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The map label for this gene is lysP [H]

Identifier: 238025064

GI number: 238025064

Start: 2158563

End: 2160098

Strand: Reverse

Name: lysP [H]

Synonym: bglu_2g17200

Alternate gene names: 238025064

Gene position: 2160098-2158563 (Counterclockwise)

Preceding gene: 238025068

Following gene: 238025063

Centisome position: 76.4

GC content: 66.93

Gene sequence:

>1536_bases
ATGTCATTACAAGATCCGAATTCCGAGCACACCGCCACCGCTTCTCCGCACCTCAAGCGCAGCCTCAAGGCCCGCCATCT
GACGATGATCGCGATCGGCGGCTCGATCGGCACGGGCCTGTTCGTGGCCTCGGGCGCATCGATCTCGCAGGCCGGCCCCG
GCGGCGCGATGCTCGCCTATCTGCTGATCGGCCTGATGGTCTACTGCCTGATGACGAGCCTCGGCGAGATGGCCGCGTTC
ATGCCGGTGTCCGGCTCGTTCGCCACCTACGGCGCCAAATACGTCGAGGAGGGATTCGGCTTCGCGCTCGGCTGGAACTA
CTGGTACAACTGGGCCGTGACGATCGCGGTGGAACTGGTGGCCGCGCAGCTCGTGATGGGCTACTGGTTTCCGCACGTAC
CCGGCGTGTGGTGGAGCGCGGCGTTTCTCGCCGTGATGTTCCTGCTCAACGCGCTGACCGTGCGCGGCTTCGGCGAGGCC
GAATACTGGTTCGCGCTGATCAAGGTGGTGACCGTGGTGGCGTTCATCGGCATCGGCCTGCTGATGATCTTCGGCATCCT
CACGGGTGGCCCGACGCCGGCGTGGCGCAACTTCACGGTCGGCGACGCACCGTTCGCGGGCGGCCTGCCGGCCATGATGG
GGGTGGCGATGATCGCCGGCTTCTCGTTCCAGGGCACCGAGCTGATCGGTATCGCCGCCGGCGAATCGGAGAACCCGCAC
ACCACGATTCCGCGCGCGGTGCGGCAGGTGTTCTGGCGCATCCTGCTGTTCTACGTGCTGGCGATCTTCGTGATCGGCAT
GCTGGTGCCGTACACCGATCCGAGCCTGCTCAAGAGCGACGTGACCGACGTGGGCGTGAGCCCGTTTGCGCTGGTGTTCC
GCCATGCCGGCCTCGCGTTCGCGGCCGGCGTGATGAACGCGGTGATCCTCACGGCGGTGCTGTCGGCCGGCAATTCGGGC
ATGTACGCGTCCACGCGGATGCTCTACGACCTCGCCAGGGAAGGCCGCGCGCCGCGCGTCTTCGCCCGGCTCTCGAAGGG
CGGCGTGCCGCGCAACGCCCTGATCGCGACCACGGCGGTGGGCGCGCTTTGCTTCCTGTCGTCGCGGTTCGGCGACAAGA
CCGTCTACCTGTGGCTCCTGAACACCTCGGGCATGACGGGCTTCATCGCCTGGCTCGGCATCGCGGTCAGCCACTACCGG
TTTCGGCGCGGCTTCGTGAAGCAGGGCTTCGCGCTGTCGCGGCTGCCGTATCGCTCGCGCCTGTTTCCCTACGGGCCGAT
CTTCGCGTTCGTGCTCTGCCTGGTGATCGCGCTGGGGCAGGACTACCAGGCATTCCTCTCGAACCGGATCGACTGGGTCG
GCGTGCTGGCCACCTACATCGGCATCCCGCTGTTCCTGGTCGTCTGGCTCGGTTATCGCGTCACGCATCGCGGCAGCCGC
CTGGTGCGCTACGAGGACATGGAAATCGCGCCGTGGCTCGACGACGACACGCGCCGCGAGGCACGCCAGATCAAGCAGCA
AGCGGAGACGGCGTGA

Upstream 100 bases:

>100_bases
CGCCAGACGCGCCGGCACCGGTTCGCGGTCACGCCGCCCGACCCGGGCGGCCCACGGCACGCGCGACCGATGCCGCCAGC
CCGCCCTCAGCCCGTCCGTC

Downstream 100 bases:

>100_bases
GCGCCGTCGCGCTGCCCGGCCCGCTGCGGCGGCCGCGCAGCGCGTGCGGGACGTGACCCCTGGCCTGGCCCGGAGCCGGC
CGATCGCCCCGGTTTTCCCG

Product: Lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSLQDPNSEHTATASPHLKRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMTSLGEMAAF
MPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMGYWFPHVPGVWWSAAFLAVMFLLNALTVRGFGEA
EYWFALIKVVTVVAFIGIGLLMIFGILTGGPTPAWRNFTVGDAPFAGGLPAMMGVAMIAGFSFQGTELIGIAAGESENPH
TTIPRAVRQVFWRILLFYVLAIFVIGMLVPYTDPSLLKSDVTDVGVSPFALVFRHAGLAFAAGVMNAVILTAVLSAGNSG
MYASTRMLYDLAREGRAPRVFARLSKGGVPRNALIATTAVGALCFLSSRFGDKTVYLWLLNTSGMTGFIAWLGIAVSHYR
FRRGFVKQGFALSRLPYRSRLFPYGPIFAFVLCLVIALGQDYQAFLSNRIDWVGVLATYIGIPLFLVVWLGYRVTHRGSR
LVRYEDMEIAPWLDDDTRREARQIKQQAETA

Sequences:

>Translated_511_residues
MSLQDPNSEHTATASPHLKRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMTSLGEMAAF
MPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMGYWFPHVPGVWWSAAFLAVMFLLNALTVRGFGEA
EYWFALIKVVTVVAFIGIGLLMIFGILTGGPTPAWRNFTVGDAPFAGGLPAMMGVAMIAGFSFQGTELIGIAAGESENPH
TTIPRAVRQVFWRILLFYVLAIFVIGMLVPYTDPSLLKSDVTDVGVSPFALVFRHAGLAFAAGVMNAVILTAVLSAGNSG
MYASTRMLYDLAREGRAPRVFARLSKGGVPRNALIATTAVGALCFLSSRFGDKTVYLWLLNTSGMTGFIAWLGIAVSHYR
FRRGFVKQGFALSRLPYRSRLFPYGPIFAFVLCLVIALGQDYQAFLSNRIDWVGVLATYIGIPLFLVVWLGYRVTHRGSR
LVRYEDMEIAPWLDDDTRREARQIKQQAETA
>Mature_510_residues
SLQDPNSEHTATASPHLKRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMTSLGEMAAFM
PVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMGYWFPHVPGVWWSAAFLAVMFLLNALTVRGFGEAE
YWFALIKVVTVVAFIGIGLLMIFGILTGGPTPAWRNFTVGDAPFAGGLPAMMGVAMIAGFSFQGTELIGIAAGESENPHT
TIPRAVRQVFWRILLFYVLAIFVIGMLVPYTDPSLLKSDVTDVGVSPFALVFRHAGLAFAAGVMNAVILTAVLSAGNSGM
YASTRMLYDLAREGRAPRVFARLSKGGVPRNALIATTAVGALCFLSSRFGDKTVYLWLLNTSGMTGFIAWLGIAVSHYRF
RRGFVKQGFALSRLPYRSRLFPYGPIFAFVLCLVIALGQDYQAFLSNRIDWVGVLATYIGIPLFLVVWLGYRVTHRGSRL
VRYEDMEIAPWLDDDTRREARQIKQQAETA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=353, Percent_Identity=23.7960339943343, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=74.012474012474, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=485, Percent_Identity=41.2371134020619, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI48994972, Length=434, Percent_Identity=38.7096774193548, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=38.9021479713604, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1786302, Length=413, Percent_Identity=39.9515738498789, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=34.3825665859564, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=517, Percent_Identity=32.495164410058, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1790653, Length=350, Percent_Identity=37.7142857142857, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=34.9489795918367, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87081869, Length=413, Percent_Identity=23.0024213075061, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082250, Length=378, Percent_Identity=24.6031746031746, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082023, Length=286, Percent_Identity=24.4755244755245, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324061, Length=512, Percent_Identity=36.71875, Blast_Score=349, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6320772, Length=517, Percent_Identity=36.3636363636364, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6324059, Length=513, Percent_Identity=36.4522417153996, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=527, Percent_Identity=32.4478178368121, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6322892, Length=511, Percent_Identity=35.6164383561644, Blast_Score=305, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6324924, Length=487, Percent_Identity=33.264887063655, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321629, Length=496, Percent_Identity=31.25, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6324553, Length=430, Percent_Identity=36.2790697674419, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319824, Length=520, Percent_Identity=30, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322967, Length=515, Percent_Identity=33.0097087378641, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=485, Percent_Identity=29.2783505154639, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324981, Length=526, Percent_Identity=33.6501901140684, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6321053, Length=508, Percent_Identity=29.9212598425197, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320251, Length=531, Percent_Identity=27.1186440677966, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319542, Length=519, Percent_Identity=27.1676300578035, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6319543, Length=483, Percent_Identity=29.399585921325, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319608, Length=512, Percent_Identity=27.34375, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=568, Percent_Identity=26.9366197183099, Blast_Score=189, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55647; Mature: 55516

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQDPNSEHTATASPHLKRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAY
CCCCCCCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHH
LLIGLMVYCLMTSLGEMAAFMPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
AAQLVMGYWFPHVPGVWWSAAFLAVMFLLNALTVRGFGEAEYWFALIKVVTVVAFIGIGL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LMIFGILTGGPTPAWRNFTVGDAPFAGGLPAMMGVAMIAGFSFQGTELIGIAAGESENPH
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
TTIPRAVRQVFWRILLFYVLAIFVIGMLVPYTDPSLLKSDVTDVGVSPFALVFRHAGLAF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
AAGVMNAVILTAVLSAGNSGMYASTRMLYDLAREGRAPRVFARLSKGGVPRNALIATTAV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
GALCFLSSRFGDKTVYLWLLNTSGMTGFIAWLGIAVSHYRFRRGFVKQGFALSRLPYRSR
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHC
LFPYGPIFAFVLCLVIALGQDYQAFLSNRIDWVGVLATYIGIPLFLVVWLGYRVTHRGSR
CCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LVRYEDMEIAPWLDDDTRREARQIKQQAETA
EEEEECCEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLQDPNSEHTATASPHLKRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAY
CCCCCCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHH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EEEEECCEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]