCCEEEEEEEECCCCEE
IGFGSCVGTILPALADTAEDGARDD
EEHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA